Abstract:
OBJECTIVES:Allyl nitrile (3-butenenitrile) occurs naturally in the environment, in particular, in cruciferous vegetables, indicating a possible daily intake of the compound. There is no report on actual health effects of allyl nitrile in humans, although it is possible that individuals in the environment are at a risk of exposure to allyl nitrile. However, little is known about its quantitative assessment for the environment and bioactivity in the body. This study provides a review of previous accumulated studies on allyl nitrile. METHODS:Published literature on allyl nitrile was examined for findings on toxicity, metabolism, risk of various cancers, generation, intake estimates, and low-dose effects in the body. RESULTS:High doses of allyl nitrile produce toxicity characterized by behavioral abnormalities, which are considered to be produced by an active metabolite, 3,4-epoxybutyronitrile. Cruciferous vegetables have been shown to have a potential role in reducing various cancers. Hydrolysis of the glucosinolate sinigrin, rich in cruciferous vegetables, results in the generation of allyl nitrile. An intake of allyl nitrile is estimated at 0.12 μmol/kg body weight in Japan. Repeated exposure to low doses of allyl nitrile upregulates antioxidant/phase II enzymes in various tissues; this may contribute to a reduction in neurotoxicity and skin inflammation. These high and low doses are far more than the intake estimate. CONCLUSION:Allyl nitrile in the environment is a compound with diverse bioactivities in the body, characterized by inducing behavioral abnormalities at high doses and some antioxidant/phase II enzymes at low doses.
journal_name
J Occup Healthjournal_title
Journal of occupational healthauthors
Tanii Hdoi
10.1539/joh.16-0147-RAsubject
Has Abstractpub_date
2017-03-28 00:00:00pages
104-111issue
2eissn
1341-9145issn
1348-9585journal_volume
59pub_type
杂志文章,评审abstract:OBJECTIVES:This field study aimed to determine the incidence and distribution of needlestick injuries among medical trainees at a community teaching hospital in Toronto, Canada. METHODS:The study was performed during the 2013-2015 academic years at Toronto East General Hospital (TEGH), a University of Toronto-affiliat...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.15-0253-FS
更新日期:2017-01-24 00:00:00
abstract::The relationships between alcohol consumption, serum gamma-glutamyltransferase (GGT) levels, and the prevalence of major coronary risk factors were analyzed cross-sectionally in 2,399 male and 1,402 female middle-aged workers, to clarify the effects of moderate alcohol consumption on the development of the metabolic s...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.45.293
更新日期:2003-09-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to develop and validate a simple and reliable gas chromatography-mass spectrometry (GC-MS) method to simultaneously determine urinary 1-naphthol (1-NAP) and 2-naphthol (2-NAP) for biological monitoring of occupational exposure to naphthalene. METHODS:NAPs were derivatized in situ w...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1002/1348-9585.12144
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:Among the many chemicals used in a hair salon, exposure to thioglycolic acid (TGA) used for permanent waving solutions (PWS) potentially causes adverse health effects. However, no report has been previously published on the indoor air concentrations of TGA in a beauty salon that contributes to assessment of ...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.12-0084-fs
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Nurses are one of the population groups with the highest prevalence of musculoskeletal disorders (MSDs). At many sites, musculoskeletal symptoms (MS) represent a major health-care burden, adversely affecting nurses' quality of life and giving rise to mental health issues. OBJECTIVES:This study measured the ...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1002/1348-9585.12161
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:There are high levels of global and national underemployment, but limited information is available on the impact of this phenomenon on the quality of employees' working lives. This study examines the relations among perceived employer support for creative work, different forms of underemployment and employee...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.12-0192-oa
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:Nickel oxide nanoparticles (NiONPs) are representative metal oxide NPs and are categorized as an insoluble nickel compound. Our previous studies suggested that NiONPs have more pulmonary toxicity than micron-sized NiO because they may dissolve slowly and produce many more Ni ions. We confirmed the hypothesis ...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1002/1348-9585.12162
更新日期:2020-01-01 00:00:00
abstract::Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) are synthetic surfactants used in Japan. An epidemiological study of workers exposed to PFOA revealed a significant increase in prostate cancer mortality. A cross-sectional study of PFOA-exposed workers showed that PFOA perturbs sex hormone homeostasis. We...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.46.49
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVES:The aims of the study were to investigate the systematic classification of subsidiary behaviors during visual display terminal (VDT) work and discuss the interpretation of these behaviors through an interactive model of subsidiary behaviors, work performance and autonomic nerve activity. METHODS:Twelve univ...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.l9110
更新日期:2010-01-01 00:00:00
abstract::Infrared Spectrophotometry (IR) is now widely used to determine crystalline silica in industrial dust samples. Though the IR method has many advantages when dealing with respirable dust samples, some serious analytical errors are often caused by interference minerals contamination. These minerals have a characteristic...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.45.94
更新日期:2003-03-01 00:00:00
abstract::Workplace violence, a possible cause of job stress, has recently become an important concern in occupational health. This study determined the prevalence of workplace violence and its risk factors for employees at a psychiatric hospital in Taiwan. A questionnaire developed by ILO/ICN/WHO/PSI was first translated and v...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.l7132
更新日期:2008-01-01 00:00:00
abstract::This study assessed the relationship of age, poor perception of working condition, poor safety environment, poor management and supervision, risk-taking behavior, emotional instability, negative job involvement, job dissatisfaction, job stress, and poor safety performance of workers to occupational injuries. This case...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.46.470
更新日期:2004-11-01 00:00:00
abstract:BACKGROUND:Healthcare workers are at high risk of infection from blood-borne pathogens, such as Hepatitis B and C Virus, and Human Immunodeficiency. Occupational exposure to needle-stick injuries (NSIs) continue to have a major health problem in the healthcare systems of developing countries. Thus, this review article ...
journal_title:Journal of occupational health
pub_type: 杂志文章,评审
doi:10.1002/1348-9585.12179
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:Work-related psychosocial hazards are associated with adverse health outcomes among workers. The association between psychosocial hazards and physiological health outcomes among laboratory technicians has not been studied previously. The objective of this study was to measure the association between work-rel...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.13-0050-fs
更新日期:2014-01-01 00:00:00
abstract::In Japan, consultations concerning child abuse cases are increasing rapidly, and the mental health of child-counseling office workers, who must deal with them, has emerged as an issue. To measure the state of mental health of these workers, and to clarify the characteristics of their job-related stress, we sent a ques...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.49.125
更新日期:2007-03-01 00:00:00
abstract:OBJECTIVES:The aim of this meta-analysis is to investigate to what extent vacation has positive effects on health and well-being, how long such effects endure after work resumption, and how specific vacation activities and experiences affect these relationships. METHODS:Based on a systematic literature search (PsycInf...
journal_title:Journal of occupational health
pub_type: 杂志文章,meta分析,评审
doi:10.1539/joh.k8004
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:To present the pitiable working conditions of clinical waste pickers in hospitals in the Northwest region of Cameroon and associated exposure to health hazards. METHODS:Observe clinical waste pickers as they carry out their functions for three days and carry out informal consultations (discussion) with the w...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.q9004
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVES:In this study, we focused on the qualitative and quantitative differences of the lung lesions induced by single or multiple intratracheal administration of nickel oxide nanoparticles (NiO). METHODS:Male rats were randomized into groups receiving intratracheal administrations in a single dose or two to four ...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.16-0184-OA
更新日期:2017-03-28 00:00:00
abstract:OBJECTIVES:Although well-being at work is important for occupational health, multi-dimensional workplace well-being measures do not exist for Japanese workers. The purpose of this study was to investigate the validity of the Japanese version of the Workplace PERMA-Profiler. METHODS:Japanese workers completed online su...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.2018-0050-OA
更新日期:2018-09-26 00:00:00
abstract:OBJECTIVES:The purpose of this study was to examine the effects of noise exposure on spatial learning and memory and associated mechanisms in the hippocampus (HIP). METHODS:Forty-eight male SD rats were grouped as: A, control; B, Morris water maze (MWM) training group; C, noise exposure group; and D, noise exposure fo...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.l8084
更新日期:2009-01-01 00:00:00
abstract::This paper investigates the effects of tanshin funin, a posting without family, on the health of married male workers. A prospective study using the pair-matched method was performed. One hundred and twenty-nine married male tanshin funin workers in their 40s and 50s and as many matched workers living with their famil...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.48.113
更新日期:2006-03-01 00:00:00
abstract::Although the main hazard in cement processing is dust and respiratory tract disorders are the most important group of occupational diseases in this industry, evidence for associations between exposure to cement dust and either respiratory symptoms or functional impairment has not been conclusive. This study was, there...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.49.273
更新日期:2007-07-01 00:00:00
abstract::The purpose of this study was to assess the value and usefulness of high resolution computed tomography (HRCT) in the diagnostics of small opacities and complications of silicosis in mine machinery manufacturing workers, compared to conventional radiograms. The diagnosis of silicosis is mainly based on the radiologica...
journal_title:Journal of occupational health
pub_type: 杂志文章,随机对照试验
doi:10.1539/joh.l8015
更新日期:2008-01-01 00:00:00
abstract::Systemic effects of p, p'-DDE (1, 1-dichloro-2, 2 bis (p-chlorophenyl) ethylene; DDE) on immature male rats were investigated in pubertal Wistar rats after oral administration of DDE. Special rat chow containing 125 ppm DDE (approximately 10 mg/kg DDE) had been administered daily for 42 d since 6 wk of age and its eff...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.45.223
更新日期:2003-07-01 00:00:00
abstract::The present study examined degrees of job-related stress factors as well as mental and physical symptoms among Japanese hospital nurses in various departments, and clarified associations of departments and job-related stress factors with those symptoms. A self-administered anonymous questionnaire was distributed to 1,...
journal_title:Journal of occupational health
pub_type: 杂志文章,多中心研究
doi:10.1539/joh.50.79
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVES:Along with technological innovations for improving the efficiency of printing, nanoparticles have been added to the surface of toners, and there is concern about the harmful effects of those components. We investigated, through a long-term observation following intratracheal instillation using rats, whether ...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1002/1348-9585.12146
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to investigate the effects of Nickel (Ni) -smelting fumes on oncogenic proteins in vivo and in vitro. METHODS:Ni fallout beside a Ni smelting furnace in a factory was sampled to study its toxic effect. The effects of Ni-smelting fumes on the regulation of PI3K and ERK signaling ...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.15-0287-OA
更新日期:2016-09-30 00:00:00
abstract::With the immense economic growth and social development, China has gained worldwide attention. With the quick growth of industrialization, several international professionals are gaining interest in occupational management system and in the role of the Chinese Government in protecting the worker's health. The Law on P...
journal_title:Journal of occupational health
pub_type: 杂志文章,评审
doi:10.1539/joh.17-0229-RA
更新日期:2018-03-27 00:00:00
abstract::This study prospectively examined the association between perceived noise exposure at work and cerebrovascular diseases among Japanese male workers. A baseline survey was conducted between 1988 and 1990, which involved 110,792 inhabitants (age range: 40-79 yr) from 45 areas throughout Japan. Subsequent causes of death...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.49.382
更新日期:2007-09-01 00:00:00
abstract::This Document, "Guidelines for personal exposure monitoring of chemicals" ("this Guideline"), has been prepared by "The Committee for Personal Exposure Monitoring" ("the Committee") of the Expert Division of Occupational Hygiene & Ergonomics, Japan Society for Occupational Health. Considering the background of the gro...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.17-0311-RA
更新日期:2018-03-27 00:00:00