Effects of chronic noise exposure on spatial learning and memory of rats in relation to neurotransmitters and NMDAR2B alteration in the hippocampus.


OBJECTIVES:The purpose of this study was to examine the effects of noise exposure on spatial learning and memory and associated mechanisms in the hippocampus (HIP). METHODS:Forty-eight male SD rats were grouped as: A, control; B, Morris water maze (MWM) training group; C, noise exposure group; and D, noise exposure followed by MWM training group. The influence of noise stress on spatial learning and memory in rats was assessed in hidden platform acquisition training and probe trial testing in MWM. Changes in morphology of Nissl bodies were observed in the CA1, CA3 and DG regions of HIP. In order to understand the possible mechanisms behind noise stress-induced changes, the concentration of amino acid neurotransmitters and the expression of NMDAR2B (NR2B) in HIP were also evaluated. RESULTS:After noise exposure, the performance of spatial learning and memory in group D was decreased significantly compared to group B. The concentration of glutamate was significantly increased in groups C and D, whereas GABA decreased markedly. The mean optical density of Nissl bodies in groups C and D was reduced in the CA1, DG and CA3 regions. The expression of NR2B was significantly decreased in the CA1, CA3 and DG regions in group C, and in the CA1 and CA3 regions in group D as compared with groups A and B. CONCLUSIONS:Excitotoxicity, impaired Nissl bodies and reduced expression of NR2B in rat HIP induced by chronic noise exposure might have caused the impairment of spatial learning and memory.


J Occup Health


Cui B,Wu M,She X




Has Abstract


2009-01-01 00:00:00














  • Mental and physical effects of Tanshin funin, posting without family, on married male workers in Japan.

    abstract::This paper investigates the effects of tanshin funin, a posting without family, on the health of married male workers. A prospective study using the pair-matched method was performed. One hundred and twenty-nine married male tanshin funin workers in their 40s and 50s and as many matched workers living with their famil...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Nakadaira H,Yamamoto M,Matsubara T

    更新日期:2006-03-01 00:00:00

  • Long-term observation of pulmonary toxicity of toner with external additives following a single intratracheal instillation in rats.

    abstract:OBJECTIVES:Along with technological innovations for improving the efficiency of printing, nanoparticles have been added to the surface of toners, and there is concern about the harmful effects of those components. We investigated, through a long-term observation following intratracheal instillation using rats, whether ...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Tomonaga T,Izumi H,Yoshiura Y,Marui T,Wang KY,Nishida C,Yatera K,Morimoto Y

    更新日期:2020-01-01 00:00:00

  • Perception in relation to a potential influenza pandemic among healthcare workers in Japan: implications for preparedness.

    abstract::Due to the potential for an influenza pandemic, preparedness for infection control in healthcare settings is essential from the standpoint of occupational health for healthcare workers. We conducted questionnaire surveys among Japanese hospitals to assess preparedness at the individual and institutional levels and the...

    journal_title:Journal of occupational health

    pub_type: 杂志文章,多中心研究


    authors: Imai T,Takahashi K,Todoroki M,Kunishima H,Hoshuyama T,Ide R,Kawasaki T,Koyama N,Endo K,Fujita H,Iwata K,Koh G,Chia SE,Koh D

    更新日期:2008-01-01 00:00:00

  • Qualitative and quantitative differences between common occupational health risk assessment models in typical industries.

    abstract:OBJECTIVE:The differences in the methodologies of various occupational health risk assessment (OHRA) models have not been extensively reported. We aimed to understand the qualitative and quantitative differences between common OHRA models in typical industries. METHODS:The Environmental Protection Agency (EPA), Austra...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Tian F,Zhang M,Zhou L,Zou H,Wang A,Hao M

    更新日期:2018-09-26 00:00:00

  • Continuous improvement of fitness-for-duty management programs for workers engaging in stabilizing and decommissioning work at the Fukushima Daiichi Nuclear Power Plant.

    abstract:BACKGROUND:Numerous workers have participated in recovery efforts following the accident that occurred at the Tokyo Electric Power Company (TEPCO) Fukushima Daiichi Nuclear Power Plant after the Great East Japan Earthquake. These workers, belonging to various companies, have been engaged in various tasks since the acci...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Mori K,Tateishi S,Kubo T,Kobayashi Y,Hiraoka K,Kawashita F,Hayashi T,Kiyomoto Y,Kobashi M,Fukai K,Tahara H,Okazaki R,Ogami A,Igari K,Suzuki K,Kikuchi H,Sakai K

    更新日期:2018-03-27 00:00:00

  • The associations between menstrual function and life style/working conditions among nurses in Taiwan.

    abstract::This study was aimed at understanding the relationship among menstrual pattern, dysmenorrhea, life style and working conditions in nurses. The nurses were randomly selected from a medical center in Northern Taiwan. Each subject completed daily records including life and working conditions during the study period. The ...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Chung FF,Yao CC,Wan GH

    更新日期:2005-03-01 00:00:00

  • Work characteristics and upper extremity disorders in female dental health workers.

    abstract::Many dental health workers suffer from musculoskeletal disorders in the upper extremities. In addition to ergonomic factors, psychosocial work characteristics have been linked to musculoskeletal disorders. The present cross-sectional study aimed at investigating how musculoskeletal disorders in the upper extremities (...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Lindfors P,von Thiele U,Lundberg U

    更新日期:2006-05-01 00:00:00

  • Acute arsine poisoning confirmed by speciation analysis of arsenic compounds in the plasma and urine by HPLC-ICP-MS.

    abstract:OBJECTIVES:Arsine, a potent hemolytic agent, is widely used in the semiconductor industry. We report a case of arsine poisoning confirmed by arsenic speciation analysis in serum and urine that occurred in a recycling factory. CASE:A male worker in his twenties noticed hematuria 3 h after finishing work and was admitte...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Yoshimura Y,Endo Y,Shimoda Y,Yamanaka K,Endo G

    更新日期:2011-01-01 00:00:00

  • Screening for hazardous drinking in migrant workers in southeastern Spain.

    abstract:OBJECTIVES:Despite the great impact the migration has had in economic, social and health-related fields, and the repercussions of alcohol consumption on them, few data exist concerning the extent of alcohol consumption in migrant workers. The aims of this study were to identify workers with a hazardous drinking problem...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Perez-Carceles MD,Medina MD,Perez-Flores D,Noguera JA,Pereniguez JE,Madrigal M,Luna A

    更新日期:2014-01-01 00:00:00

  • Association of job-related stress factors with psychological and somatic symptoms among Japanese hospital nurses: effect of departmental environment in acute care hospitals.

    abstract::The present study examined degrees of job-related stress factors as well as mental and physical symptoms among Japanese hospital nurses in various departments, and clarified associations of departments and job-related stress factors with those symptoms. A self-administered anonymous questionnaire was distributed to 1,...

    journal_title:Journal of occupational health

    pub_type: 杂志文章,多中心研究


    authors: Kawano Y

    更新日期:2008-01-01 00:00:00

  • Long working hours and sleep problems among public junior high school teachers in Japan.

    abstract:OBJECTIVES:Long working hours may impact human health. In Japan, teachers tend to work long hours. From 2002 to 2012, the number of leaves of absence due to diseases other than mental disorders, or mental disorders among public school teachers increased by 1.3 times (from 2,616 to 3,381), or 1.8 times (from 2,687 to 4,...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Bannai A,Ukawa S,Tamakoshi A

    更新日期:2015-01-01 00:00:00

  • Relationships between work-related factors and disorders in the neck-shoulder and low-back region among female and male ambulance personnel.

    abstract::This cross-sectional study on a random sample of 1,500 ambulance personnel investigated the relationships between self-reported work-related physical and psychosocial factors, worry about work conditions, and musculoskeletal disorders among female and male ambulance personnel. Three different outcomes, complaints, act...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Aasa U,Barnekow-Bergkvist M,Angquist KA,Brulin C

    更新日期:2005-11-01 00:00:00

  • Job stress and mental health of child-counseling office workers.

    abstract::In Japan, consultations concerning child abuse cases are increasing rapidly, and the mental health of child-counseling office workers, who must deal with them, has emerged as an issue. To measure the state of mental health of these workers, and to clarify the characteristics of their job-related stress, we sent a ques...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Morita N,Wada I

    更新日期:2007-03-01 00:00:00

  • Competencies required for occupational health nurses.

    abstract:OBJECTIVES:For occupational health (OH) nurses to perform activities effectively, not only skills and knowledge but also competencies proposed by Dr. McClelland are indispensable. This study aimed to identify competencies required for OH nurses and to show their structure diagram. METHODS:Qualitative descriptive resea...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Kono K,Goto Y,Hatanaka J,Yoshikawa E

    更新日期:2017-11-25 00:00:00

  • Biological monitoring method for urinary neonicotinoid insecticides using LC-MS/MS and its application to Japanese adults.

    abstract:OBJECTIVES:Agricultural use of neonicotinoid (NEO) insecticides has been increasing in recent years, but their biological monitoring methods have been scarcely reported. In this study, we developed and validated a rapid and sensitive method for quantifying urinary NEO concentrations using high-performance liquid chroma...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Ueyama J,Nomura H,Kondo T,Saito I,Ito Y,Osaka A,Kamijima M

    更新日期:2014-01-01 00:00:00

  • Personality and resilience associated with perceived fatigue of local government employees responding to disasters.

    abstract:OBJECTIVES:According to some newspapers, concerns are growing over the health of local government employees in the Great East Japan Earthquake disaster areas. Concerns were consistently present after the Hanshin-Awaji and Niigata-Chuetsu earthquakes but not studied analytically. METHODS:Municipal employees responding ...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Kitamura H,Shindo M,Tachibana A,Honma H,Someya T

    更新日期:2013-01-01 00:00:00

  • A survey on health effects in a human population exposed to permanent-waving solution containing thioglycolic acid.

    abstract::Thioglycolic acid (TGA) is the active ingredient of permanent-waving solution (PWS). TGA has been shown to be a chemical of high toxicity, which can be absorbed through intact skin and cause damage to organs or systems in animals. This study evaluated the effect of TGA-containing PWS on the health of a human populatio...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Gan HF,Meng XS,Song CH,Li BX

    更新日期:2003-11-01 00:00:00

  • Abnormalities in cadmium fluoride kinetics in serum, bile, and urine after single intravenous administration of toxic doses to rats.

    abstract::Cadmium fluoride (CdF2, CdF for short) is the most lethal and hepatotoxic of all Cd-containing compounds. The toxic effects of CdF appear to depend on its detoxification and elimination. This study was designed to determine the early dynamics of the absorption, systemic distribution, and metabolism of CdF. The kinetic...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Dote T,Adachi K,Yamadori E,Imanishi M,Tsuji H,Tanida E,Kono K

    更新日期:2008-01-01 00:00:00

  • An integrated approach for improving occupational health and safety management: the voluntary protection program in Taiwan.

    abstract::A voluntary compliance program for occupational health and safety management, Voluntary Protection Programs (VPP), was implemented with a strategy of cooperation and encouragement in Taiwan. Due to limitations on increasing the human forces of inspection, a regulatory-based guideline addressing the essence of Occupati...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Su TS,Tsai WY,Yu YC

    更新日期:2005-05-01 00:00:00

  • A biological indicator of inorganic arsenic exposure using the sum of urinary inorganic arsenic and monomethylarsonic acid concentrations.

    abstract:OBJECTIVES:The sum of urinary inorganic arsenic (iAs), monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA) concentrations is used for the biological monitoring of occupational iAs exposure. Although DMA is a major metabolite of iAs, it is an inadequate index because high DMA levels are present in urine after s...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Hata A,Kurosawa H,Endo Y,Yamanaka K,Fujitani N,Endo G

    更新日期:2016-05-25 00:00:00

  • Screening of dry eye disease in visual display terminal workers during occupational health examinations: The Moriguchi study.

    abstract:PURPOSE:The aim of this study was to estimate the prevalence of dry eye disease (DED) in Japanese visual display terminal (VDT) workers and identify simple methods for screening DED during occupational health examinations. METHODS:This study involved 369 (331 men and 38 women; mean age, 44.4 [8.8] years) workers engag...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Kawashima M,Yamatsuji M,Yokoi N,Fukui M,Ichihashi Y,Kato H,Nishida M,Uchino M,Kinoshita S,Tsubota K

    更新日期:2015-01-01 00:00:00

  • Fire risk assessment in fire hazardous zones of gasoline stations.

    abstract:OBJECTIVE:This cross-sectional study aimed to assess fire risk in fire hazardous zones (FHZ) at the dispenser areas of gasoline stations. METHODS:There were 47 stations chosen for fire risk assessment and two zones around the dispenser area of each station were assessed. The assessments were carried out by applying th...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Chaiklieng S,Dacherngkhao T,Suggaravetsiri P,Pruktharathikul V

    更新日期:2020-01-01 00:00:00

  • The association of work-related stressors and their changes over time with the development of metabolic syndrome: The Furukawa Nutrition and Health Study.

    abstract:OBJECTIVE:To investigate associations of work-related stressors and their changes over time with the risk of developing metabolic syndrome (MetS) among Japanese manufacturing workers. METHODS:Participants were 1,040 employees aged 19 to 68 years who were free from MetS at baseline and completed the three year-interval...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Yamaguchi M,Eguchi M,Akter S,Kochi T,Hu H,Kashino I,Kuwahara K,Kabe I,Mizoue T

    更新日期:2018-11-27 00:00:00

  • Relationships between body mass index, lifestyle habits, and locomotive syndrome in young- and middle-aged adults: A cross-sectional survey of workers in Japan.

    abstract:OBJECTIVES:Although many studies have examined locomotive syndrome (LS) among elderly people, few studies have examined LS in young- and middle-aged adults. This study aimed to provide basic data on the epidemiological characteristics of LS, including in young- and middle-aged adults. METHOD:We conducted a cross-secti...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Ohtsuki M,Nishimura A,Kato T,Sokejima S,Shibata T,Okada H,Nagao-Nishiwaki R,Sudo A

    更新日期:2019-07-01 00:00:00

  • Aberrant promoter methylation of p16(INK4a) and O(6)-methylguanine-DNA methyltransferase genes in workers at a Chinese uranium mine.

    abstract::To find the possible association of gene methylation of p16(INK4a) and O(6)-Methylguanine-DNA Methyltransferase (O(6)-MGMT) with occupational exposure to radon, 91 male miners from a uranium mine in China were divided into 4 groups according to the cumulative doses of radon exposure from 2 to 425 WLM (working-level mo...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Su S,Jin Y,Zhang W,Yang L,Shen Y,Cao Y,Tong J

    更新日期:2006-07-01 00:00:00

  • Possible changes of New-Generation inflammation markers with occupational lead exposure.

    abstract:OBJECTIVES:Occupational lead (Pb) exposure is still an important health problem in the world. Long-term Pb exposure causes several adverse effects. The aim of this study was to investigate the changes of inflammation markers with chronic Pb exposure by analyzing neopterin levels and kynurenine (Kyn) to tryptophan (Trp)...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Sipahi H,Girgin G,Palabiyik SS,Tutkun E,Yilmaz OH,Baydar T

    更新日期:2017-07-27 00:00:00

  • Effects of co-exposure to noise and mixture of organic solvents on blood pressure.

    abstract:OBJECTIVES:Independent exposure to noise or organic solvents is reported to be associated with cardiovascular effects, but the effect of joint exposure is unclear. The present study aimed to investigate effects of noise, a mixture of organic solvents (N,N-dimethylformamide (DMF) and toluene) and their interaction on hy...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Chang TY,Wang VS,Hwang BF,Yen HY,Lai JS,Liu CS,Lin SY

    更新日期:2009-01-01 00:00:00

  • Patterns of outpatient visits by Japanese male expatriates in Thailand.

    abstract::Objective of this study is to clarify the health-related conditions of Japanese male expatriates in Thailand. Records of Japanese male expatriates in their 30s to 50s who consulted outpatient clinics at Bangkok Hospital in 2005 were analyzed for number and type of outpatient visits then compared with data from the "Pa...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Sakai R,Wongkhomthong SA,Marui E,Laobhripatr S

    更新日期:2008-01-01 00:00:00

  • Changes in health habits of female shift workers.

    abstract::This paper examines the effects of shift work on the lifestyles of female factory workers. As an indicator of healthy lifestyle habits, we used a scoring system (referred to below as the 'health score') based on Lester Breslow's health habits. The 'health score' of the women was higher than that of the men, but the sh...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Kaneko SY,Maeda T,Sasaki A,Sato A,Tanaka K,Kobayashi T,Tanaka M,Fukushima T

    更新日期:2004-05-01 00:00:00

  • Work-related respiratory symptoms and ventilatory disorders among employees of a cement industry in Shiraz, Iran.

    abstract::Although the main hazard in cement processing is dust and respiratory tract disorders are the most important group of occupational diseases in this industry, evidence for associations between exposure to cement dust and either respiratory symptoms or functional impairment has not been conclusive. This study was, there...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Neghab M,Choobineh A

    更新日期:2007-07-01 00:00:00