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HIF takes it up a notch.

Abstract：

:Notch signaling is used to choose cell fates in many developmental contexts. New evidence shows that circulating blood cells in Drosophila, in the absence of Notch ligand provided by neighboring cells, activate Notch signaling through stabilization with the hypoxia-inducible factor-α (HIF-α) transcription factor. Although HIF-α is a key regulator of the low-oxygen stress response, here it acts without its HIF-β partner by interacting with and stabilizing the Notch receptor. These roles for HIF-α and Notch are atypical in multiple ways, from the activity of HIF-α under normal oxygen tensions and without its partner HIF-β to the ligand-independent activity of Notch, and serve as a challenge to identify other noncanonical uses of well-studied signaling pathways.

journal_name

Sci Signal

journal_title

Science signaling

authors

Johnson EA

doi

10.1126/scisignal.2002277

subject

Has Abstract

pub_date

2011-07-12 00:00:00

pages

pe33

issue

181

eissn

1945-0877

issn

1937-9145

pii

scisignal.2002277

journal_volume

4

pub_type

杂志文章,评审

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