听力与言语-语言病理学

行为科学

医学伦理学

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  • Neuroligin-2 as a central organizer of inhibitory synapses in health and disease.

    abstract::Postsynaptic organizational protein complexes play central roles both in orchestrating synapse formation and in defining the functional properties of synaptic transmission that together shape the flow of information through neuronal networks. A key component of these organizational protein complexes is the family of s...

    journal_title:Science signaling

    pub_type: 杂志文章,评审

    doi:10.1126/scisignal.abd8379

    authors: Ali H,Marth L,Krueger-Burg D

    更新日期:2020-12-22 00:00:00

  • Aβ oligomers induce pathophysiological mGluR5 signaling in Alzheimer's disease model mice in a sex-selective manner.

    abstract::The prevalence, presentation, and progression of Alzheimer's disease (AD) differ between men and women, although β-amyloid (Aβ) deposition is a pathological hallmark of AD in both sexes. Aβ-induced activation of the neuronal glutamate receptor mGluR5 is linked to AD progression. However, we found that mGluR5 exhibits ...

    journal_title:Science signaling

    pub_type: 杂志文章

    doi:10.1126/scisignal.abd2494

    authors: Abd-Elrahman KS,Albaker A,de Souza JM,Ribeiro FM,Schlossmacher MG,Tiberi M,Hamilton A,Ferguson SSG

    更新日期:2020-12-15 00:00:00

  • Airway relaxation mechanisms and structural basis of osthole for improving lung function in asthma.

    abstract::Overuse of β2-adrenoceptor agonist bronchodilators evokes receptor desensitization, decreased efficacy, and an increased risk of death in asthma patients. Bronchodilators that do not target β2-adrenoceptors represent a critical unmet need for asthma management. Here, we characterize the utility of osthole, a coumarin ...

    journal_title:Science signaling

    pub_type: 杂志文章

    doi:10.1126/scisignal.aax0273

    authors: Wang S,Xie Y,Huo YW,Li Y,Abel PW,Jiang H,Zou X,Jiao HZ,Kuang X,Wolff DW,Huang YG,Casale TB,Panettieri RA Jr,Wei T,Cao Z,Tu Y

    更新日期:2020-11-24 00:00:00

  • Hug and hold tight: Dimerization controls the turnover of the ubiquitin-conjugating enzyme UBE2S.

    abstract::Precise control of the activity and abundance of ubiquitin-conjugating enzymes (E2s) ensures fidelity in ubiquitin chain synthesis. In this issue of Science Signaling, Liess et al. demonstrate that the human anaphase-promoting complex (APC/C)-associated E2 UBE2S adopts an autoinhibited dimeric state that increases the...

    journal_title:Science signaling

    pub_type: 杂志文章,评审

    doi:10.1126/scisignal.abd9892

    authors: Bremm A

    更新日期:2020-10-20 00:00:00

  • Quantitative kinase and phosphatase profiling reveal that CDK1 phosphorylates PP2Ac to promote mitotic entry.

    abstract::The reciprocal regulation of phosphoprotein phosphatases (PPPs) by protein kinases is essential to cell cycle progression and control, particularly during mitosis for which the role of kinases has been extensively studied. PPPs perform much of the serine/threonine dephosphorylation in eukaryotic cells and achieve subs...

    journal_title:Science signaling

    pub_type: 杂志文章

    doi:10.1126/scisignal.aba7823

    authors: Nasa I,Cressey LE,Kruse T,Hertz EPT,Gui J,Graves LM,Nilsson J,Kettenbach AN

    更新日期:2020-09-08 00:00:00

  • Bacterial invaders drive CRC progression.

    abstract::The oral bacterium Fusobacterium nucleatum is often found in colorectal cancer (CRC). In the 21 July 2020 issue of Science Signaling, Casasanta et al show that CRC cell-resident F. nucleatum promotes cytokine secretion that may potentiate tumor growth and metastatic progression in patients. ...

    journal_title:Science signaling

    pub_type: 杂志文章,评审

    doi:10.1126/scisignal.abc4218

    authors: Meyerson M

    更新日期:2020-08-11 00:00:00

  • Heterogeneity in human hippocampal CaMKII transcripts reveals allosteric hub-dependent regulation.

    abstract::Calcium/calmodulin-dependent protein kinase II (CaMKII) plays a central role in Ca2+ signaling throughout the body. In the hippocampus, CaMKII is required for learning and memory. Vertebrate genomes encode four CaMKII homologs: CaMKIIα, CaMKIIβ, CaMKIIγ, and CaMKIIδ. All CaMKIIs consist of a kinase domain, a regulator...

    journal_title:Science signaling

    pub_type: 杂志文章

    doi:10.1126/scisignal.aaz0240

    authors: Sloutsky R,Dziedzic N,Dunn MJ,Bates RM,Torres-Ocampo AP,Boopathy S,Page B,Weeks JG,Chao LH,Stratton MM

    更新日期:2020-07-21 00:00:00

  • TRPML1 channels initiate Ca2+ sparks in vascular smooth muscle cells.

    abstract::TRPML1 (transient receptor potential mucolipin 1) is a Ca2+-permeable, nonselective cation channel localized to the membranes of endosomes and lysosomes and is not present or functional on the plasma membrane. Ca2+ released from endosomes and lysosomes into the cytosol through TRPML1 channels is vital for trafficking,...

    journal_title:Science signaling

    pub_type: 杂志文章

    doi:10.1126/scisignal.aba1015

    authors: Thakore P,Pritchard HAT,Griffin CS,Yamasaki E,Drumm BT,Lane C,Sanders KM,Feng Earley Y,Earley S

    更新日期:2020-06-23 00:00:00

  • 4-1BB costimulation promotes CAR T cell survival through noncanonical NF-κB signaling.

    abstract::Clinical response to chimeric antigen receptor (CAR) T cell therapy is correlated with CAR T cell persistence, especially for CAR T cells that target CD19+ hematologic malignancies. 4-1BB-costimulated CAR (BBζ) T cells exhibit longer persistence after adoptive transfer than do CD28-costimulated CAR (28ζ) T cells. 4-1B...

    journal_title:Science signaling

    pub_type: 杂志文章

    doi:10.1126/scisignal.aay8248

    authors: Philipson BI,O'Connor RS,May MJ,June CH,Albelda SM,Milone MC

    更新日期:2020-03-31 00:00:00

  • SMAC mimetics and RIPK inhibitors as therapeutics for chronic inflammatory diseases.

    abstract::New therapeutic approaches for chronic inflammatory diseases such as inflammatory bowel disease, rheumatoid arthritis, and psoriasis are needed because current treatments are often suboptimal in terms of both efficacy and the risks of serious adverse events. Inhibitor of apoptosis proteins (IAPs) are E3 ubiquitin liga...

    journal_title:Science signaling

    pub_type: 杂志文章,评审

    doi:10.1126/scisignal.aax8295

    authors: Jensen S,Seidelin JB,LaCasse EC,Nielsen OH

    更新日期:2020-02-18 00:00:00

  • Probing the mutational landscape of regulators of G protein signaling proteins in cancer.

    abstract::The advent of deep-sequencing techniques has revealed that mutations in G protein-coupled receptor (GPCR) signaling pathways in cancer are more prominent than was previously appreciated. An emergent theme is that cancer-associated mutations tend to cause enhanced GPCR pathway activation to favor oncogenicity. Regulato...

    journal_title:Science signaling

    pub_type: 杂志文章

    doi:10.1126/scisignal.aax8620

    authors: DiGiacomo V,Maziarz M,Luebbers A,Norris JM,Laksono P,Garcia-Marcos M

    更新日期:2020-02-04 00:00:00

  • Acute O2 sensing through HIF2α-dependent expression of atypical cytochrome oxidase subunits in arterial chemoreceptors.

    abstract::Acute cardiorespiratory responses to O2 deficiency are essential for physiological homeostasis. The prototypical acute O2-sensing organ is the carotid body, which contains glomus cells expressing K+ channels whose inhibition by hypoxia leads to transmitter release and activation of nerve fibers terminating in the brai...

    journal_title:Science signaling

    pub_type: 杂志文章

    doi:10.1126/scisignal.aay9452

    authors: Moreno-Domínguez A,Ortega-Sáenz P,Gao L,Colinas O,García-Flores P,Bonilla-Henao V,Aragonés J,Hüttemann M,Grossman LI,Weissmann N,Sommer N,López-Barneo J

    更新日期:2020-01-21 00:00:00

  • Genetic diversity affects the nanoscale membrane organization and signaling of natural killer cell receptors.

    abstract::Genetic diversity in human natural killer (NK) cell receptors is linked to resistance and susceptibility to many diseases. Here, we tested the effect of this diversity on the nanoscale organization of killer cell immunoglobulin-like receptors (KIRs). Using superresolution microscopy, we found that inhibitory KIRs enco...

    journal_title:Science signaling

    pub_type: 杂志文章

    doi:10.1126/scisignal.aaw9252

    authors: Kennedy PR,Barthen C,Williamson DJ,Pitkeathly WTE,Hazime KS,Cumming J,Stacey KB,Hilton HG,Carrington M,Parham P,Davis DM

    更新日期:2019-12-17 00:00:00

  • Hypusine biosynthesis in β cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis.

    abstract::Deoxyhypusine synthase (DHPS) uses the polyamine spermidine to catalyze the hypusine modification of the mRNA translation factor eIF5A and promotes oncogenesis through poorly defined mechanisms. Because germline deletion of Dhps is embryonically lethal, its role in normal postnatal cellular function in vivo remains un...

    journal_title:Science signaling

    pub_type: 杂志文章

    doi:10.1126/scisignal.aax0715

    authors: Levasseur EM,Yamada K,Piñeros AR,Wu W,Syed F,Orr KS,Anderson-Baucum E,Mastracci TL,Maier B,Mosley AL,Liu Y,Bernal-Mizrachi E,Alonso LC,Scott D,Garcia-Ocaña A,Tersey SA,Mirmira RG

    更新日期:2019-12-03 00:00:00

  • Dynamic palmitoylation controls the microdomain localization of the DKK1 receptors CKAP4 and LRP6.

    abstract::Dickkopf1 (DKK1) was originally identified as an antagonist of Wnt signaling that binds to and induces the clathrin-mediated endocytosis of the Wnt coreceptors low-density lipoprotein receptor-related proteins 5 and 6 (LRP5/6). DKK1 also binds to cytoskeleton-associated protein 4 (CKAP4), which was originally identifi...

    journal_title:Science signaling

    pub_type: 杂志文章

    doi:10.1126/scisignal.aat9519

    authors: Sada R,Kimura H,Fukata Y,Fukata M,Yamamoto H,Kikuchi A

    更新日期:2019-11-19 00:00:00

  • Induction of metabolic quiescence defines the transitional to follicular B cell switch.

    abstract::Transitional B cells must actively undergo selection for self-tolerance before maturing into their resting follicular B cell successors. We found that metabolic quiescence was acquired at the follicular B cell stage in both humans and mice. In follicular B cells, the expression of genes involved in ribosome biogenesis...

    journal_title:Science signaling

    pub_type: 杂志文章

    doi:10.1126/scisignal.aaw5573

    authors: Farmer JR,Allard-Chamard H,Sun N,Ahmad M,Bertocchi A,Mahajan VS,Aicher T,Arnold J,Benson MD,Morningstar J,Barmettler S,Yuen G,Murphy SJH,Walter JE,Ghebremichael M,Shalek AK,Batista F,Gerszten R,Pillai S

    更新日期:2019-10-22 00:00:00

  • Tuning the regulator: Phosphorylation of KCC2 at two specific sites is critical for neurodevelopment.

    abstract::The K+/Cl- cotransporter KCC2 is a molecular switch between excitatory and inhibitory effects of GABAergic inputs into neurons. In a pair of exciting studies, Watanabe et al. and Pisella et al. elucidate the role of KCC2 dephosphorylation in this process and reveal its consequences for neurodevelopment and nervous sys...

    journal_title:Science signaling

    pub_type: 评论,杂志文章,评审

    doi:10.1126/scisignal.aay8960

    authors: Zamponi GW

    更新日期:2019-10-15 00:00:00

  • Full focus on calcium.

    abstract::Intracellular calcium (Ca2+) signals are of prime importance for cellular function and behavior and are underpinned by a plethora of Ca2+ channels, pumps, transporters, and binding proteins that are regulated in complex ways. A series of biennial meetings, the International Meetings of the European Calcium Society (EC...

    journal_title:Science signaling

    pub_type:

    doi:10.1126/scisignal.aaz0961

    authors: Parys JB,Guse AH

    更新日期:2019-09-17 00:00:00

  • mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β1-induced collagen biosynthesis.

    abstract::The differentiation of fibroblasts into a transient population of highly activated, extracellular matrix (ECM)-producing myofibroblasts at sites of tissue injury is critical for normal tissue repair. Excessive myofibroblast accumulation and persistence, often as a result of a failure to undergo apoptosis when tissue r...

    journal_title:Science signaling

    pub_type: 杂志文章

    doi:10.1126/scisignal.aav3048

    authors: Selvarajah B,Azuelos I,Platé M,Guillotin D,Forty EJ,Contento G,Woodcock HV,Redding M,Taylor A,Brunori G,Durrenberger PF,Ronzoni R,Blanchard AD,Mercer PF,Anastasiou D,Chambers RC

    更新日期:2019-05-21 00:00:00

  • Loss of MCU prevents mitochondrial fusion in G1-S phase and blocks cell cycle progression and proliferation.

    abstract::The role of the mitochondrial Ca2+ uniporter (MCU) in physiologic cell proliferation remains to be defined. Here, we demonstrated that the MCU was required to match mitochondrial function to metabolic demands during the cell cycle. During the G1-S transition (the cycle phase with the highest mitochondrial ATP output),...

    journal_title:Science signaling

    pub_type: 杂志文章

    doi:10.1126/scisignal.aav1439

    authors: Koval OM,Nguyen EK,Santhana V,Fidler TP,Sebag SC,Rasmussen TP,Mittauer DJ,Strack S,Goswami PC,Abel ED,Grumbach IM

    更新日期:2019-04-30 00:00:00

  • Differential regulation of Ca2+ influx by ORAI channels mediates enamel mineralization.

    abstract::Store-operated Ca2+ entry (SOCE) channels are highly selective Ca2+ channels activated by the endoplasmic reticulum (ER) sensors STIM1 and STIM2. Their direct interaction with the pore-forming plasma membrane ORAI proteins (ORAI1, ORAI2, and ORAI3) leads to sustained Ca2+ fluxes that are critical for many cellular fun...

    journal_title:Science signaling

    pub_type: 杂志文章

    doi:10.1126/scisignal.aav4663

    authors: Eckstein M,Vaeth M,Aulestia FJ,Costiniti V,Kassam SN,Bromage TG,Pedersen P,Issekutz T,Idaghdour Y,Moursi AM,Feske S,Lacruz RS

    更新日期:2019-04-23 00:00:00

  • Corticosteroid receptor balance regulates life and death in cardiomyocytes.

    abstract::Mineralocorticoid receptor (MR) antagonists are effective at treating heart failure. In this issue of Science Signaling, Oakley et al. provide new insight into their cardioprotective actions and highlight the importance of the opposing relationship between the MR and the related glucocorticoid receptor (GR) in the res...

    journal_title:Science signaling

    pub_type: 杂志文章,评审

    doi:10.1126/scisignal.aaw8715

    authors: Chapman KE

    更新日期:2019-04-16 00:00:00

  • Regulation of type I interferon: It's HIP to be K2.

    abstract::Uncontrolled expression of type I interferon (IFN-I) drives autoimmunity, necessitating the need for tight regulation. In this issue, Cao et al reveal a role for the kinase HIPK2 in the transcriptional control of IFN-I during antiviral immune responses. ...

    journal_title:Science signaling

    pub_type: 评论,杂志文章,评审

    doi:10.1126/scisignal.aaw8549

    authors: Best SM,Ponia SS

    更新日期:2019-03-19 00:00:00

  • Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein.

    abstract::The aggregation of α-synuclein (αSyn) is considered a key pathophysiological feature of certain neurodegenerative disorders, collectively termed synucleinopathies. Given that a prion-like, cell-to-cell transfer of misfolded αSyn has been recognized in the spreading of αSyn pathology in synucleinopathies, we investigat...

    journal_title:Science signaling

    pub_type: 杂志文章

    doi:10.1126/scisignal.aau4543

    authors: Harischandra DS,Rokad D,Neal ML,Ghaisas S,Manne S,Sarkar S,Panicker N,Zenitsky G,Jin H,Lewis M,Huang X,Anantharam V,Kanthasamy A,Kanthasamy AG

    更新日期:2019-03-12 00:00:00

  • Structure of the C-terminal guanine nucleotide exchange factor module of Trio in an autoinhibited conformation reveals its oncogenic potential.

    abstract::The C-terminal guanine nucleotide exchange factor (GEF) module of Trio (TrioC) transfers signals from the Gαq/11 subfamily of heterotrimeric G proteins to the small guanosine triphosphatase (GTPase) RhoA, enabling Gαq/11-coupled G protein-coupled receptors (GPCRs) to control downstream events, such as cell motility an...

    journal_title:Science signaling

    pub_type: 杂志文章

    doi:10.1126/scisignal.aav2449

    authors: Bandekar SJ,Arang N,Tully ES,Tang BA,Barton BL,Li S,Gutkind JS,Tesmer JJG

    更新日期:2019-02-19 00:00:00

  • Mechanisms of postsynaptic localization of AMPA-type glutamate receptors and their regulation during long-term potentiation.

    abstract::l-Glutamate is the main excitatory neurotransmitter in the brain, with postsynaptic responses to its release predominantly mediated by AMPA-type glutamate receptors (AMPARs). A critical component of synaptic plasticity involves changes in the number of responding postsynaptic receptors, which are dynamically recruited...

    journal_title:Science signaling

    pub_type: 杂志文章,评审

    doi:10.1126/scisignal.aar6889

    authors: Buonarati OR,Hammes EA,Watson JF,Greger IH,Hell JW

    更新日期:2019-01-01 00:00:00

  • FZD5 is a Gαq-coupled receptor that exhibits the functional hallmarks of prototypical GPCRs.

    abstract::Frizzleds (FZDs) are a group of seven transmembrane-spanning (7TM) receptors that belong to class F of the G protein-coupled receptor (GPCR) superfamily. FZDs bind WNT proteins to stimulate diverse signaling cascades involved in embryonic development, stem cell regulation, and adult tissue homeostasis. Frizzled 5 (FZD...

    journal_title:Science signaling

    pub_type: 杂志文章

    doi:10.1126/scisignal.aar5536

    authors: Wright SC,Cañizal MCA,Benkel T,Simon K,Le Gouill C,Matricon P,Namkung Y,Lukasheva V,König GM,Laporte SA,Carlsson J,Kostenis E,Bouvier M,Schulte G,Hoffmann C

    更新日期:2018-12-04 00:00:00

  • Aspirin ameliorates experimental autoimmune encephalomyelitis through interleukin-11-mediated protection of regulatory T cells.

    abstract::Multiple sclerosis (MS) is a human disease that results from autoimmune T cells targeting myelin protein that is expressed within the central nervous system. In MS, the number of FoxP3-expressing regulatory T cells (Tregs) is reduced, which facilitates the activation of autoreactive T cells. Because aspirin (acetylsal...

    journal_title:Science signaling

    pub_type: 杂志文章

    doi:10.1126/scisignal.aar8278

    authors: Mondal S,Jana M,Dasarathi S,Roy A,Pahan K

    更新日期:2018-11-27 00:00:00

  • The Src family kinase Fgr is a transforming oncoprotein that functions independently of SH3-SH2 domain regulation.

    abstract::Fgr is a member of the Src family of nonreceptor tyrosine kinases, which are overexpressed and constitutively active in many human cancers. Fgr expression is restricted to myeloid hematopoietic cells and is markedly increased in a subset of bone marrow samples from patients with acute myeloid leukemia (AML). Here, we ...

    journal_title:Science signaling

    pub_type: 杂志文章

    doi:10.1126/scisignal.aat5916

    authors: Shen K,Moroco JA,Patel RK,Shi H,Engen JR,Dorman HR,Smithgall TE

    更新日期:2018-10-23 00:00:00

  • Decreased abundance of TRESK two-pore domain potassium channels in sensory neurons underlies the pain associated with bone metastasis.

    abstract::Cancer-associated pain is debilitating. Understanding the mechanisms that cause it can inform drug development that may improve quality of life in patients. Here, we found that the reduced abundance of potassium channels called TRESK in dorsal root ganglion (DRG) neurons sensitized nociceptive sensory neurons and canc...

    journal_title:Science signaling

    pub_type: 杂志文章

    doi:10.1126/scisignal.aao5150

    authors: Yang Y,Li S,Jin ZR,Jing HB,Zhao HY,Liu BH,Liang YJ,Liu LY,Cai J,Wan Y,Xing GG

    更新日期:2018-10-16 00:00:00

  • Neratinib is effective in breast tumors bearing both amplification and mutation of ERBB2 (HER2).

    abstract::Mutations in ERBB2, the gene encoding epidermal growth factor receptor (EGFR) family member HER2, are common in and drive the growth of "HER2-negative" (not ERBB2 amplified) tumors but are rare in "HER2-positive" (ERBB2 amplified) breast cancer. We analyzed DNA-sequencing data from HER2-positive patients and used cell...

    journal_title:Science signaling

    pub_type: 杂志文章

    doi:10.1126/scisignal.aat9773

    authors: Cocco E,Javier Carmona F,Razavi P,Won HH,Cai Y,Rossi V,Chan C,Cownie J,Soong J,Toska E,Shifman SG,Sarotto I,Savas P,Wick MJ,Papadopoulos KP,Moriarty A,Cutler RE Jr,Avogadri-Connors F,Lalani AS,Bryce RP,Chandarlapa

    更新日期:2018-10-09 00:00:00

  • The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils.

    abstract::Neutrophil extracellular trap (NET) formation can generate short-term, functional anucleate cytoplasts and trigger loss of cell viability. We demonstrated that the necroptotic cell death effector mixed lineage kinase domain-like (MLKL) translocated from the cytoplasm to the plasma membrane and stimulated downstream NA...

    journal_title:Science signaling

    pub_type: 杂志文章

    doi:10.1126/scisignal.aao1716

    authors: D'Cruz AA,Speir M,Bliss-Moreau M,Dietrich S,Wang S,Chen AA,Gavillet M,Al-Obeidi A,Lawlor KE,Vince JE,Kelliher MA,Hakem R,Pasparakis M,Williams DA,Ericsson M,Croker BA

    更新日期:2018-09-04 00:00:00

  • TGF-β-mediated enhancement of TH17 cell generation is inhibited by bone morphogenetic protein receptor 1α signaling.

    abstract::The cytokines of the transforming growth factor-β (TGF-β) family promote the growth and differentiation of multiple tissues, but the role of only the founding member, TGF-β, in regulating the immune responses has been extensively studied. TGF-β is critical to prevent the spontaneous activation of self-reactive T cells...

    journal_title:Science signaling

    pub_type: 杂志文章

    doi:10.1126/scisignal.aar2125

    authors: Browning LM,Pietrzak M,Kuczma M,Simms CP,Kurczewska A,Refugia JM,Lowery DJ,Rempala G,Gutkin D,Ignatowicz L,Muranski P,Kraj P

    更新日期:2018-08-28 00:00:00

  • Phosphoproteomic analysis of chimeric antigen receptor signaling reveals kinetic and quantitative differences that affect cell function.

    abstract::Chimeric antigen receptors (CARs) link an antigen recognition domain to intracellular signaling domains to redirect T cell specificity and function. T cells expressing CARs with CD28/CD3ζ or 4-1BB/CD3ζ signaling domains are effective at treating refractory B cell malignancies but exhibit differences in effector functi...

    journal_title:Science signaling

    pub_type: 杂志文章

    doi:10.1126/scisignal.aat6753

    authors: Salter AI,Ivey RG,Kennedy JJ,Voillet V,Rajan A,Alderman EJ,Voytovich UJ,Lin C,Sommermeyer D,Liu L,Whiteaker JR,Gottardo R,Paulovich AG,Riddell SR

    更新日期:2018-08-21 00:00:00

  • Quantitative analysis of competitive cytokine signaling predicts tissue thresholds for the propagation of macrophage activation.

    abstract::Toll-like receptor (TLR) signaling regulates macrophage activation and effector cytokine propagation in the constrained environment of a tissue. In macrophage populations, TLR4 stimulates the dose-dependent transcription of nuclear factor κB (NF-κB) target genes. However, using single-RNA counting, we found that indiv...

    journal_title:Science signaling

    pub_type: 杂志文章

    doi:10.1126/scisignal.aaf3998

    authors: Bagnall J,Boddington C,England H,Brignall R,Downton P,Alsoufi Z,Boyd J,Rowe W,Bennett A,Walker C,Adamson A,Patel NMX,O'Cualain R,Schmidt L,Spiller DG,Jackson DA,Müller W,Muldoon M,White MRH,Paszek P

    更新日期:2018-07-24 00:00:00

  • The costimulatory molecule CD226 signals through VAV1 to amplify TCR signals and promote IL-17 production by CD4+ T cells.

    abstract::The activation of T cells requires the guanine nucleotide exchange factor VAV1. Using mice in which a tag for affinity purification was attached to endogenous VAV1 molecules, we analyzed by quantitative mass spectrometry the signaling complex that assembles around activated VAV1. Fifty VAV1-binding partners were ident...

    journal_title:Science signaling

    pub_type: 杂志文章

    doi:10.1126/scisignal.aar3083

    authors: Gaud G,Roncagalli R,Chaoui K,Bernard I,Familiades J,Colacios C,Kassem S,Monsarrat B,Burlet-Schiltz O,de Peredo AG,Malissen B,Saoudi A

    更新日期:2018-07-10 00:00:00

  • Evolution of human, chicken, alligator, frog, and zebrafish mineralocorticoid receptors: Allosteric influence on steroid specificity.

    abstract::Although multiple steroid ligands of the glucocorticoid, mineralocorticoid, and progestin families bind to and regulate the activity of mineralocorticoid receptors (MRs), the responses to these ligands differ across species. To understand how the different domains of MRs contribute to the ligand-induced activation or ...

    journal_title:Science signaling

    pub_type: 杂志文章

    doi:10.1126/scisignal.aao1520

    authors: Katsu Y,Oka K,Baker ME

    更新日期:2018-07-03 00:00:00

  • Lgl reduces endosomal vesicle acidification and Notch signaling by promoting the interaction between Vap33 and the V-ATPase complex.

    abstract::Epithelial cell polarity is linked to the control of tissue growth and tumorigenesis. The tumor suppressor and cell polarity protein lethal-2-giant larvae (Lgl) promotes Hippo signaling and inhibits Notch signaling to restrict tissue growth in Drosophila melanogaster Notch signaling is greater in lgl mutant tissue tha...

    journal_title:Science signaling

    pub_type: 杂志文章

    doi:10.1126/scisignal.aar1976

    authors: Portela M,Yang L,Paul S,Li X,Veraksa A,Parsons LM,Richardson HE

    更新日期:2018-06-05 00:00:00

  • IRE1α prevents hepatic steatosis by processing and promoting the degradation of select microRNAs.

    abstract::Obesity or a high-fat diet represses the endoribonuclease activity of inositol-requiring enzyme 1α (IRE1α), a transducer of the unfolded protein response (UPR) in cells under endoplasmic reticulum (ER) stress. An impaired UPR is associated with hepatic steatosis and nonalcoholic fatty liver disease (NAFLD), which is c...

    journal_title:Science signaling

    pub_type: 杂志文章

    doi:10.1126/scisignal.aao4617

    authors: Wang JM,Qiu Y,Yang Z,Kim H,Qian Q,Sun Q,Zhang C,Yin L,Fang D,Back SH,Kaufman RJ,Yang L,Zhang K

    更新日期:2018-05-15 00:00:00

  • CCR5 adopts three homodimeric conformations that control cell surface delivery.

    abstract::Biophysical methods and x-ray crystallography have revealed that class A G protein-coupled receptors (GPCRs) can form homodimers. We combined computational approaches with receptor cross-linking, energy transfer, and a newly developed functional export assay to characterize the residues involved in the dimerization in...

    journal_title:Science signaling

    pub_type: 杂志文章

    doi:10.1126/scisignal.aal2869

    authors: Jin J,Momboisse F,Boncompain G,Koensgen F,Zhou Z,Cordeiro N,Arenzana-Seisdedos F,Perez F,Lagane B,Kellenberger E,Brelot A

    更新日期:2018-05-08 00:00:00

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