Abstract:
OBJECTIVES:The purpose of this study was to examine the effects of noise exposure on spatial learning and memory and associated mechanisms in the hippocampus (HIP). METHODS:Forty-eight male SD rats were grouped as: A, control; B, Morris water maze (MWM) training group; C, noise exposure group; and D, noise exposure followed by MWM training group. The influence of noise stress on spatial learning and memory in rats was assessed in hidden platform acquisition training and probe trial testing in MWM. Changes in morphology of Nissl bodies were observed in the CA1, CA3 and DG regions of HIP. In order to understand the possible mechanisms behind noise stress-induced changes, the concentration of amino acid neurotransmitters and the expression of NMDAR2B (NR2B) in HIP were also evaluated. RESULTS:After noise exposure, the performance of spatial learning and memory in group D was decreased significantly compared to group B. The concentration of glutamate was significantly increased in groups C and D, whereas GABA decreased markedly. The mean optical density of Nissl bodies in groups C and D was reduced in the CA1, DG and CA3 regions. The expression of NR2B was significantly decreased in the CA1, CA3 and DG regions in group C, and in the CA1 and CA3 regions in group D as compared with groups A and B. CONCLUSIONS:Excitotoxicity, impaired Nissl bodies and reduced expression of NR2B in rat HIP induced by chronic noise exposure might have caused the impairment of spatial learning and memory.
journal_name
J Occup Healthjournal_title
Journal of occupational healthauthors
Cui B,Wu M,She Xdoi
10.1539/joh.l8084subject
Has Abstractpub_date
2009-01-01 00:00:00pages
152-8issue
2eissn
1341-9145issn
1348-9585pii
JST.JSTAGE/joh/L8084journal_volume
51pub_type
杂志文章abstract:OBJECTIVES:Inhalation toxicities of indium-tin oxide (ITO) and indium oxide (IO) in mice were characterized in comparison with those previously reported in rats. METHODS:B6C3F(1) mice of both sexes were exposed by inhalation to ITO or IO aerosol for 6 h/day, 5 day/wk for 2 wk at 0, 0.1, 1, 10 or 100 mg/m(3) or 13 wk a...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.10-0053-br
更新日期:2011-01-01 00:00:00
abstract::This study was conducted on a thermal exposure chamber designed for assessing workers' thermal hazard. In order to assess the efficacy of the studied chamber, three environmental conditions were selected to simulate high, middle and low thermal impact situations, with air temperatures (Ta) of 43.12, 36.23 and 25.77 ma...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.45.153
更新日期:2003-05-01 00:00:00
abstract:OBJECTIVES:Along with technological innovations for improving the efficiency of printing, nanoparticles have been added to the surface of toners, and there is concern about the harmful effects of those components. We investigated, through a long-term observation following intratracheal instillation using rats, whether ...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1002/1348-9585.12146
更新日期:2020-01-01 00:00:00
abstract::Systemic effects of p, p'-DDE (1, 1-dichloro-2, 2 bis (p-chlorophenyl) ethylene; DDE) on immature male rats were investigated in pubertal Wistar rats after oral administration of DDE. Special rat chow containing 125 ppm DDE (approximately 10 mg/kg DDE) had been administered daily for 42 d since 6 wk of age and its eff...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.45.223
更新日期:2003-07-01 00:00:00
abstract::This study prospectively examined the association between perceived noise exposure at work and cerebrovascular diseases among Japanese male workers. A baseline survey was conducted between 1988 and 1990, which involved 110,792 inhabitants (age range: 40-79 yr) from 45 areas throughout Japan. Subsequent causes of death...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.49.382
更新日期:2007-09-01 00:00:00
abstract::Although the main hazard in cement processing is dust and respiratory tract disorders are the most important group of occupational diseases in this industry, evidence for associations between exposure to cement dust and either respiratory symptoms or functional impairment has not been conclusive. This study was, there...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.49.273
更新日期:2007-07-01 00:00:00
abstract:OBJECTIVES:The aim of this meta-analysis is to investigate to what extent vacation has positive effects on health and well-being, how long such effects endure after work resumption, and how specific vacation activities and experiences affect these relationships. METHODS:Based on a systematic literature search (PsycInf...
journal_title:Journal of occupational health
pub_type: 杂志文章,meta分析,评审
doi:10.1539/joh.k8004
更新日期:2009-01-01 00:00:00
abstract::Cadmium fluoride (CdF2, CdF for short) is the most lethal and hepatotoxic of all Cd-containing compounds. The toxic effects of CdF appear to depend on its detoxification and elimination. This study was designed to determine the early dynamics of the absorption, systemic distribution, and metabolism of CdF. The kinetic...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.l8016
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVES:Polychlorinated biphenyls (PCBs) are considered probable human carcinogens by the International Agency for Research on Cancer and one congener, PCB126, has been rated as a known human carcinogen. A period-specific job exposure matrix (JEM) was developed for former PCB-exposed capacitor manufacturing workers ...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.l9151
更新日期:2010-01-01 00:00:00
abstract:PURPOSE:The aim of this study was to estimate the prevalence of dry eye disease (DED) in Japanese visual display terminal (VDT) workers and identify simple methods for screening DED during occupational health examinations. METHODS:This study involved 369 (331 men and 38 women; mean age, 44.4 [8.8] years) workers engag...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.14-0243-OA
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVES:To develop tools offering definite orientation for managers and employees to support their work improvement through occupational mental health. This research was a part of the Mental Health Improvement & Reinforcement Study (MIR study), conducted from October 2004 to March 2006. METHODS:We developed a trial...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.l8081
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Healthcare workers are at high risk of infection from blood-borne pathogens, such as Hepatitis B and C Virus, and Human Immunodeficiency. Occupational exposure to needle-stick injuries (NSIs) continue to have a major health problem in the healthcare systems of developing countries. Thus, this review article ...
journal_title:Journal of occupational health
pub_type: 杂志文章,评审
doi:10.1002/1348-9585.12179
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:This study aimed to evaluate the efficacy of increased daily walking steps on the 6-month incidence of neck pain among office workers. METHODS:Healthy office workers with high risk of neck pain were recruited into a 6-month prospective cluster-randomized controlled trial. Participants were randomly assigned ...
journal_title:Journal of occupational health
pub_type: 杂志文章,随机对照试验
doi:10.1002/1348-9585.12106
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:The aim of this review was to summarize the lessons learned from the experience in protecting the health of workers engaged in operations following the accident at the Fukushima Daiichi Nuclear Power Plant (NPP). METHODS:We reviewed all types of scientific papers examining workers' health found in Medline a...
journal_title:Journal of occupational health
pub_type: 杂志文章,评审
doi:10.1539/joh.15-0084-RA
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Petrochemical industries are known as sources of many toxic chemicals. Safety and health risks of the petrochemical workers employed at Map Ta Phut Industrial Estate, located in Rayong, Thailand, are potentially high. METHODS:The research materials consisted of documents emanating from statutory reports on ...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.11-0091-oa
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVES:Professional drivers are exposed to diesel engine exhaust and outdoor air pollution while driving. Diesel engine exhaust and outdoor air pollution are known carcinogens causing lung cancer. However, previous epidemiological studies examining lung cancer risk in professional drivers have not shown a consisten...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.14-0222-OA
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:Working long hours is a potential health hazard. Although self-reporting of working hours in various time frames has been used in epidemiologic studies, its validity is unclear. The objective of this study was to examine the validity and reproducibility of self-reported working hours among Japanese male emplo...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.15-0260-OA
更新日期:2016-07-22 00:00:00
abstract:OBJECTIVE:The purpose of this study was to investigate the effects of Nickel (Ni) -smelting fumes on oncogenic proteins in vivo and in vitro. METHODS:Ni fallout beside a Ni smelting furnace in a factory was sampled to study its toxic effect. The effects of Ni-smelting fumes on the regulation of PI3K and ERK signaling ...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.15-0287-OA
更新日期:2016-09-30 00:00:00
abstract:OBJECTIVES:Spinal pain is a significant occupational health issue. Whilst neck pain and low back pain have received considerable attention, thoracic spinal pain (TSP) has not. The objective of this study was to systematically identify and report the evidence describing the prevalence and correlates of TSP within occupa...
journal_title:Journal of occupational health
pub_type: 杂志文章,评审
doi:10.1539/joh.k8007
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVES:The aims of this study were to develop approaches for monitoring and prioritizing factors associated with thermal stresses imposed on workers in iron and steel casting industries, and to eventually purpose effective control strategies. METHODS:The whole study was completed in the furnace areas of two steel ...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.14-0078-FS
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVES:This study aimed to investigate the association between occupational clusters and allergic rhinitis (AR). METHODS:The study was based on data from the Korean National Health and Nutrition Examination Survey (KNHANES: 2007-2015). This study included 46,965 individuals: 20,491 men and 26,474 women. AR was def...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.2017-0234-OA
更新日期:2018-07-25 00:00:00
abstract::This review provides perspectives on cardiovascular occupational stress research since the 1960s until now. The author argues for closer links between basic science and clinical follow-up examinations of patients. In an excellent way urinary excretion of adrenaline and noradrenaline during wake hours mirrors day to da...
journal_title:Journal of occupational health
pub_type: 杂志文章,评审
doi:10.1002/1348-9585.12032
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to examine changes in working hours, shift work, psychological and physical job demands, job control and job insecurity in Taiwanese employees by gender and age during the period of 2001 to 2010. METHODS:The study subjects were 36,750 men and 27,549 women, aged 25-64, from 4 rounds ...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.12-0286-oa
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Numerous workers have participated in recovery efforts following the accident that occurred at the Tokyo Electric Power Company (TEPCO) Fukushima Daiichi Nuclear Power Plant after the Great East Japan Earthquake. These workers, belonging to various companies, have been engaged in various tasks since the acci...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.17-0150-CS
更新日期:2018-03-27 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate the association between skill underutilization, a psychological job stressor proposed in the NIOSH (National Institute for Occupational Safety and Health) job stress model, and the prevalence of hypertension. METHODS:We studied sitting blood pressure and fasting bloo...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.13-0146-br
更新日期:2014-01-01 00:00:00
abstract::To find the possible association of gene methylation of p16(INK4a) and O(6)-Methylguanine-DNA Methyltransferase (O(6)-MGMT) with occupational exposure to radon, 91 male miners from a uranium mine in China were divided into 4 groups according to the cumulative doses of radon exposure from 2 to 425 WLM (working-level mo...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.48.261
更新日期:2006-07-01 00:00:00
abstract:OBJECTIVE:This cross-sectional study aimed to assess fire risk in fire hazardous zones (FHZ) at the dispenser areas of gasoline stations. METHODS:There were 47 stations chosen for fire risk assessment and two zones around the dispenser area of each station were assessed. The assessments were carried out by applying th...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1002/1348-9585.12137
更新日期:2020-01-01 00:00:00
abstract:BACKGROUNDS:Two-component acrylic resin used in nail art and dentistry can cause allergic contact dermatitis (ACD), but only a few reports from Japan have been published. CASES:A 35-year-old female manicurist (case 1) and 30-year-old female dental hygienist (case 2) were diagnosed with ACD caused by ethyl methacrylate...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.13-0244-cs
更新日期:2014-01-01 00:00:00
abstract::This study presents the results of an investigation of respiratory symptoms, pulmonary function and chest X-ray examinations, and analysis of antibodies to fungi of 197 tussah silk-processing workers and 40 control workers. An industrial hygiene survey and environmental mycological studies were also conducted. The dus...
journal_title:Journal of occupational health
pub_type: 临床试验,杂志文章
doi:10.1539/joh.46.418
更新日期:2004-09-01 00:00:00
abstract:OBJECTIVES:Although well-being at work is important for occupational health, multi-dimensional workplace well-being measures do not exist for Japanese workers. The purpose of this study was to investigate the validity of the Japanese version of the Workplace PERMA-Profiler. METHODS:Japanese workers completed online su...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.2018-0050-OA
更新日期:2018-09-26 00:00:00