Abstract:
:In Drosophila, recognition of microbe-specific molecules (such as bacterial peptidoglycans) activates serine protease cascades that converge to activate the Toll pathway. Recent data show that the serine protease Grass, which is activated downstream of pattern recognition receptors and was initially thought to be a component only of the Gram-positive bacteria-induced signaling cascade, is also required for the induction of the Toll pathway after fungal infection. Persephone, a serine protease known to be specifically activated by fungal proteases, was also found to be required for sensing Gram-positive bacterial proteases. Thus, Persephone serves as a sensor for microbial activities from both fungi and Gram-positive bacteria. With these new discoveries, a new model has been proposed for activation of the Drosophila Toll pathway.
journal_name
Sci Signaljournal_title
Science signalingauthors
Ashok Ydoi
10.1126/scisignal.252jc1subject
Has Abstractpub_date
2009-01-06 00:00:00pages
jc1issue
52eissn
1945-0877issn
1937-9145pii
2/52/jc1journal_volume
2pub_type
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