Abstract:
:This year's signaling breakthroughs highlight insights into the pathogenesis or treatment of cancer, malaria, and neurodegenerative disorders; reveal molecular insights into cell death; and identify signals that could be leveraged to prevent plant parasitism or engineer bacteria as microbial fuel cells.
journal_name
Sci Signaljournal_title
Science signalingauthors
Adler EMdoi
10.1126/scisignal.aad9795subject
Has Abstractpub_date
2016-01-05 00:00:00pages
eg1issue
409eissn
1945-0877issn
1937-9145pii
9/409/eg1journal_volume
9pub_type
社论abstract::Type I interferons (IFNs), including various IFN-α isoforms and IFN-β, are a family of homologous, multifunctional cytokines. IFNs activate different cellular responses by binding to a common receptor that consists of two subunits, IFNAR1 and IFNAR2. In addition to stimulating antiviral responses, they also inhibit ce...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2004998
更新日期:2014-05-27 00:00:00
abstract::Activation of vascular endothelial growth factor (VEGF) receptor 2 (VEGFR2) by VEGF binding is critical for vascular morphogenesis. In addition, VEGF disrupts the endothelial barrier by triggering the phosphorylation and turnover of the junctional molecule VE-cadherin, a process mediated by the VEGFR2 downstream effec...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aad9256
更新日期:2016-07-19 00:00:00
abstract::Secreted IgD concentration depends on the presence of microbiota. ...
journal_title:Science signaling
pub_type: 评论,杂志文章,评审
doi:10.1126/scisignal.aan0005
更新日期:2017-02-21 00:00:00
abstract::Neutrophil extracellular trap (NET) formation can generate short-term, functional anucleate cytoplasts and trigger loss of cell viability. We demonstrated that the necroptotic cell death effector mixed lineage kinase domain-like (MLKL) translocated from the cytoplasm to the plasma membrane and stimulated downstream NA...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aao1716
更新日期:2018-09-04 00:00:00
abstract::Plants and animals produce reactive oxygen species (ROS) in response to infection. In plants, ROS not only activate defense responses and promote cell death to limit the spread of pathogens but also restrict the amount of cell death in response to pathogen recognition. Plants also use hormones, such as salicylic acid,...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2004777
更新日期:2014-04-08 00:00:00
abstract::Vascular endothelial growth factors (VEGFs) regulate blood and lymphatic vessel development through VEGF receptors (VEGFRs). The VEGFR immunoglobulin homology domain 2 (D2) is critical for ligand binding, and D3 provides additional interaction sites. VEGF-B and placenta growth factor (PlGF) bind to VEGFR-1 with high a...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2003905
更新日期:2013-07-02 00:00:00
abstract::The C-terminal guanine nucleotide exchange factor (GEF) module of Trio (TrioC) transfers signals from the Gαq/11 subfamily of heterotrimeric G proteins to the small guanosine triphosphatase (GTPase) RhoA, enabling Gαq/11-coupled G protein-coupled receptors (GPCRs) to control downstream events, such as cell motility an...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aav2449
更新日期:2019-02-19 00:00:00
abstract::One reported function of the tumor suppressor p19(Arf) is to stabilize p53, providing a critical checkpoint in the response to oncogenic insults. Acute loss of Pten leads to an increase in the abundance of p19(Arf), p53, and p21 proteins as part of a fail-safe senescence response. Here, we report that loss of p19(Arf)...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2000053
更新日期:2009-08-18 00:00:00
abstract::Transitional B cells must actively undergo selection for self-tolerance before maturing into their resting follicular B cell successors. We found that metabolic quiescence was acquired at the follicular B cell stage in both humans and mice. In follicular B cells, the expression of genes involved in ribosome biogenesis...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aaw5573
更新日期:2019-10-22 00:00:00
abstract::Cancer-associated pain is debilitating. Understanding the mechanisms that cause it can inform drug development that may improve quality of life in patients. Here, we found that the reduced abundance of potassium channels called TRESK in dorsal root ganglion (DRG) neurons sensitized nociceptive sensory neurons and canc...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aao5150
更新日期:2018-10-16 00:00:00
abstract::The symbiotic interaction between Rhizobium bacteria and legume plants leads to the induction of a new developmental program: the formation of nitrogen-fixing root nodules. Nodulation is triggered by specific bacterial signals, the Nod factors, and integrates plant developmental regulatory pathways to reactivate diffe...
journal_title:Science signaling
pub_type: 杂志文章,评审
doi:10.1126/scisignal.149re11
更新日期:2008-12-09 00:00:00
abstract::Cerebral amyloid angiopathy (CAA) is a vascular dysfunction disorder characterized by deposits of amyloid-β (Aβ) in the walls of cerebral vessels. CAA and Aβ deposition in the brain parenchyma contribute to dementia and Alzheimer's disease (AD). We investigated the contribution of platelets, which accumulate at vascul...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aaf6240
更新日期:2016-05-24 00:00:00
abstract::The LKB1 serine-threonine kinase is a tumor suppressor that is inactivated in a large number of sporadic human lung non-small cell carcinomas (NSCLCs) and cervical cancers. Genetic deletion of LKB1 in various mouse tissues results in tumorigenesis, and loss of LKB1 increases metastasis in a mouse model of NSCLC. LKB1 ...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.286pe55
更新日期:2009-09-01 00:00:00
abstract::The role of mucin 1 (MUC1) in protecting epithelia from microbial infection, enzymatic digestion, and other irritants has been appreciated for some time. In addition, MUC1 serves as a barrier to embryo implantation. MUC1 is highly abundant in many tumors in which its role in barrier function may serve to protect cells...
journal_title:Science signaling
pub_type: 杂志文章,评审
doi:10.1126/scisignal.127pe35
更新日期:2008-07-08 00:00:00
abstract::Toll-like receptor (TLR) signaling regulates macrophage activation and effector cytokine propagation in the constrained environment of a tissue. In macrophage populations, TLR4 stimulates the dose-dependent transcription of nuclear factor κB (NF-κB) target genes. However, using single-RNA counting, we found that indiv...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aaf3998
更新日期:2018-07-24 00:00:00
abstract::Parkinson's disease (PD) is a neurodegenerative disorder in which the loss of dopaminergic neurons in the midbrain (mDA neurons) causes progressive loss of motor control and function. Using embryonic and mDA neurons, midbrain tissue from mice, and differentiated human neural stem cells, we investigated the mechanisms ...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aal4165
更新日期:2017-08-22 00:00:00
abstract::A central component of receptor-evoked Ca(2+) signaling is store-operated Ca(2+) entry (SOCE), which is activated by the assembly of STIM1-Orai1 channels in endoplasmic reticulum (ER) and plasma membrane (PM) (ER-PM) junctions in response to depletion of ER Ca(2+). We report that STIM2 enhances agonist-mediated activa...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2005748
更新日期:2015-01-13 00:00:00
abstract::The hypoxia inducible factors (HIFs) and CCAAT/enhancer binding protein alpha (C/EBP alpha) are transcription factors that mediate adaptive responses to hypoxia and control aspects of energy metabolism, respectively. New evidence suggests that when HIF-1 alpha and C/EBP alpha interact, they bring about reciprocal func...
journal_title:Science signaling
pub_type: 杂志文章,评审
doi:10.1126/scisignal.143jc2
更新日期:2008-10-28 00:00:00
abstract::Staphylococcus aureus is an important opportunistic human pathogen that is highly resistant to osmotic stresses. To survive an increase in osmolarity, bacteria immediately take up potassium ions and small organic compounds known as compatible solutes. The second messenger cyclic diadenosine monophosphate (c-di-AMP) re...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aaf7279
更新日期:2016-08-16 00:00:00
abstract::This two-issue series focuses on how understanding how signaling pathways are altered in cancer cells can enable researchers to develop more effective therapies. Cancer is a pleiotropic disease. Tumor cells change over time and, even within a specific tumor, cells may have different mutations and dependencies on diffe...
journal_title:Science signaling
pub_type: 社论
doi:10.1126/scisignal.2004149
更新日期:2013-03-26 00:00:00
abstract::The proteasome plays a pivotal role in the cellular response to oxidative stress. Here, we used biochemical and mass spectrometric methods to investigate structural changes in the 26S proteasomes from yeast and mammalian cells exposed to hydrogen peroxide (H₂O₂). Oxidative stress induced the dissociation of the 20S co...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2001232
更新日期:2010-12-07 00:00:00
abstract::In Drosophila, recognition of microbe-specific molecules (such as bacterial peptidoglycans) activates serine protease cascades that converge to activate the Toll pathway. Recent data show that the serine protease Grass, which is activated downstream of pattern recognition receptors and was initially thought to be a co...
journal_title:Science signaling
pub_type: 杂志文章,评审
doi:10.1126/scisignal.252jc1
更新日期:2009-01-06 00:00:00
abstract::Precise regulation of nuclear factor κB (NF-κB) signaling is crucial for normal immune responses, and defective NF-κB activity underlies a range of immunodeficiencies. NF-κB is activated through two signaling cascades: the classical and noncanonical pathways. The classical pathway requires inhibitor of κB kinase β (IK...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2004557
更新日期:2014-02-04 00:00:00
abstract::Jasmonates control defense gene expression, growth, and fertility throughout the plant kingdom and have been studied extensively in Arabidopsis thaliana. The prohormone jasmonic acid (JA) is conjugated to amino acids such as isoleucine to form the active hormone jasmonoyl-isoleucine (JA-Ile). A series of breakthroughs...
journal_title:Science signaling
pub_type: 杂志文章,评审
doi:10.1126/scisignal.3109cm4
更新日期:2010-02-16 00:00:00
abstract::The role of the mitochondrial Ca2+ uniporter (MCU) in physiologic cell proliferation remains to be defined. Here, we demonstrated that the MCU was required to match mitochondrial function to metabolic demands during the cell cycle. During the G1-S transition (the cycle phase with the highest mitochondrial ATP output),...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aav1439
更新日期:2019-04-30 00:00:00
abstract::The mechanisms that determine localized formation of reactive oxygen species (ROS) through NADPH (reduced form of nicotinamide adenine dinucleotide phosphate) oxidase (Nox) family members in nonphagocytic cells are unknown. We show that the c-Src substrate proteins Tks4 (tyrosine kinase substrate with four SH3 domains...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2000370
更新日期:2009-09-15 00:00:00
abstract::The V600E mutation in the kinase BRAF is frequently detected in melanomas and results in constitutive activation of BRAF, which then promotes cell proliferation by the mitogen-activated protein kinase signaling pathway. Although the BRAFV600E kinase inhibitor vemurafenib has remarkable antitumor activity in patients w...
journal_title:Science signaling
pub_type: 临床试验,杂志文章
doi:10.1126/scisignal.2003057
更新日期:2013-01-29 00:00:00
abstract::Morphogens form concentration gradients that organize patterns of cells and control growth. It has been suggested that, rather than the intensity of morphogen signaling, it is its gradation that is the relevant modulator of cell proliferation. According to this view, the ability of morphogens to regulate growth during...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2000360
更新日期:2009-10-06 00:00:00
abstract::The prevailing view has been that N-terminally truncated p53 family isoforms (ΔNp53, ΔNp63, and DNp73) predominantly counteract cell cycle arrest and apoptosis. Recent progress in the field extend these well-known functions and place these isoforms in the center of a comprehensive regulatory network controlling major ...
journal_title:Science signaling
pub_type: 杂志文章,评审
doi:10.1126/scisignal.2005699
更新日期:2014-09-30 00:00:00
abstract::Netrin-1 displays proto-oncogenic activity in several cancers, which is thought to be due to the ability of this secreted cue to stimulate survival when bound to its receptors. We showed that in contrast to full-length, secreted netrin-1, some cancer cells produced a truncated intranuclear form of netrin-1 (ΔN-netrin-...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2002456
更新日期:2012-08-07 00:00:00