Abstract:
:To find the possible association of gene methylation of p16(INK4a) and O(6)-Methylguanine-DNA Methyltransferase (O(6)-MGMT) with occupational exposure to radon, 91 male miners from a uranium mine in China were divided into 4 groups according to the cumulative doses of radon exposure from 2 to 425 WLM (working-level months), and aberrant promoter methylation of p16(INK4a) and O(6)-MGMT genes in sputum samples was determined by a specific PCR assay. The results revealed that the methylated rates of 16(INK4a) gene (z=2.844, P=0.005) and O(6)-MGMT gene (z=3.034, P=0.002), and the total methylated rate of these two genes (z=3.859, P=0.0001) increased significantly with the cumulative doses of radon among the miners. This methylation could be applied as a potential marker for the detection of early DNA damage induced by occupational radon exposure.
journal_name
J Occup Healthjournal_title
Journal of occupational healthauthors
Su S,Jin Y,Zhang W,Yang L,Shen Y,Cao Y,Tong Jdoi
10.1539/joh.48.261subject
Has Abstractpub_date
2006-07-01 00:00:00pages
261-6issue
4eissn
1341-9145issn
1348-9585pii
JST.JSTAGE/joh/48.261journal_volume
48pub_type
杂志文章abstract:OBJECTIVES:Dental caries and periodontal disease are highly prevalent in the Japanese adult population. Oral examination is an effective method to find various oral health problems in their early stages. However, workplace oral examination is not common in Japan. The purpose of this study was to examine the relationshi...
journal_title:Journal of occupational health
pub_type: 杂志文章
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更新日期:2011-01-01 00:00:00
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更新日期:2020-01-01 00:00:00
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journal_title:Journal of occupational health
pub_type: 杂志文章
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更新日期:2006-03-01 00:00:00
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journal_title:Journal of occupational health
pub_type: 杂志文章
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更新日期:2009-01-01 00:00:00
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journal_title:Journal of occupational health
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doi:10.1539/joh.17-0150-CS
更新日期:2018-03-27 00:00:00
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journal_title:Journal of occupational health
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更新日期:2020-01-01 00:00:00
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更新日期:2010-01-01 00:00:00
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journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.l8043
更新日期:2008-01-01 00:00:00
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doi:10.1539/joh.l7072
更新日期:2008-01-01 00:00:00
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更新日期:2003-07-01 00:00:00
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journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.11-0111-oa
更新日期:2011-01-01 00:00:00
abstract::Infrared Spectrophotometry (IR) is now widely used to determine crystalline silica in industrial dust samples. Though the IR method has many advantages when dealing with respirable dust samples, some serious analytical errors are often caused by interference minerals contamination. These minerals have a characteristic...
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更新日期:2003-03-01 00:00:00
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journal_title:Journal of occupational health
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更新日期:2016-11-29 00:00:00
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journal_title:Journal of occupational health
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doi:10.1539/joh.15-0253-FS
更新日期:2017-01-24 00:00:00
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journal_title:Journal of occupational health
pub_type: 杂志文章,评审
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更新日期:2005-01-01 00:00:00
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更新日期:2008-01-01 00:00:00
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journal_title:Journal of occupational health
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doi:10.1539/joh.14-0077-OA
更新日期:2014-01-01 00:00:00
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journal_title:Journal of occupational health
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doi:10.1002/1348-9585.12144
更新日期:2020-01-01 00:00:00
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journal_title:Journal of occupational health
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更新日期:2018-07-25 00:00:00
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更新日期:2007-01-01 00:00:00
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更新日期:2012-01-01 00:00:00
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更新日期:2009-01-01 00:00:00
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更新日期:2010-01-01 00:00:00
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更新日期:2009-01-01 00:00:00
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更新日期:2007-07-01 00:00:00
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更新日期:2009-01-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2006-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2020-01-01 00:00:00
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journal_title:Journal of occupational health
pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
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更新日期:2015-01-01 00:00:00