Abstract:
OBJECTIVES:Inhalation toxicities of indium-tin oxide (ITO) and indium oxide (IO) in mice were characterized in comparison with those previously reported in rats. METHODS:B6C3F(1) mice of both sexes were exposed by inhalation to ITO or IO aerosol for 6 h/day, 5 day/wk for 2 wk at 0, 0.1, 1, 10 or 100 mg/m(3) or 13 wk at 0, 0.1or 1 mg/m(3). RESULTS:ITO and IO particles were deposited in the lung, mediastinal lymph node (MLN) and nasal-associated lymphoid tissue. Alveolar proteinosis, infiltrations of alveolar macrophages and inflammatory cells and increased lung weight were induced by 2- and 13-week exposures to ITO and IO, while alveolar epithelial hyperplasia occurred only in the 2-week exposures. Thickened pleural wall, hyperplastic MLN, extramedullary hematopoiesis in the spleen and increased levels of erythrocyte parameters were induced by 13-week exposure to ITO. The ITO- and IO-induced pulmonary lesions were milder in mice than those previously reported in rats, and the fibrotic lesions were different between these two species. Indium levels in the lung and pooled blood were analyzed in the mice exposed to ITO and IO for 13 wk. In the 13-week inhalation exposure of mice to ITO, alveolar proteinosis and significantly increased lung weight were induced at the same exposure concentration as the current threshold limit value for indium and its compounds.
journal_name
J Occup Healthjournal_title
Journal of occupational healthauthors
Nagano K,Nishizawa T,Eitaki Y,Ohnishi M,Noguchi T,Arito H,Fukushima Sdoi
10.1539/joh.10-0053-brsubject
Has Abstractpub_date
2011-01-01 00:00:00pages
234-9issue
3eissn
1341-9145issn
1348-9585pii
JST.JSTAGE/joh/10-0053-BRjournal_volume
53pub_type
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journal_title:Journal of occupational health
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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更新日期:2010-01-01 00:00:00
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doi:10.1539/joh.15-0260-OA
更新日期:2016-07-22 00:00:00
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更新日期:2005-03-01 00:00:00
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更新日期:2013-01-01 00:00:00
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更新日期:2017-07-27 00:00:00
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更新日期:2013-01-01 00:00:00
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更新日期:2007-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1539/joh.12-0192-oa
更新日期:2014-01-01 00:00:00
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journal_title:Journal of occupational health
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更新日期:2009-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2005-09-01 00:00:00
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更新日期:2018-09-26 00:00:00
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pub_type: 杂志文章
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更新日期:2004-05-01 00:00:00