Abstract:
:Chemokines were initially thought of only as regulators of the migration of developing thymocytes between different compartments of the thymus and were predicted also to be involved in early stages of thymocyte development. Recent data have suggested additional functions for the chemokine receptor CXCR4-a G protein-coupled receptor-in thymocyte development, particularly during the beta-selection developmental checkpoint. Phosphotidylinositol 3-kinase interacts with the pre-T cell receptor and CXCR4 during migration, proliferation, and differentiation of developing thymocytes. CXCR4 and Notch signaling, along with inhibition of glycogen synthase kinase-3beta (GSK-3beta), are essential for the proliferation and differentiation of thymocytes during beta-selection. Thus, a critical role of chemokines and its downstream signaling in the beta-selection of thymocytes has been demonstrated.
journal_name
Sci Signaljournal_title
Science signalingauthors
Ahamed JA,Madhivadhani Pdoi
10.1126/scisignal.3119jc4subject
Has Abstractpub_date
2010-04-27 00:00:00pages
jc4issue
119eissn
1945-0877issn
1937-9145pii
scisignal.3119jc4journal_volume
3pub_type
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