Abstract:
OBJECTIVES:Many kinds of heavy metals are used in industry; thus, it is important for us to clarify their toxicity. For example, lead, which is a component of solder, is notorious for its neurotoxicity, and substitute materials have been sought for many years. Therefore, we examined the genotoxicity of lead and also those of metallic bismuth, indium, silver and antimony which are possible substitutes for lead in solder. METHODS:Bacterial reverse mutation tests and chromosomal aberration tests in cultured mammalian cells were performed according to standard procedures. RESULTS:Antimony showed genotoxicity in both tests, and bismuth also showed positive results in the chromosomal aberration test. In contrast, lead, indium, and silver were considered to be inactive by the criteria of the present study. CONCLUSIONS:Although further studies are needed because of the difficulty of genotoxicity evaluation using an in vitro system, sufficient precautions should be made when antimony and bismuth are used.
journal_name
J Occup Healthjournal_title
Journal of occupational healthauthors
Asakura K,Satoh H,Chiba M,Okamoto M,Serizawa K,Nakano M,Omae Kdoi
10.1539/joh.l9080subject
Has Abstractpub_date
2009-01-01 00:00:00pages
498-512issue
6eissn
1341-9145issn
1348-9585pii
JST.JSTAGE/joh/L9080journal_volume
51pub_type
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更新日期:2018-09-26 00:00:00
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更新日期:2018-09-26 00:00:00
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doi:10.1539/joh.17-0311-RA
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doi:10.1539/joh.49.273
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更新日期:2020-01-01 00:00:00
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