Abstract:
OBJECTIVE:The purpose of this study was to investigate the effects of Nickel (Ni) -smelting fumes on oncogenic proteins in vivo and in vitro. METHODS:Ni fallout beside a Ni smelting furnace in a factory was sampled to study its toxic effect. The effects of Ni-smelting fumes on the regulation of PI3K and ERK signaling pathways and the important downstream hypoxia inducible factor, HIF-1α, were studied both in NIH/3T3 cells and in the lung tissue of rats. NIH/3T3 cell transformation induced by Ni-smelting fumes was also observed. RESULTS:Ni-smelting fumes activated PI3K, p-AKT, p70S6K1, and ERK proteins and increased HIF-1α expression in a time- and dose-dependent manner. However, activation was suppressed when NIH/3T3 cells were pretreated with PI3K/AKT or ERK inhibitors. Ni-smelting fumes caused malignant transformation of NIH/3T3 cells. CONCLUSIONS:Ni-smelting fumes increased the expression of HIF-1α through the PI3K/ERK pathway in NIH/3T3 cells and induced malignant transformation in these cells indicating that Ni-smelting fumes may be a potential carcinogen in mammalian cells.
journal_name
J Occup Healthjournal_title
Journal of occupational healthauthors
Han D,Yang Y,Zhang L,Wang C,Wang Y,Tan WQ,Hu XY,Wu YHdoi
10.1539/joh.15-0287-OAsubject
Has Abstractpub_date
2016-09-30 00:00:00pages
413-424issue
5eissn
1341-9145issn
1348-9585journal_volume
58pub_type
杂志文章abstract:OBJECTIVES:There are high levels of global and national underemployment, but limited information is available on the impact of this phenomenon on the quality of employees' working lives. This study examines the relations among perceived employer support for creative work, different forms of underemployment and employee...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.12-0192-oa
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVES:This study aimed to investigate changes in the smoking rate among Korean adults from 1998-2009 by gender and occupational groups. METHODS:Using the data from the first (1998), second (2001), third (2005) and fourth (2009) waves of the Korean National Health and Nutrition Examination Survey (KNHANES), we exa...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.12-0148-oa
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVES:Polychlorinated biphenyls (PCBs) are considered probable human carcinogens by the International Agency for Research on Cancer and one congener, PCB126, has been rated as a known human carcinogen. A period-specific job exposure matrix (JEM) was developed for former PCB-exposed capacitor manufacturing workers ...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.l9151
更新日期:2010-01-01 00:00:00
abstract::Due to the potential for an influenza pandemic, preparedness for infection control in healthcare settings is essential from the standpoint of occupational health for healthcare workers. We conducted questionnaire surveys among Japanese hospitals to assess preparedness at the individual and institutional levels and the...
journal_title:Journal of occupational health
pub_type: 杂志文章,多中心研究
doi:10.1539/joh.50.13
更新日期:2008-01-01 00:00:00
abstract::The aim of this study was to investigate the usefulness of heart rate variability (HRV) and urinary catecholamines (CA) as objective indices of heat stress effect. We examined physiological responses, subjective symptoms, HRV and urinary CA to evaluate the effect of heat exposure on the autonomic nervous system. Six h...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.49.199
更新日期:2007-05-01 00:00:00
abstract:OBJECTIVE:Occupational diseases (OD) are among the most significant issues of work life, with economic, medical, social, and ethical aspects. The majority of studies concerning OD focus on the causes or medical outcomes of OD. There are a limited number of studies investigating the social and economic impacts of being ...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.2017-0282-OA
更新日期:2018-11-27 00:00:00
abstract:OBJECTIVES:The purpose of the present study was to obtain knowledge for improvement of the housing and life among radiation decontamination workers by examining the effect of housing type on anxiety over lack of privacy. METHODS:This cross-sectional study comprised 544 male radiation decontamination workers in Fukushi...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.2018-0007-OA
更新日期:2018-09-26 00:00:00
abstract:OBJECTIVES:Independent exposure to noise or organic solvents is reported to be associated with cardiovascular effects, but the effect of joint exposure is unclear. The present study aimed to investigate effects of noise, a mixture of organic solvents (N,N-dimethylformamide (DMF) and toluene) and their interaction on hy...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.l8121
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVES:Inhalation toxicities of indium-tin oxide (ITO) and indium oxide (IO) in mice were characterized in comparison with those previously reported in rats. METHODS:B6C3F(1) mice of both sexes were exposed by inhalation to ITO or IO aerosol for 6 h/day, 5 day/wk for 2 wk at 0, 0.1, 1, 10 or 100 mg/m(3) or 13 wk a...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.10-0053-br
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVES:Long working hours may impact human health. In Japan, teachers tend to work long hours. From 2002 to 2012, the number of leaves of absence due to diseases other than mental disorders, or mental disorders among public school teachers increased by 1.3 times (from 2,616 to 3,381), or 1.8 times (from 2,687 to 4,...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.15-0053-OA
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:Working long hours is a potential health hazard. Although self-reporting of working hours in various time frames has been used in epidemiologic studies, its validity is unclear. The objective of this study was to examine the validity and reproducibility of self-reported working hours among Japanese male emplo...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.15-0260-OA
更新日期:2016-07-22 00:00:00
abstract:OBJECTIVES:The currently used predictive equations of lung function in North China were derived from early study and have not been updated for nearly two decades. METHODS:Using American Thoracic Society (ATS) standards, sex-specific spirometric predictive equations for forced vital capacity (FVC), forced expiratory vo...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.l9006
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVES:In this study, we focused on the qualitative and quantitative differences of the lung lesions induced by single or multiple intratracheal administration of nickel oxide nanoparticles (NiO). METHODS:Male rats were randomized into groups receiving intratracheal administrations in a single dose or two to four ...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.16-0184-OA
更新日期:2017-03-28 00:00:00
abstract::The aim was to explore long-term changes in the perception of job characteristics--based on the Job Content Questionnaire (JCQ)--in view of the changing labor market in Western societies. A total number of 2,821 workers from nine companies were involved in the longitudinal Belstress-project. Data were gathered on two ...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.48.339
更新日期:2006-09-01 00:00:00
abstract:OBJECTIVES:This study investigated potential associations between having a person in need of nursing care at home and psychological distress amongst the Japanese working population, using a nationally representative sample. METHODS:We extracted data from the 2013 Comprehensive Survey of Living Conditions conducted by ...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.2017-0295-OA
更新日期:2018-11-27 00:00:00
abstract::Objective of this study is to clarify the health-related conditions of Japanese male expatriates in Thailand. Records of Japanese male expatriates in their 30s to 50s who consulted outpatient clinics at Bangkok Hospital in 2005 were analyzed for number and type of outpatient visits then compared with data from the "Pa...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.l7072
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to determine ultraviolet (UV) action spectra for cell killing of primary porcine lens epithelial cells (LECs) that can be used to establish guidelines for evaluation of the hazard of cataract due to UV exposure in the workplace. METHODS:Primary porcine LECs were exposed to differen...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.11-0215-oa
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVES:For occupational health (OH) nurses to perform activities effectively, not only skills and knowledge but also competencies proposed by Dr. McClelland are indispensable. This study aimed to identify competencies required for OH nurses and to show their structure diagram. METHODS:Qualitative descriptive resea...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.16-0188-OA
更新日期:2017-11-25 00:00:00
abstract:OBJECTIVES:Work-related psychosocial hazards are associated with adverse health outcomes among workers. The association between psychosocial hazards and physiological health outcomes among laboratory technicians has not been studied previously. The objective of this study was to measure the association between work-rel...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.13-0050-fs
更新日期:2014-01-01 00:00:00
abstract::Workplace violence, a possible cause of job stress, has recently become an important concern in occupational health. This study determined the prevalence of workplace violence and its risk factors for employees at a psychiatric hospital in Taiwan. A questionnaire developed by ILO/ICN/WHO/PSI was first translated and v...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.l7132
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVES:Presenteeism is undoubtedly a widespread phenomenon in organizations. Research on presenteeism has been conducted for decades in the broader workforce (eg, nurses, doctors, teachers, police officers). Occupational stress and turnover intention in occupational therapy have been extensively studied. However, t...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1002/1348-9585.12153
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:There is concern that sound via earphones and headphones attached to headsets used in workplaces may be a risk factor for noise-induced hearing loss (NIHL). Although there are some previous studies investigating exposure to noise from headphones, almost none have assessed the risks to workers who use earphon...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.13-0285-oa
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVES:The aims of the study were to investigate the systematic classification of subsidiary behaviors during visual display terminal (VDT) work and discuss the interpretation of these behaviors through an interactive model of subsidiary behaviors, work performance and autonomic nerve activity. METHODS:Twelve univ...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.l9110
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Nurses are one of the population groups with the highest prevalence of musculoskeletal disorders (MSDs). At many sites, musculoskeletal symptoms (MS) represent a major health-care burden, adversely affecting nurses' quality of life and giving rise to mental health issues. OBJECTIVES:This study measured the ...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1002/1348-9585.12161
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Numerous workers have participated in recovery efforts following the accident that occurred at the Tokyo Electric Power Company (TEPCO) Fukushima Daiichi Nuclear Power Plant after the Great East Japan Earthquake. These workers, belonging to various companies, have been engaged in various tasks since the acci...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.17-0150-CS
更新日期:2018-03-27 00:00:00
abstract::The relationships between alcohol consumption, serum gamma-glutamyltransferase (GGT) levels, and the prevalence of major coronary risk factors were analyzed cross-sectionally in 2,399 male and 1,402 female middle-aged workers, to clarify the effects of moderate alcohol consumption on the development of the metabolic s...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.45.293
更新日期:2003-09-01 00:00:00
abstract:OBJECTIVES:Among the many chemicals used in a hair salon, exposure to thioglycolic acid (TGA) used for permanent waving solutions (PWS) potentially causes adverse health effects. However, no report has been previously published on the indoor air concentrations of TGA in a beauty salon that contributes to assessment of ...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.12-0084-fs
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVES:Although well-being at work is important for occupational health, multi-dimensional workplace well-being measures do not exist for Japanese workers. The purpose of this study was to investigate the validity of the Japanese version of the Workplace PERMA-Profiler. METHODS:Japanese workers completed online su...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.2018-0050-OA
更新日期:2018-09-26 00:00:00
abstract:OBJECTIVE:To present the pitiable working conditions of clinical waste pickers in hospitals in the Northwest region of Cameroon and associated exposure to health hazards. METHODS:Observe clinical waste pickers as they carry out their functions for three days and carry out informal consultations (discussion) with the w...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.q9004
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVES:This study aimed to evaluate the effectiveness of supervised exercise among nurses conducting shift work for health promotion. METHODS:A total of 30 healthy female nurses conducting shift work participated in this study and they were randomly assigned to one of the following 2 groups: The supervised exercis...
journal_title:Journal of occupational health
pub_type: 杂志文章,随机对照试验
doi:10.1539/joh.16-0125-OA
更新日期:2017-07-27 00:00:00