Abstract:
:The hypoxia inducible factors (HIFs) and CCAAT/enhancer binding protein alpha (C/EBP alpha) are transcription factors that mediate adaptive responses to hypoxia and control aspects of energy metabolism, respectively. New evidence suggests that when HIF-1 alpha and C/EBP alpha interact, they bring about reciprocal functional changes, so that the activity of HIF-1 alpha is decreased and that of C/EBP alpha is restricted or increased in a tissue-specific manner. This Journal Club article highlights research depicting interactions between HIF-1 alpha and C/EBP alpha and discusses conditions and tissues in which this interaction might occur.
journal_name
Sci Signaljournal_title
Science signalingauthors
Janardhan HPdoi
10.1126/scisignal.143jc2subject
Has Abstractpub_date
2008-10-28 00:00:00pages
jc2issue
43eissn
1945-0877issn
1937-9145pii
scisignal.143jc2journal_volume
1pub_type
杂志文章,评审abstract::Chimeric antigen receptors (CARs) link an antigen recognition domain to intracellular signaling domains to redirect T cell specificity and function. T cells expressing CARs with CD28/CD3ζ or 4-1BB/CD3ζ signaling domains are effective at treating refractory B cell malignancies but exhibit differences in effector functi...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aat6753
更新日期:2018-08-21 00:00:00
abstract::Double knockout of PTEN and LKB1-genes encoding phosphatase and tensin homolog and liver kinase B1, respectively-leads to the spontaneous development of cancer in mice. PTEN converts phosphatidylinositol (3,4,5)-trisphosphate (PIP3) to phosphatidylinositol (4,5)-bisphosphate (PIP2), whereas LKB1 activates the 5' adeno...
journal_title:Science signaling
pub_type: 杂志文章,评审
doi:10.1126/scisignal.aac8321
更新日期:2015-09-01 00:00:00
abstract::Cerebral amyloid angiopathy (CAA) is a vascular dysfunction disorder characterized by deposits of amyloid-β (Aβ) in the walls of cerebral vessels. CAA and Aβ deposition in the brain parenchyma contribute to dementia and Alzheimer's disease (AD). We investigated the contribution of platelets, which accumulate at vascul...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aaf6240
更新日期:2016-05-24 00:00:00
abstract::Hedgehog (Hh) signaling plays varied and critical roles in animal development, homeostasis, and disease. The core components of the canonical pathway and many key modulators of signaling have been identified, as have mechanisms by which the quantity and quality of signaling through the pathway are modulated. New resea...
journal_title:Science signaling
pub_type: 社论
doi:10.1126/scisignal.2002653
更新日期:2011-11-22 00:00:00
abstract::Ovarian cancer is a complex disease with heterogeneity among the gene expression molecular subtypes (GEMS) between patients. Patients with tumors of a mesenchymal ("Mes") subtype have a poorer prognosis than patients with tumors of an epithelial ("Epi") subtype. We evaluated GEMS of ovarian cancer patients for molecul...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aaf8175
更新日期:2016-10-04 00:00:00
abstract::In lymphocytes, the kinase Mst1 is required for the proper organization of integrins in the plasma membrane at the leading edge of migrating cells, which is critical for lymphocyte trafficking. We found a functional link between the small G protein Rab13 and Mst1 in lymphocyte adhesion and migration. In response to st...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2005199
更新日期:2014-07-29 00:00:00
abstract::The accumulation of damaged or excess proteins and organelles is a defining feature of metabolic disease in nearly every tissue. Thus, a central challenge in maintaining metabolic homeostasis is the identification, sequestration, and degradation of these cellular components, including protein aggregates, mitochondria,...
journal_title:Science signaling
pub_type: 杂志文章,评审
doi:10.1126/scisignal.aag2298
更新日期:2017-02-28 00:00:00
abstract::Deoxyhypusine synthase (DHPS) uses the polyamine spermidine to catalyze the hypusine modification of the mRNA translation factor eIF5A and promotes oncogenesis through poorly defined mechanisms. Because germline deletion of Dhps is embryonically lethal, its role in normal postnatal cellular function in vivo remains un...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aax0715
更新日期:2019-12-03 00:00:00
abstract::Premature labor and consequent neonatal mortality may be prevented by stimulating the expression of PIBF1 in uterine B cells. ...
journal_title:Science signaling
pub_type: 评论,杂志文章
doi:10.1126/scisignal.aam7592
更新日期:2017-01-17 00:00:00
abstract::T helper (T(H)) cells integrate biochemical cues present in the tissue microenvironment and produce cytokines that orchestrate immune responses. Previous discoveries have revealed a qualitative understanding of how T(H) cells process this biochemical information; however, the lack of methods to quantify how well these...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2002657
更新日期:2012-04-17 00:00:00
abstract::Frizzleds (FZDs) are a group of seven transmembrane-spanning (7TM) receptors that belong to class F of the G protein-coupled receptor (GPCR) superfamily. FZDs bind WNT proteins to stimulate diverse signaling cascades involved in embryonic development, stem cell regulation, and adult tissue homeostasis. Frizzled 5 (FZD...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aar5536
更新日期:2018-12-04 00:00:00
abstract::Extracellular hyperosmolarity, or osmotic stress, generally caused by differences in salt and macromolecule concentrations across the plasma membrane, occurs in lymphoid organs and at inflammatory sites. The response of immune cells to osmotic stress is regulated by nuclear factor of activated T cells 5 (NFAT5), a tra...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2000081
更新日期:2009-02-10 00:00:00
abstract::The guanosine triphosphatases of the Rho and Rac subfamilies regulate protumorigenic pathways and are activated by guanine nucleotide exchange factors (Rho GEFs), which could be potential targets for anticancer therapies. We report that two Rho GEFs, Vav2 and Vav3, play synergistic roles in breast cancer by sustaining...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2002962
更新日期:2012-10-02 00:00:00
abstract::Adenosine 5'-diphosphate (ADP)-ribosylation is a protein posttranslational modification that is catalyzed by ADP-ribosyltransferases (ARTs), using nicotinamide adenine dinucleotide (NAD(+)) as a substrate. Mono-ribosylation can be extended into polymers of ADP-ribose (PAR). Poly(ADP-ribosyl)polymerase (PARP) 1, the be...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2001645
更新日期:2011-05-24 00:00:00
abstract::Spontaneous neural differentiation of embryonic stem cells is induced by Noggin-mediated inhibition of bone morphogenetic protein 4 (BMP4) signaling. RhoA is a guanosine triphosphatase (GTPase) that regulates cytoskeletal dynamics and gene expression, both of which control stem cell fate. We found that disruption of S...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aaf0791
更新日期:2016-07-26 00:00:00
abstract::Transforming growth factor-β (TGF-β) is a pluripotent cytokine that regulates cell fate and plasticity in normal tissues and tumors. The multifunctional cellular responses evoked by TGF-β are mediated by the canonical SMAD pathway and by noncanonical pathways, including mitogen-activated protein kinase (MAPK) pathways...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aal4186
更新日期:2017-07-04 00:00:00
abstract::The mechanisms of context-specific differences in signal transduction, such as those that occur among different cell types, are not fully understood. One possibility is that differences in the abundance of proteins change signaling outputs because these proteins compete for binding to hub proteins at critical network ...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2004560
更新日期:2013-12-17 00:00:00
abstract::Staphylococcus aureus is an important opportunistic human pathogen that is highly resistant to osmotic stresses. To survive an increase in osmolarity, bacteria immediately take up potassium ions and small organic compounds known as compatible solutes. The second messenger cyclic diadenosine monophosphate (c-di-AMP) re...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aaf7279
更新日期:2016-08-16 00:00:00
abstract::In a mouse model of Parkinson's disease, new evidence shows that l-DOPA, which is used to treat the symptoms of the disease but also causes dyskinesia, results in a persistent activation of the protein kinase mTOR (mammalian target of rapamycin) in a subset of striatal medium spiny neurons. Moreover, blockade of a spe...
journal_title:Science signaling
pub_type: 杂志文章,评审
doi:10.1126/scisignal.280pe42
更新日期:2009-07-21 00:00:00
abstract::This year's signaling breakthroughs highlight insights into the pathogenesis or treatment of cancer, malaria, and neurodegenerative disorders; reveal molecular insights into cell death; and identify signals that could be leveraged to prevent plant parasitism or engineer bacteria as microbial fuel cells. ...
journal_title:Science signaling
pub_type: 社论
doi:10.1126/scisignal.aad9795
更新日期:2016-01-05 00:00:00
abstract::Cytosolic pattern recognition receptors (PRRs) sense intracellular nucleic acids from pathogens such as bacteria and viruses, which leads to the induction of type I interferon (IFN) responses that are essential for an effective immune response. Further, these PRR pathways can be aberrantly activated by self DNA, which...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2002919
更新日期:2012-03-06 00:00:00
abstract::The deubiquitylating enzyme OTUB1 is present in all tissues and targets many substrates, in both the cytosol and nucleus. We found that casein kinase 2 (CK2) phosphorylated OTUB1 at Ser(16) to promote its nuclear accumulation in cells. Pharmacological inhibition or genetic ablation of CK2 blocked the phosphorylation o...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aaa0441
更新日期:2015-04-14 00:00:00
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journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aaf9558
更新日期:2016-09-20 00:00:00
abstract::Over the last 50 years, the posttranslational modification (PTM) of proteins has emerged as a central mechanism for cells to regulate metabolism, growth, differentiation, cell-cell interactions, and immune responses. By influencing protein structure and function, PTM leads to a multiplication of proteome diversity. Re...
journal_title:Science signaling
pub_type: 杂志文章,评审
doi:10.1126/scisignal.290re7
更新日期:2009-09-29 00:00:00
abstract::The V600E mutation in the kinase BRAF is frequently detected in melanomas and results in constitutive activation of BRAF, which then promotes cell proliferation by the mitogen-activated protein kinase signaling pathway. Although the BRAFV600E kinase inhibitor vemurafenib has remarkable antitumor activity in patients w...
journal_title:Science signaling
pub_type: 临床试验,杂志文章
doi:10.1126/scisignal.2003057
更新日期:2013-01-29 00:00:00
abstract::Acute cardiorespiratory responses to O2 deficiency are essential for physiological homeostasis. The prototypical acute O2-sensing organ is the carotid body, which contains glomus cells expressing K+ channels whose inhibition by hypoxia leads to transmitter release and activation of nerve fibers terminating in the brai...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aay9452
更新日期:2020-01-21 00:00:00
abstract::The fluorescent properties of the amino acid tryptophan make it a useful tool for fluorometric assays. Because tryptophan fluorescence is remarkably sensitive to the polarity of the environment, it can be used to determine the affinity of tryptophan-containing peptides for phospholipid vesicles of varying compositions...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.299pl4
更新日期:2009-12-01 00:00:00
abstract::The diacylglycerol kinases (DGKs) attenuate diacylglycerol (DAG)-mediated signals by catalyzing the conversion of DAG to phosphatidic acid. In T lymphocytes, the antigen-stimulated generation of DAG links signal strength to the intensity and duration of signaling by the Ras-extracellular signal-regulated kinase (ERK) ...
journal_title:Science signaling
pub_type: 杂志文章,评审
doi:10.1126/scisignal.aaa0974
更新日期:2015-04-28 00:00:00
abstract::The extracellular Ca(2+)-sensing receptor (CaSR) plays a nonredundant role in the functions of the parathyroid gland (PTG) and the kidney. Severe hyperparathyroidism, premature death, and incomplete gene excision in Casr(-/-) mice have precluded the assessment of CaSR function in other tissues. We generated mice with ...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.1159945
更新日期:2008-09-02 00:00:00
abstract::The CLAVATA (CLV) and flagellin (flg) signaling pathways act through peptide ligands and closely related plasma membrane-localized receptor-like kinases (RLKs). The plant peptide CLV3 regulates stem cell homeostasis, whereas the bacterial flg22 peptide elicits defense responses. We applied multiparameter fluorescence ...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aab0598
更新日期:2015-08-04 00:00:00