Aberrant promoter methylation of p16(INK4a) and O(6)-methylguanine-DNA methyltransferase genes in workers at a Chinese uranium mine.

Abstract:

:To find the possible association of gene methylation of p16(INK4a) and O(6)-Methylguanine-DNA Methyltransferase (O(6)-MGMT) with occupational exposure to radon, 91 male miners from a uranium mine in China were divided into 4 groups according to the cumulative doses of radon exposure from 2 to 425 WLM (working-level months), and aberrant promoter methylation of p16(INK4a) and O(6)-MGMT genes in sputum samples was determined by a specific PCR assay. The results revealed that the methylated rates of 16(INK4a) gene (z=2.844, P=0.005) and O(6)-MGMT gene (z=3.034, P=0.002), and the total methylated rate of these two genes (z=3.859, P=0.0001) increased significantly with the cumulative doses of radon among the miners. This methylation could be applied as a potential marker for the detection of early DNA damage induced by occupational radon exposure.

journal_name

J Occup Health

authors

Su S,Jin Y,Zhang W,Yang L,Shen Y,Cao Y,Tong J

doi

10.1539/joh.48.261

subject

Has Abstract

pub_date

2006-07-01 00:00:00

pages

261-6

issue

4

eissn

1341-9145

issn

1348-9585

pii

JST.JSTAGE/joh/48.261

journal_volume

48

pub_type

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