Abstract:
:To find the possible association of gene methylation of p16(INK4a) and O(6)-Methylguanine-DNA Methyltransferase (O(6)-MGMT) with occupational exposure to radon, 91 male miners from a uranium mine in China were divided into 4 groups according to the cumulative doses of radon exposure from 2 to 425 WLM (working-level months), and aberrant promoter methylation of p16(INK4a) and O(6)-MGMT genes in sputum samples was determined by a specific PCR assay. The results revealed that the methylated rates of 16(INK4a) gene (z=2.844, P=0.005) and O(6)-MGMT gene (z=3.034, P=0.002), and the total methylated rate of these two genes (z=3.859, P=0.0001) increased significantly with the cumulative doses of radon among the miners. This methylation could be applied as a potential marker for the detection of early DNA damage induced by occupational radon exposure.
journal_name
J Occup Healthjournal_title
Journal of occupational healthauthors
Su S,Jin Y,Zhang W,Yang L,Shen Y,Cao Y,Tong Jdoi
10.1539/joh.48.261subject
Has Abstractpub_date
2006-07-01 00:00:00pages
261-6issue
4eissn
1341-9145issn
1348-9585pii
JST.JSTAGE/joh/48.261journal_volume
48pub_type
杂志文章abstract:OBJECTIVE:Working long hours is a potential health hazard. Although self-reporting of working hours in various time frames has been used in epidemiologic studies, its validity is unclear. The objective of this study was to examine the validity and reproducibility of self-reported working hours among Japanese male emplo...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.15-0260-OA
更新日期:2016-07-22 00:00:00
abstract:OBJECTIVES:Inhalation toxicities of indium-tin oxide (ITO) and indium oxide (IO) in mice were characterized in comparison with those previously reported in rats. METHODS:B6C3F(1) mice of both sexes were exposed by inhalation to ITO or IO aerosol for 6 h/day, 5 day/wk for 2 wk at 0, 0.1, 1, 10 or 100 mg/m(3) or 13 wk a...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.10-0053-br
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVES:Arsine, a potent hemolytic agent, is widely used in the semiconductor industry. We report a case of arsine poisoning confirmed by arsenic speciation analysis in serum and urine that occurred in a recycling factory. CASE:A male worker in his twenties noticed hematuria 3 h after finishing work and was admitte...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.l10108
更新日期:2011-01-01 00:00:00
abstract::Workplace violence, a possible cause of job stress, has recently become an important concern in occupational health. This study determined the prevalence of workplace violence and its risk factors for employees at a psychiatric hospital in Taiwan. A questionnaire developed by ILO/ICN/WHO/PSI was first translated and v...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.l7132
更新日期:2008-01-01 00:00:00
abstract::This study assessed the relationship of age, poor perception of working condition, poor safety environment, poor management and supervision, risk-taking behavior, emotional instability, negative job involvement, job dissatisfaction, job stress, and poor safety performance of workers to occupational injuries. This case...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.46.470
更新日期:2004-11-01 00:00:00
abstract::This paper examines the effects of shift work on the lifestyles of female factory workers. As an indicator of healthy lifestyle habits, we used a scoring system (referred to below as the 'health score') based on Lester Breslow's health habits. The 'health score' of the women was higher than that of the men, but the sh...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.46.192
更新日期:2004-05-01 00:00:00
abstract::Although the main hazard in cement processing is dust and respiratory tract disorders are the most important group of occupational diseases in this industry, evidence for associations between exposure to cement dust and either respiratory symptoms or functional impairment has not been conclusive. This study was, there...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.49.273
更新日期:2007-07-01 00:00:00
abstract:OBJECTIVES:Although many studies have examined locomotive syndrome (LS) among elderly people, few studies have examined LS in young- and middle-aged adults. This study aimed to provide basic data on the epidemiological characteristics of LS, including in young- and middle-aged adults. METHOD:We conducted a cross-secti...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1002/1348-9585.12053
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVES:This study aimed to investigate the association between occupational clusters and allergic rhinitis (AR). METHODS:The study was based on data from the Korean National Health and Nutrition Examination Survey (KNHANES: 2007-2015). This study included 46,965 individuals: 20,491 men and 26,474 women. AR was def...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.2017-0234-OA
更新日期:2018-07-25 00:00:00
abstract::This Document, "Guidelines for personal exposure monitoring of chemicals" ("this Guideline"), has been prepared by "The Committee for Personal Exposure Monitoring" ("the Committee") of the Expert Division of Occupational Hygiene & Ergonomics, Japan Society for Occupational Health. Considering the background of the gro...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.17-0311-RA
更新日期:2018-03-27 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate whether sedentary job role and gender are reflected by sedentary risk factors within a university campus. METHODS:Following institutional ethical approval, 80 U.K. university campus employees were recruited, and 34 of them (age 47.8 ± 11.9 years, height 169 ± 1.0 cm,...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.12-0158-oa
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVES:Many kinds of heavy metals are used in industry; thus, it is important for us to clarify their toxicity. For example, lead, which is a component of solder, is notorious for its neurotoxicity, and substitute materials have been sought for many years. Therefore, we examined the genotoxicity of lead and also th...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.l9080
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVES:The aim of this review was to summarize the lessons learned from the experience in protecting the health of workers engaged in operations following the accident at the Fukushima Daiichi Nuclear Power Plant (NPP). METHODS:We reviewed all types of scientific papers examining workers' health found in Medline a...
journal_title:Journal of occupational health
pub_type: 杂志文章,评审
doi:10.1539/joh.15-0084-RA
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:Titanium dioxide nanoparticles are widely used as UV filters in cosmetics and as a photocatalyst. We evaluated pulmonary responses to different crystal forms of TiO2 nanoparticles. METHODS:We used 4 different TiO2 samples with similar specific surface areas (anatase, rutile, amorphous, and P25). Each sample ...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.16-0094-OA
更新日期:2016-11-29 00:00:00
abstract:OBJECTIVE:The differences in the methodologies of various occupational health risk assessment (OHRA) models have not been extensively reported. We aimed to understand the qualitative and quantitative differences between common OHRA models in typical industries. METHODS:The Environmental Protection Agency (EPA), Austra...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.2018-0039-OA
更新日期:2018-09-26 00:00:00
abstract::With the immense economic growth and social development, China has gained worldwide attention. With the quick growth of industrialization, several international professionals are gaining interest in occupational management system and in the role of the Chinese Government in protecting the worker's health. The Law on P...
journal_title:Journal of occupational health
pub_type: 杂志文章,评审
doi:10.1539/joh.17-0229-RA
更新日期:2018-03-27 00:00:00
abstract:OBJECTIVES:The present study examined how job demands affect an intimate partner's well-being. We hypothesized that job demands have a negative influence on partner well-being through the experience of work-family conflict (WFC) and an impaired quality of the relationship (reduced social support and increased social un...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.l8160
更新日期:2009-01-01 00:00:00
abstract::Sleep Apnea Syndrome (SAS) is a condition characterized by sleep-disordered breathing resulting in health impairment and sleep problems. From the viewpoints of the prevention of health impairment, accidents at work and traffic accidents, active implementation of screening for SAS in workplaces is necessary. Using a po...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.49.1
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate the association between skill underutilization, a psychological job stressor proposed in the NIOSH (National Institute for Occupational Safety and Health) job stress model, and the prevalence of hypertension. METHODS:We studied sitting blood pressure and fasting bloo...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.13-0146-br
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVES:Spinal pain is a significant occupational health issue. Whilst neck pain and low back pain have received considerable attention, thoracic spinal pain (TSP) has not. The objective of this study was to systematically identify and report the evidence describing the prevalence and correlates of TSP within occupa...
journal_title:Journal of occupational health
pub_type: 杂志文章,评审
doi:10.1539/joh.k8007
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to develop and validate a simple and reliable gas chromatography-mass spectrometry (GC-MS) method to simultaneously determine urinary 1-naphthol (1-NAP) and 2-naphthol (2-NAP) for biological monitoring of occupational exposure to naphthalene. METHODS:NAPs were derivatized in situ w...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1002/1348-9585.12144
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:This report reviews the carcinogenicity of multi-walled carbon nanotubes (MWCNTs) in experimental animals, concentrating on MWNT-7, a straight fibrous MWCNT. METHODS:MWCNTs were administered to mice and rats by intraperitoneal injection, intrascrotal injection, subcutaneous injection, intratracheal instilla...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.17-0102-RA
更新日期:2018-01-25 00:00:00
abstract::This study prospectively examined the association between perceived noise exposure at work and cerebrovascular diseases among Japanese male workers. A baseline survey was conducted between 1988 and 1990, which involved 110,792 inhabitants (age range: 40-79 yr) from 45 areas throughout Japan. Subsequent causes of death...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.49.382
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVES:Along with technological innovations for improving the efficiency of printing, nanoparticles have been added to the surface of toners, and there is concern about the harmful effects of those components. We investigated, through a long-term observation following intratracheal instillation using rats, whether ...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1002/1348-9585.12146
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to investigate the effects of Nickel (Ni) -smelting fumes on oncogenic proteins in vivo and in vitro. METHODS:Ni fallout beside a Ni smelting furnace in a factory was sampled to study its toxic effect. The effects of Ni-smelting fumes on the regulation of PI3K and ERK signaling ...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.15-0287-OA
更新日期:2016-09-30 00:00:00
abstract:BACKGROUND:Nurses are one of the population groups with the highest prevalence of musculoskeletal disorders (MSDs). At many sites, musculoskeletal symptoms (MS) represent a major health-care burden, adversely affecting nurses' quality of life and giving rise to mental health issues. OBJECTIVES:This study measured the ...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1002/1348-9585.12161
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:Work-related psychosocial hazards are associated with adverse health outcomes among workers. The association between psychosocial hazards and physiological health outcomes among laboratory technicians has not been studied previously. The objective of this study was to measure the association between work-rel...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.13-0050-fs
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVES:Among the many chemicals used in a hair salon, exposure to thioglycolic acid (TGA) used for permanent waving solutions (PWS) potentially causes adverse health effects. However, no report has been previously published on the indoor air concentrations of TGA in a beauty salon that contributes to assessment of ...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.12-0084-fs
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVES:Independent exposure to noise or organic solvents is reported to be associated with cardiovascular effects, but the effect of joint exposure is unclear. The present study aimed to investigate effects of noise, a mixture of organic solvents (N,N-dimethylformamide (DMF) and toluene) and their interaction on hy...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.l8121
更新日期:2009-01-01 00:00:00
abstract::This cross-sectional study on a random sample of 1,500 ambulance personnel investigated the relationships between self-reported work-related physical and psychosocial factors, worry about work conditions, and musculoskeletal disorders among female and male ambulance personnel. Three different outcomes, complaints, act...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.47.481
更新日期:2005-11-01 00:00:00