Genotoxicity studies of heavy metals: lead, bismuth, indium, silver and antimony.


OBJECTIVES:Many kinds of heavy metals are used in industry; thus, it is important for us to clarify their toxicity. For example, lead, which is a component of solder, is notorious for its neurotoxicity, and substitute materials have been sought for many years. Therefore, we examined the genotoxicity of lead and also those of metallic bismuth, indium, silver and antimony which are possible substitutes for lead in solder. METHODS:Bacterial reverse mutation tests and chromosomal aberration tests in cultured mammalian cells were performed according to standard procedures. RESULTS:Antimony showed genotoxicity in both tests, and bismuth also showed positive results in the chromosomal aberration test. In contrast, lead, indium, and silver were considered to be inactive by the criteria of the present study. CONCLUSIONS:Although further studies are needed because of the difficulty of genotoxicity evaluation using an in vitro system, sufficient precautions should be made when antimony and bismuth are used.


J Occup Health


Asakura K,Satoh H,Chiba M,Okamoto M,Serizawa K,Nakano M,Omae K




Has Abstract


2009-01-01 00:00:00














  • Evaluating the efficacy of a thermal exposure chamber designed for assessing workers' thermal hazard.

    abstract::This study was conducted on a thermal exposure chamber designed for assessing workers' thermal hazard. In order to assess the efficacy of the studied chamber, three environmental conditions were selected to simulate high, middle and low thermal impact situations, with air temperatures (Ta) of 43.12, 36.23 and 25.77 ma...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Tsai PJ,Lo CL,Sun YM,Juang YJ,Liu HH,Chen WY,Yeh WY

    更新日期:2003-05-01 00:00:00

  • Effects of chronic noise exposure on spatial learning and memory of rats in relation to neurotransmitters and NMDAR2B alteration in the hippocampus.

    abstract:OBJECTIVES:The purpose of this study was to examine the effects of noise exposure on spatial learning and memory and associated mechanisms in the hippocampus (HIP). METHODS:Forty-eight male SD rats were grouped as: A, control; B, Morris water maze (MWM) training group; C, noise exposure group; and D, noise exposure fo...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Cui B,Wu M,She X

    更新日期:2009-01-01 00:00:00

  • Prevalence and associated factors for thoracic spine pain in the adult working population: a literature review.

    abstract:OBJECTIVES:Spinal pain is a significant occupational health issue. Whilst neck pain and low back pain have received considerable attention, thoracic spinal pain (TSP) has not. The objective of this study was to systematically identify and report the evidence describing the prevalence and correlates of TSP within occupa...

    journal_title:Journal of occupational health

    pub_type: 杂志文章,评审


    authors: Briggs AM,Bragge P,Smith AJ,Govil D,Straker LM

    更新日期:2009-01-01 00:00:00

  • Nickel-smelting fumes increased the expression of HIF-1α through PI3K/ERK pathway in NIH/3T3 cells.

    abstract:OBJECTIVE:The purpose of this study was to investigate the effects of Nickel (Ni) -smelting fumes on oncogenic proteins in vivo and in vitro. METHODS:Ni fallout beside a Ni smelting furnace in a factory was sampled to study its toxic effect. The effects of Ni-smelting fumes on the regulation of PI3K and ERK signaling ...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Han D,Yang Y,Zhang L,Wang C,Wang Y,Tan WQ,Hu XY,Wu YH

    更新日期:2016-09-30 00:00:00

  • Distribution of airborne bacteria in railway stations in Tokyo, Japan.

    abstract:OBJECTIVES:We performed the current study to (1) understand the distribution of culturable airborne bacteria over a one-year monitoring period, (2) confirm places in stations where airborne bacteria are highly detected, (3) understand the factors that affect concentrations of airborne bacteria and (4) compare the distr...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Kawasaki T,Kyotani T,Ushiogi T,Lee H

    更新日期:2013-01-01 00:00:00

  • Association between occupational clusters and allergic rhinitis in the Korean population: analysis of the Korean National Health and Nutrition Examination Survey data.

    abstract:OBJECTIVES:This study aimed to investigate the association between occupational clusters and allergic rhinitis (AR). METHODS:The study was based on data from the Korean National Health and Nutrition Examination Survey (KNHANES: 2007-2015). This study included 46,965 individuals: 20,491 men and 26,474 women. AR was def...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Park S,Jung PK,Choi M,Seok H,Kim H,Oh SS,Koh SB

    更新日期:2018-07-25 00:00:00

  • How job demands affect an intimate partner: a test of the spillover-crossover model in Japan.

    abstract:OBJECTIVES:The present study examined how job demands affect an intimate partner's well-being. We hypothesized that job demands have a negative influence on partner well-being through the experience of work-family conflict (WFC) and an impaired quality of the relationship (reduced social support and increased social un...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Shimazu A,Bakker AB,Demerouti E

    更新日期:2009-01-01 00:00:00

  • Effects of fatigue on immune function in nurses performing shift work.

    abstract:OBJECTIVES:We investigated the effects of fatigue on NK cell function and lymphocyte subpopulations in nurses performing shift work using a longitudinal design. METHODS:Fifty-seven female nurses engaged in shift work at a hospital in Japan were selected for our study cohort. The hospital used a counterclockwise rotati...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Nagai M,Morikawa Y,Kitaoka K,Nakamura K,Sakurai M,Nishijo M,Hamazaki Y,Maruzeni S,Nakagawa H

    更新日期:2011-01-01 00:00:00

  • Comparison of single or multiple intratracheal administration for pulmonary toxic responses of nickel oxide nanoparticles in rats.

    abstract:OBJECTIVES:In this study, we focused on the qualitative and quantitative differences of the lung lesions induced by single or multiple intratracheal administration of nickel oxide nanoparticles (NiO). METHODS:Male rats were randomized into groups receiving intratracheal administrations in a single dose or two to four ...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Senoh H,Kano H,Suzuki M,Ohnishi M,Kondo H,Takanobu K,Umeda Y,Aiso S,Fukushima S

    更新日期:2017-03-28 00:00:00

  • A survey on health effects in a human population exposed to permanent-waving solution containing thioglycolic acid.

    abstract::Thioglycolic acid (TGA) is the active ingredient of permanent-waving solution (PWS). TGA has been shown to be a chemical of high toxicity, which can be absorbed through intact skin and cause damage to organs or systems in animals. This study evaluated the effect of TGA-containing PWS on the health of a human populatio...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Gan HF,Meng XS,Song CH,Li BX

    更新日期:2003-11-01 00:00:00

  • Mental health of working-age populations in Japan who provide nursing care for a person at home: A cross-sectional analysis.

    abstract:OBJECTIVES:This study investigated potential associations between having a person in need of nursing care at home and psychological distress amongst the Japanese working population, using a nationally representative sample. METHODS:We extracted data from the 2013 Comprehensive Survey of Living Conditions conducted by ...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Eguchi H,Wada K

    更新日期:2018-11-27 00:00:00

  • Perception in relation to a potential influenza pandemic among healthcare workers in Japan: implications for preparedness.

    abstract::Due to the potential for an influenza pandemic, preparedness for infection control in healthcare settings is essential from the standpoint of occupational health for healthcare workers. We conducted questionnaire surveys among Japanese hospitals to assess preparedness at the individual and institutional levels and the...

    journal_title:Journal of occupational health

    pub_type: 杂志文章,多中心研究


    authors: Imai T,Takahashi K,Todoroki M,Kunishima H,Hoshuyama T,Ide R,Kawasaki T,Koyama N,Endo K,Fujita H,Iwata K,Koh G,Chia SE,Koh D

    更新日期:2008-01-01 00:00:00

  • Moderating effects of psychological job strain on the relationship between working hours and health: an examination of white-collar workers employed by a Japanese manufacturing company.

    abstract::The effects of working hours on health were examined taking psychological job strain into account. White-collar workers employed at the main office of a Japanese manufacturing company provided data for analysis done in 1997. The eligible subjects were 286 workers aged 20-39. Causal relationships between working hours,...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Tarumi K,Hagihara A,Morimoto K

    更新日期:2004-09-01 00:00:00

  • Aberrant promoter methylation of p16(INK4a) and O(6)-methylguanine-DNA methyltransferase genes in workers at a Chinese uranium mine.

    abstract::To find the possible association of gene methylation of p16(INK4a) and O(6)-Methylguanine-DNA Methyltransferase (O(6)-MGMT) with occupational exposure to radon, 91 male miners from a uranium mine in China were divided into 4 groups according to the cumulative doses of radon exposure from 2 to 425 WLM (working-level mo...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Su S,Jin Y,Zhang W,Yang L,Shen Y,Cao Y,Tong J

    更新日期:2006-07-01 00:00:00

  • Changes over time in pulmonary inflammatory response in rat lungs after intratracheal instillation of nickel oxide nanoparticles.

    abstract:OBJECTIVE:Nickel oxide nanoparticles (NiONPs) are representative metal oxide NPs and are categorized as an insoluble nickel compound. Our previous studies suggested that NiONPs have more pulmonary toxicity than micron-sized NiO because they may dissolve slowly and produce many more Ni ions. We confirmed the hypothesis ...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Nishi KI,Kadoya C,Ogami A,Oyabu T,Morimoto Y,Ueno S,Myojo T

    更新日期:2020-01-01 00:00:00

  • Development of a retrospective job exposure matrix for PCB-exposed workers in capacitor manufacturing.

    abstract:OBJECTIVES:Polychlorinated biphenyls (PCBs) are considered probable human carcinogens by the International Agency for Research on Cancer and one congener, PCB126, has been rated as a known human carcinogen. A period-specific job exposure matrix (JEM) was developed for former PCB-exposed capacitor manufacturing workers ...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Hopf NB,Waters MA,Ruder AM,Prince MM

    更新日期:2010-01-01 00:00:00

  • Measurement of concentrations of thioglycolic acid, dithiodiglycolic acid and ammonia in indoor air of a beauty salon.

    abstract:OBJECTIVES:Among the many chemicals used in a hair salon, exposure to thioglycolic acid (TGA) used for permanent waving solutions (PWS) potentially causes adverse health effects. However, no report has been previously published on the indoor air concentrations of TGA in a beauty salon that contributes to assessment of ...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Oikawa D,Takeuchi W,Murata S,Takahashi K,Sekine Y

    更新日期:2012-01-01 00:00:00

  • The usefulness of sleep apnea syndrome screening using a portable pulse oximeter in the workplace.

    abstract::Sleep Apnea Syndrome (SAS) is a condition characterized by sleep-disordered breathing resulting in health impairment and sleep problems. From the viewpoints of the prevention of health impairment, accidents at work and traffic accidents, active implementation of screening for SAS in workplaces is necessary. Using a po...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Niijima K,Enta K,Hori H,Sashihara S,Mizoue T,Morimoto Y

    更新日期:2007-01-01 00:00:00

  • Long working hours and sleep problems among public junior high school teachers in Japan.

    abstract:OBJECTIVES:Long working hours may impact human health. In Japan, teachers tend to work long hours. From 2002 to 2012, the number of leaves of absence due to diseases other than mental disorders, or mental disorders among public school teachers increased by 1.3 times (from 2,616 to 3,381), or 1.8 times (from 2,687 to 4,...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Bannai A,Ukawa S,Tamakoshi A

    更新日期:2015-01-01 00:00:00

  • Environmental mycological study and respiratory disease investigation in tussah silk processing workers.

    abstract::This study presents the results of an investigation of respiratory symptoms, pulmonary function and chest X-ray examinations, and analysis of antibodies to fungi of 197 tussah silk-processing workers and 40 control workers. An industrial hygiene survey and environmental mycological studies were also conducted. The dus...

    journal_title:Journal of occupational health

    pub_type: 临床试验,杂志文章


    authors: Chen J,Shi J,Wang S,Yang S,Lou J,Liu Z

    更新日期:2004-09-01 00:00:00

  • Effects of co-exposure to noise and mixture of organic solvents on blood pressure.

    abstract:OBJECTIVES:Independent exposure to noise or organic solvents is reported to be associated with cardiovascular effects, but the effect of joint exposure is unclear. The present study aimed to investigate effects of noise, a mixture of organic solvents (N,N-dimethylformamide (DMF) and toluene) and their interaction on hy...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Chang TY,Wang VS,Hwang BF,Yen HY,Lai JS,Liu CS,Lin SY

    更新日期:2009-01-01 00:00:00

  • Competencies required for occupational health nurses.

    abstract:OBJECTIVES:For occupational health (OH) nurses to perform activities effectively, not only skills and knowledge but also competencies proposed by Dr. McClelland are indispensable. This study aimed to identify competencies required for OH nurses and to show their structure diagram. METHODS:Qualitative descriptive resea...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Kono K,Goto Y,Hatanaka J,Yoshikawa E

    更新日期:2017-11-25 00:00:00

  • The associations between menstrual function and life style/working conditions among nurses in Taiwan.

    abstract::This study was aimed at understanding the relationship among menstrual pattern, dysmenorrhea, life style and working conditions in nurses. The nurses were randomly selected from a medical center in Northern Taiwan. Each subject completed daily records including life and working conditions during the study period. The ...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Chung FF,Yao CC,Wan GH

    更新日期:2005-03-01 00:00:00

  • Continuous improvement of fitness-for-duty management programs for workers engaging in stabilizing and decommissioning work at the Fukushima Daiichi Nuclear Power Plant.

    abstract:BACKGROUND:Numerous workers have participated in recovery efforts following the accident that occurred at the Tokyo Electric Power Company (TEPCO) Fukushima Daiichi Nuclear Power Plant after the Great East Japan Earthquake. These workers, belonging to various companies, have been engaged in various tasks since the acci...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Mori K,Tateishi S,Kubo T,Kobayashi Y,Hiraoka K,Kawashita F,Hayashi T,Kiyomoto Y,Kobashi M,Fukai K,Tahara H,Okazaki R,Ogami A,Igari K,Suzuki K,Kikuchi H,Sakai K

    更新日期:2018-03-27 00:00:00

  • Qualitative and quantitative differences between common occupational health risk assessment models in typical industries.

    abstract:OBJECTIVE:The differences in the methodologies of various occupational health risk assessment (OHRA) models have not been extensively reported. We aimed to understand the qualitative and quantitative differences between common OHRA models in typical industries. METHODS:The Environmental Protection Agency (EPA), Austra...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Tian F,Zhang M,Zhou L,Zou H,Wang A,Hao M

    更新日期:2018-09-26 00:00:00

  • Work-related stress and urinary catecholamines among laboratory technicians.

    abstract:OBJECTIVES:Work-related psychosocial hazards are associated with adverse health outcomes among workers. The association between psychosocial hazards and physiological health outcomes among laboratory technicians has not been studied previously. The objective of this study was to measure the association between work-rel...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Ghaddar A,Omar KH,Dokmak M,Kansour NA,Jbara Z,Laham S,Ali S

    更新日期:2014-01-01 00:00:00

  • Long-term changes in the perception of job characteristics: results from the Belstress II--study.

    abstract::The aim was to explore long-term changes in the perception of job characteristics--based on the Job Content Questionnaire (JCQ)--in view of the changing labor market in Western societies. A total number of 2,821 workers from nine companies were involved in the longitudinal Belstress-project. Data were gathered on two ...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Clays E,De Bacquer D,Leynen F,Kornitzer M,Kittel F,De Backer G

    更新日期:2006-09-01 00:00:00

  • Determining of crystalline silica in respirable dust samples by infrared spectrophotometry in the presence of interferences.

    abstract::Infrared Spectrophotometry (IR) is now widely used to determine crystalline silica in industrial dust samples. Though the IR method has many advantages when dealing with respirable dust samples, some serious analytical errors are often caused by interference minerals contamination. These minerals have a characteristic...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Ojima J

    更新日期:2003-03-01 00:00:00

  • Acute arsine poisoning confirmed by speciation analysis of arsenic compounds in the plasma and urine by HPLC-ICP-MS.

    abstract:OBJECTIVES:Arsine, a potent hemolytic agent, is widely used in the semiconductor industry. We report a case of arsine poisoning confirmed by arsenic speciation analysis in serum and urine that occurred in a recycling factory. CASE:A male worker in his twenties noticed hematuria 3 h after finishing work and was admitte...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Yoshimura Y,Endo Y,Shimoda Y,Yamanaka K,Endo G

    更新日期:2011-01-01 00:00:00

  • Mental and physical effects of Tanshin funin, posting without family, on married male workers in Japan.

    abstract::This paper investigates the effects of tanshin funin, a posting without family, on the health of married male workers. A prospective study using the pair-matched method was performed. One hundred and twenty-nine married male tanshin funin workers in their 40s and 50s and as many matched workers living with their famil...

    journal_title:Journal of occupational health

    pub_type: 杂志文章


    authors: Nakadaira H,Yamamoto M,Matsubara T

    更新日期:2006-03-01 00:00:00