Abstract:
OBJECTIVE:The purpose of this study was to investigate the effects of Nickel (Ni) -smelting fumes on oncogenic proteins in vivo and in vitro. METHODS:Ni fallout beside a Ni smelting furnace in a factory was sampled to study its toxic effect. The effects of Ni-smelting fumes on the regulation of PI3K and ERK signaling pathways and the important downstream hypoxia inducible factor, HIF-1α, were studied both in NIH/3T3 cells and in the lung tissue of rats. NIH/3T3 cell transformation induced by Ni-smelting fumes was also observed. RESULTS:Ni-smelting fumes activated PI3K, p-AKT, p70S6K1, and ERK proteins and increased HIF-1α expression in a time- and dose-dependent manner. However, activation was suppressed when NIH/3T3 cells were pretreated with PI3K/AKT or ERK inhibitors. Ni-smelting fumes caused malignant transformation of NIH/3T3 cells. CONCLUSIONS:Ni-smelting fumes increased the expression of HIF-1α through the PI3K/ERK pathway in NIH/3T3 cells and induced malignant transformation in these cells indicating that Ni-smelting fumes may be a potential carcinogen in mammalian cells.
journal_name
J Occup Healthjournal_title
Journal of occupational healthauthors
Han D,Yang Y,Zhang L,Wang C,Wang Y,Tan WQ,Hu XY,Wu YHdoi
10.1539/joh.15-0287-OAsubject
Has Abstractpub_date
2016-09-30 00:00:00pages
413-424issue
5eissn
1341-9145issn
1348-9585journal_volume
58pub_type
杂志文章abstract::Cadmium fluoride (CdF2, CdF for short) is the most lethal and hepatotoxic of all Cd-containing compounds. The toxic effects of CdF appear to depend on its detoxification and elimination. This study was designed to determine the early dynamics of the absorption, systemic distribution, and metabolism of CdF. The kinetic...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.l8016
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVES:The currently used predictive equations of lung function in North China were derived from early study and have not been updated for nearly two decades. METHODS:Using American Thoracic Society (ATS) standards, sex-specific spirometric predictive equations for forced vital capacity (FVC), forced expiratory vo...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.l9006
更新日期:2009-01-01 00:00:00
abstract::This study assessed the relationship of age, poor perception of working condition, poor safety environment, poor management and supervision, risk-taking behavior, emotional instability, negative job involvement, job dissatisfaction, job stress, and poor safety performance of workers to occupational injuries. This case...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.46.470
更新日期:2004-11-01 00:00:00
abstract::The concept of biological monitoring (BM) has gained the special interest of individual scientists and international organizations. Today, when analytical problems have almost ceased due to new laboratory techniques and quality assurance systems, the methods for interpretation of results have become the most important...
journal_title:Journal of occupational health
pub_type: 杂志文章,评审
doi:10.1539/joh.47.22
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVE:This study aimed to evaluate the efficacy of increased daily walking steps on the 6-month incidence of neck pain among office workers. METHODS:Healthy office workers with high risk of neck pain were recruited into a 6-month prospective cluster-randomized controlled trial. Participants were randomly assigned ...
journal_title:Journal of occupational health
pub_type: 杂志文章,随机对照试验
doi:10.1002/1348-9585.12106
更新日期:2020-01-01 00:00:00
abstract::This study prospectively examined the association between perceived noise exposure at work and cerebrovascular diseases among Japanese male workers. A baseline survey was conducted between 1988 and 1990, which involved 110,792 inhabitants (age range: 40-79 yr) from 45 areas throughout Japan. Subsequent causes of death...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.49.382
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVES:There are high levels of global and national underemployment, but limited information is available on the impact of this phenomenon on the quality of employees' working lives. This study examines the relations among perceived employer support for creative work, different forms of underemployment and employee...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.12-0192-oa
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVES:Long working hours may impact human health. In Japan, teachers tend to work long hours. From 2002 to 2012, the number of leaves of absence due to diseases other than mental disorders, or mental disorders among public school teachers increased by 1.3 times (from 2,616 to 3,381), or 1.8 times (from 2,687 to 4,...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.15-0053-OA
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVES:For occupational health (OH) nurses to perform activities effectively, not only skills and knowledge but also competencies proposed by Dr. McClelland are indispensable. This study aimed to identify competencies required for OH nurses and to show their structure diagram. METHODS:Qualitative descriptive resea...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.16-0188-OA
更新日期:2017-11-25 00:00:00
abstract:BACKGROUNDS:Two-component acrylic resin used in nail art and dentistry can cause allergic contact dermatitis (ACD), but only a few reports from Japan have been published. CASES:A 35-year-old female manicurist (case 1) and 30-year-old female dental hygienist (case 2) were diagnosed with ACD caused by ethyl methacrylate...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.13-0244-cs
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:To investigate associations of work-related stressors and their changes over time with the risk of developing metabolic syndrome (MetS) among Japanese manufacturing workers. METHODS:Participants were 1,040 employees aged 19 to 68 years who were free from MetS at baseline and completed the three year-interval...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.2017-0298-OA
更新日期:2018-11-27 00:00:00
abstract:PURPOSE:The aim of this study was to estimate the prevalence of dry eye disease (DED) in Japanese visual display terminal (VDT) workers and identify simple methods for screening DED during occupational health examinations. METHODS:This study involved 369 (331 men and 38 women; mean age, 44.4 [8.8] years) workers engag...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.14-0243-OA
更新日期:2015-01-01 00:00:00
abstract::This study was aimed at understanding the relationship among menstrual pattern, dysmenorrhea, life style and working conditions in nurses. The nurses were randomly selected from a medical center in Northern Taiwan. Each subject completed daily records including life and working conditions during the study period. The ...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.47.149
更新日期:2005-03-01 00:00:00
abstract:OBJECTIVES:Arsine, a potent hemolytic agent, is widely used in the semiconductor industry. We report a case of arsine poisoning confirmed by arsenic speciation analysis in serum and urine that occurred in a recycling factory. CASE:A male worker in his twenties noticed hematuria 3 h after finishing work and was admitte...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.l10108
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVES:The sum of urinary inorganic arsenic (iAs), monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA) concentrations is used for the biological monitoring of occupational iAs exposure. Although DMA is a major metabolite of iAs, it is an inadequate index because high DMA levels are present in urine after s...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.15-0241-OA
更新日期:2016-05-25 00:00:00
abstract::The aim was to explore long-term changes in the perception of job characteristics--based on the Job Content Questionnaire (JCQ)--in view of the changing labor market in Western societies. A total number of 2,821 workers from nine companies were involved in the longitudinal Belstress-project. Data were gathered on two ...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.48.339
更新日期:2006-09-01 00:00:00
abstract:OBJECTIVES:Independent exposure to noise or organic solvents is reported to be associated with cardiovascular effects, but the effect of joint exposure is unclear. The present study aimed to investigate effects of noise, a mixture of organic solvents (N,N-dimethylformamide (DMF) and toluene) and their interaction on hy...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.l8121
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:Titanium dioxide nanoparticles are widely used as UV filters in cosmetics and as a photocatalyst. We evaluated pulmonary responses to different crystal forms of TiO2 nanoparticles. METHODS:We used 4 different TiO2 samples with similar specific surface areas (anatase, rutile, amorphous, and P25). Each sample ...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.16-0094-OA
更新日期:2016-11-29 00:00:00
abstract:OBJECTIVE:Nickel oxide nanoparticles (NiONPs) are representative metal oxide NPs and are categorized as an insoluble nickel compound. Our previous studies suggested that NiONPs have more pulmonary toxicity than micron-sized NiO because they may dissolve slowly and produce many more Ni ions. We confirmed the hypothesis ...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1002/1348-9585.12162
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Nurses are one of the population groups with the highest prevalence of musculoskeletal disorders (MSDs). At many sites, musculoskeletal symptoms (MS) represent a major health-care burden, adversely affecting nurses' quality of life and giving rise to mental health issues. OBJECTIVES:This study measured the ...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1002/1348-9585.12161
更新日期:2020-01-01 00:00:00
abstract::Workplace violence, a possible cause of job stress, has recently become an important concern in occupational health. This study determined the prevalence of workplace violence and its risk factors for employees at a psychiatric hospital in Taiwan. A questionnaire developed by ILO/ICN/WHO/PSI was first translated and v...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.l7132
更新日期:2008-01-01 00:00:00
abstract::Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) are synthetic surfactants used in Japan. An epidemiological study of workers exposed to PFOA revealed a significant increase in prostate cancer mortality. A cross-sectional study of PFOA-exposed workers showed that PFOA perturbs sex hormone homeostasis. We...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.46.49
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVES:Occupational lead (Pb) exposure is still an important health problem in the world. Long-term Pb exposure causes several adverse effects. The aim of this study was to investigate the changes of inflammation markers with chronic Pb exposure by analyzing neopterin levels and kynurenine (Kyn) to tryptophan (Trp)...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.16-0273-OA
更新日期:2017-07-27 00:00:00
abstract:OBJECTIVES:In order to measure occupational exposure concentrations of ethyl tertiary-butyl ether (ETBE), we developed a diffusive sampling method for monitoring ETBE and performed an ETBE exposure assessment. METHODS:The applicability of diffusive samplers was examined by exposing the samplers to ETBE vapor in test c...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.11-0111-oa
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVES:This study aimed to investigate changes in the smoking rate among Korean adults from 1998-2009 by gender and occupational groups. METHODS:Using the data from the first (1998), second (2001), third (2005) and fourth (2009) waves of the Korean National Health and Nutrition Examination Survey (KNHANES), we exa...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.12-0148-oa
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVES:This study aimed to investigate the association between occupational clusters and allergic rhinitis (AR). METHODS:The study was based on data from the Korean National Health and Nutrition Examination Survey (KNHANES: 2007-2015). This study included 46,965 individuals: 20,491 men and 26,474 women. AR was def...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.2017-0234-OA
更新日期:2018-07-25 00:00:00
abstract:OBJECTIVES:Although many studies have examined locomotive syndrome (LS) among elderly people, few studies have examined LS in young- and middle-aged adults. This study aimed to provide basic data on the epidemiological characteristics of LS, including in young- and middle-aged adults. METHOD:We conducted a cross-secti...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1002/1348-9585.12053
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVES:The main objectives of this cross-sectional descriptive study were to identify the prevalence of musculoskeletal symptoms and workstation biomechanical risk levels for garment workers in Kandal Province, Cambodia. METHODS:This cross-sectional descriptive study used multistage sampling techniques to select 7...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.15-0100-FS
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVES:Although well-being at work is important for occupational health, multi-dimensional workplace well-being measures do not exist for Japanese workers. The purpose of this study was to investigate the validity of the Japanese version of the Workplace PERMA-Profiler. METHODS:Japanese workers completed online su...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.2018-0050-OA
更新日期:2018-09-26 00:00:00
abstract::The effects of working hours on health were examined taking psychological job strain into account. White-collar workers employed at the main office of a Japanese manufacturing company provided data for analysis done in 1997. The eligible subjects were 286 workers aged 20-39. Causal relationships between working hours,...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.46.345
更新日期:2004-09-01 00:00:00