Abstract:
:Regulatory T (T(reg)) cells are a unique CD4(+) T cell lineage that plays a crucial role in the maintenance of immunological tolerance. The Forkhead box transcription factor Foxp3 is critically involved in T(reg) cell development and responsible for determining the suppressive function of these cells. The majority of Foxp3(+) T(reg) cells are generated during T cell development within the thymus and show features of a stable T cell lineage. New work indicates that both induction and stabilization of Foxp3 expression are under epigenetic control, which suggests that selective interference with the underlying chromatin remodeling mechanisms might enable the development of future therapeutic strategies targeting T(reg) cells.
journal_name
Sci Signaljournal_title
Science signalingauthors
Toker A,Huehn Jdoi
10.1126/scisignal.2001783subject
Has Abstractpub_date
2011-02-01 00:00:00pages
pe4issue
158eissn
1945-0877issn
1937-9145pii
scisignal.2001783journal_volume
4pub_type
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