Abstract:
OBJECTIVE:Titanium dioxide nanoparticles are widely used as UV filters in cosmetics and as a photocatalyst. We evaluated pulmonary responses to different crystal forms of TiO2 nanoparticles. METHODS:We used 4 different TiO2 samples with similar specific surface areas (anatase, rutile, amorphous, and P25). Each sample was suspended in distilled water and intratracheally instilled to male Wister rats at the dose of 1 mg per rat. Five rats per group were sacrificed at 3 days, 1 month, and 6 months after instillation, and bronchoalveolar lavage fluid was collected from the right lung to determine the total cell count and polymorphonuclear cell (PMN) counts. The left lung tissues were stained with hematoxylin and eosin for the evaluation of inflammation and with elastica van Gieson for the evaluation of collagen deposition. RESULTS:The total cell counts and PMN counts of the amorphous and P25 of four samples showed a significant increase compared with the control group at 3 days after instillation. The inflammation rate of P25 also showed a significant increase compared with controls at 3 days. The collagen deposition rate in the alveolar duct of P25 increased significantly compared with controls from 3 days to 6 months. The other samples showed a mild response after instillation. CONCLUSION:Although the TiO2 nanoparticles used in this study had similar specific surface areas, there were different inflammatory responses in the rat lungs. Other factors, such as different production processes or the surface activities of particles, may have been responsible for the different responses.
journal_name
J Occup Healthjournal_title
Journal of occupational healthauthors
Okada T,Ogami A,Lee BW,Kadoya C,Oyabu T,Myojo Tdoi
10.1539/joh.16-0094-OAsubject
Has Abstractpub_date
2016-11-29 00:00:00pages
602-611issue
6eissn
1341-9145issn
1348-9585journal_volume
58pub_type
杂志文章abstract:OBJECTIVES:The main objectives of this cross-sectional descriptive study were to identify the prevalence of musculoskeletal symptoms and workstation biomechanical risk levels for garment workers in Kandal Province, Cambodia. METHODS:This cross-sectional descriptive study used multistage sampling techniques to select 7...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.15-0100-FS
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To investigate the association between dental consultation and oral health status among male Japanese employees. METHODS:The participants were 3351 male employees who received a workplace oral health examination conducted at the ages of 35, 40, 45, 50, 55, and 59 years before retirement in conjunction with a...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1002/1348-9585.12104
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:Polychlorinated biphenyls (PCBs) are considered probable human carcinogens by the International Agency for Research on Cancer and one congener, PCB126, has been rated as a known human carcinogen. A period-specific job exposure matrix (JEM) was developed for former PCB-exposed capacitor manufacturing workers ...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.l9151
更新日期:2010-01-01 00:00:00
abstract::To find the possible association of gene methylation of p16(INK4a) and O(6)-Methylguanine-DNA Methyltransferase (O(6)-MGMT) with occupational exposure to radon, 91 male miners from a uranium mine in China were divided into 4 groups according to the cumulative doses of radon exposure from 2 to 425 WLM (working-level mo...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.48.261
更新日期:2006-07-01 00:00:00
abstract:OBJECTIVES:The aims of this study were to examine sexual harassment (SH) among hospital staffs in Taiwan, in terms of three-month incidence rate, the frequency of each type and the perception of SH, perpetrated by coworkers, patients and patients' families and to investigate the gender differences for these issues. ME...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.11-0063-fs
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVES:The sum of urinary inorganic arsenic (iAs), monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA) concentrations is used for the biological monitoring of occupational iAs exposure. Although DMA is a major metabolite of iAs, it is an inadequate index because high DMA levels are present in urine after s...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.15-0241-OA
更新日期:2016-05-25 00:00:00
abstract:OBJECTIVES:Despite the great impact the migration has had in economic, social and health-related fields, and the repercussions of alcohol consumption on them, few data exist concerning the extent of alcohol consumption in migrant workers. The aims of this study were to identify workers with a hazardous drinking problem...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.13-0119-oa
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:Nickel oxide nanoparticles (NiONPs) are representative metal oxide NPs and are categorized as an insoluble nickel compound. Our previous studies suggested that NiONPs have more pulmonary toxicity than micron-sized NiO because they may dissolve slowly and produce many more Ni ions. We confirmed the hypothesis ...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1002/1348-9585.12162
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Petrochemical industries are known as sources of many toxic chemicals. Safety and health risks of the petrochemical workers employed at Map Ta Phut Industrial Estate, located in Rayong, Thailand, are potentially high. METHODS:The research materials consisted of documents emanating from statutory reports on ...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.11-0091-oa
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to examine the effects of noise exposure on spatial learning and memory and associated mechanisms in the hippocampus (HIP). METHODS:Forty-eight male SD rats were grouped as: A, control; B, Morris water maze (MWM) training group; C, noise exposure group; and D, noise exposure fo...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.l8084
更新日期:2009-01-01 00:00:00
abstract::This study was aimed at understanding the relationship among menstrual pattern, dysmenorrhea, life style and working conditions in nurses. The nurses were randomly selected from a medical center in Northern Taiwan. Each subject completed daily records including life and working conditions during the study period. The ...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.47.149
更新日期:2005-03-01 00:00:00
abstract:OBJECTIVES:Arsine, a potent hemolytic agent, is widely used in the semiconductor industry. We report a case of arsine poisoning confirmed by arsenic speciation analysis in serum and urine that occurred in a recycling factory. CASE:A male worker in his twenties noticed hematuria 3 h after finishing work and was admitte...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.l10108
更新日期:2011-01-01 00:00:00
abstract::The purpose of this study was to assess the value and usefulness of high resolution computed tomography (HRCT) in the diagnostics of small opacities and complications of silicosis in mine machinery manufacturing workers, compared to conventional radiograms. The diagnosis of silicosis is mainly based on the radiologica...
journal_title:Journal of occupational health
pub_type: 杂志文章,随机对照试验
doi:10.1539/joh.l8015
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVES:For occupational health (OH) nurses to perform activities effectively, not only skills and knowledge but also competencies proposed by Dr. McClelland are indispensable. This study aimed to identify competencies required for OH nurses and to show their structure diagram. METHODS:Qualitative descriptive resea...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.16-0188-OA
更新日期:2017-11-25 00:00:00
abstract:OBJECTIVES:The present study examined how job demands affect an intimate partner's well-being. We hypothesized that job demands have a negative influence on partner well-being through the experience of work-family conflict (WFC) and an impaired quality of the relationship (reduced social support and increased social un...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.l8160
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVES:Presenteeism is undoubtedly a widespread phenomenon in organizations. Research on presenteeism has been conducted for decades in the broader workforce (eg, nurses, doctors, teachers, police officers). Occupational stress and turnover intention in occupational therapy have been extensively studied. However, t...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1002/1348-9585.12153
更新日期:2020-01-01 00:00:00
abstract::This study presents the results of an investigation of respiratory symptoms, pulmonary function and chest X-ray examinations, and analysis of antibodies to fungi of 197 tussah silk-processing workers and 40 control workers. An industrial hygiene survey and environmental mycological studies were also conducted. The dus...
journal_title:Journal of occupational health
pub_type: 临床试验,杂志文章
doi:10.1539/joh.46.418
更新日期:2004-09-01 00:00:00
abstract::The relationships between alcohol consumption, serum gamma-glutamyltransferase (GGT) levels, and the prevalence of major coronary risk factors were analyzed cross-sectionally in 2,399 male and 1,402 female middle-aged workers, to clarify the effects of moderate alcohol consumption on the development of the metabolic s...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.45.293
更新日期:2003-09-01 00:00:00
abstract:OBJECTIVES:This field study aimed to determine the incidence and distribution of needlestick injuries among medical trainees at a community teaching hospital in Toronto, Canada. METHODS:The study was performed during the 2013-2015 academic years at Toronto East General Hospital (TEGH), a University of Toronto-affiliat...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.15-0253-FS
更新日期:2017-01-24 00:00:00
abstract:OBJECTIVES:Dental caries and periodontal disease are highly prevalent in the Japanese adult population. Oral examination is an effective method to find various oral health problems in their early stages. However, workplace oral examination is not common in Japan. The purpose of this study was to examine the relationshi...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.o10031
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVES:This study investigated potential associations between having a person in need of nursing care at home and psychological distress amongst the Japanese working population, using a nationally representative sample. METHODS:We extracted data from the 2013 Comprehensive Survey of Living Conditions conducted by ...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.2017-0295-OA
更新日期:2018-11-27 00:00:00
abstract:OBJECTIVE:The purpose of this study was to investigate the effects of Nickel (Ni) -smelting fumes on oncogenic proteins in vivo and in vitro. METHODS:Ni fallout beside a Ni smelting furnace in a factory was sampled to study its toxic effect. The effects of Ni-smelting fumes on the regulation of PI3K and ERK signaling ...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.15-0287-OA
更新日期:2016-09-30 00:00:00
abstract:OBJECTIVES:The aim of this study was to evaluate two-point discrimination (2PD) sense and kinesthetic sense dysfunctions in carpal tunnel syndrome (CTS) patients compared with a healthy group. METHODS:The 2PD sense, muscle force, and kinesthetic differentiation (KD) of strength; the range of motion in radiocarpal arti...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.15-0108-OA
更新日期:2016-06-16 00:00:00
abstract:OBJECTIVES:In this study, we focused on the qualitative and quantitative differences of the lung lesions induced by single or multiple intratracheal administration of nickel oxide nanoparticles (NiO). METHODS:Male rats were randomized into groups receiving intratracheal administrations in a single dose or two to four ...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.16-0184-OA
更新日期:2017-03-28 00:00:00
abstract:OBJECTIVE:The differences in the methodologies of various occupational health risk assessment (OHRA) models have not been extensively reported. We aimed to understand the qualitative and quantitative differences between common OHRA models in typical industries. METHODS:The Environmental Protection Agency (EPA), Austra...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.2018-0039-OA
更新日期:2018-09-26 00:00:00
abstract:OBJECTIVES:Independent exposure to noise or organic solvents is reported to be associated with cardiovascular effects, but the effect of joint exposure is unclear. The present study aimed to investigate effects of noise, a mixture of organic solvents (N,N-dimethylformamide (DMF) and toluene) and their interaction on hy...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.l8121
更新日期:2009-01-01 00:00:00
abstract:PURPOSE:The aim of this study was to estimate the prevalence of dry eye disease (DED) in Japanese visual display terminal (VDT) workers and identify simple methods for screening DED during occupational health examinations. METHODS:This study involved 369 (331 men and 38 women; mean age, 44.4 [8.8] years) workers engag...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.14-0243-OA
更新日期:2015-01-01 00:00:00
abstract::Thioglycolic acid (TGA) is the active ingredient of permanent-waving solution (PWS). TGA has been shown to be a chemical of high toxicity, which can be absorbed through intact skin and cause damage to organs or systems in animals. This study evaluated the effect of TGA-containing PWS on the health of a human populatio...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.45.400
更新日期:2003-11-01 00:00:00
abstract::The effort-reward imbalance is an important psychosocial factor which is related to poor health among employees. However, there are few studies that have evaluated effort-reward imbalance among medical residents. The present study was done to determine the association between psychosocial factors at work as defined by...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.l8043
更新日期:2008-01-01 00:00:00
abstract::Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) are synthetic surfactants used in Japan. An epidemiological study of workers exposed to PFOA revealed a significant increase in prostate cancer mortality. A cross-sectional study of PFOA-exposed workers showed that PFOA perturbs sex hormone homeostasis. We...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.46.49
更新日期:2004-01-01 00:00:00