Abstract:
:This two-issue series focuses on how understanding how signaling pathways are altered in cancer cells can enable researchers to develop more effective therapies. Cancer is a pleiotropic disease. Tumor cells change over time and, even within a specific tumor, cells may have different mutations and dependencies on different signaling pathways for survival or for metastatic potential. New tools and technologies for genomic- or systems-level analysis, as well as conventional biochemistry and cell biology approaches, are revealing how signaling pathways contribute to cancer development, cancer evolution, and drug resistance.
journal_name
Sci Signaljournal_title
Science signalingauthors
Gough NRdoi
10.1126/scisignal.2004149subject
Has Abstractpub_date
2013-03-26 00:00:00pages
eg3issue
268eissn
1945-0877issn
1937-9145pii
6/268/eg3journal_volume
6pub_type
社论abstract::Fragile X syndrome (FXS) mental retardation is caused by loss-of-function mutations in an RNA-binding protein, fragile X mental retardation protein (FMRP). Previous studies in patients or animal models of FXS have identified alterations in dendritic spine structure, as well as synaptic plasticity induced by metabotrop...
journal_title:Science signaling
pub_type: 杂志文章,评审
doi:10.1126/stke.15pe6
更新日期:2008-02-05 00:00:00
abstract::Microglia mediate neuroprotection and neuropathogenesis but have not been directly associated with behavior. As gatekeepers of the brain's immune system, microglia protect the brain from pathogens but also contribute to inflammation, which may negatively affect neurons. A recent study demonstrates a role for Hoxb8-exp...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.3147jc8
更新日期:2010-11-09 00:00:00
abstract::The vascular endothelial growth factor (VEGF) signaling pathway plays a pivotal role in normal development and also represents a major therapeutic target for tumors and intraocular neovascular disorders. The VEGF receptor tyrosine kinases promote angiogenesis by phosphorylating downstream proteins in endothelial cells...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2003572
更新日期:2013-04-16 00:00:00
abstract::Regulatory factor X (Rfx) homologs regulate the transcription of genes necessary for ciliogenesis in invertebrates and vertebrates. Primary cilia are necessary for Hedgehog signaling and regulation of the activity of the transcriptional regulators known as Gli proteins, which are targets of Hedgehog signaling. Here, w...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2000602
更新日期:2009-11-03 00:00:00
abstract::The aggregation of α-synuclein (αSyn) is considered a key pathophysiological feature of certain neurodegenerative disorders, collectively termed synucleinopathies. Given that a prion-like, cell-to-cell transfer of misfolded αSyn has been recognized in the spreading of αSyn pathology in synucleinopathies, we investigat...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aau4543
更新日期:2019-03-12 00:00:00
abstract::Adenosine 5'-diphosphate (ADP)-ribosylation is a protein posttranslational modification that is catalyzed by ADP-ribosyltransferases (ARTs), using nicotinamide adenine dinucleotide (NAD(+)) as a substrate. Mono-ribosylation can be extended into polymers of ADP-ribose (PAR). Poly(ADP-ribosyl)polymerase (PARP) 1, the be...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2001645
更新日期:2011-05-24 00:00:00
abstract::Phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins play essential roles in DNA-based and RNA-based processes, such as the response to DNA damage, messenger RNA (mRNA) quality control, transcription, and translation, where they contribute to the maintenance of genome integrity and accurate gene...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2000468
更新日期:2010-04-06 00:00:00
abstract::MicroRNAs (miRNAs), key posttranscriptional regulators of many biological processes, have been implicated in many diseases, including cancer. In a recent paper, Avraham and colleagues take a systems biology approach to determine whether and how miRNAs are involved in the regulation of oncogenic signaling networks down...
journal_title:Science signaling
pub_type: 评论,杂志文章,评审
doi:10.1126/scisignal.2002182
更新日期:2011-07-26 00:00:00
abstract::Like phosphorylation, the addition of O-linked beta-N-acetylglucosamine (O-GlcNAcylation) is a ubiquitous, reversible process that modifies serine and threonine residues on nuclear and cytoplasmic proteins. Overexpression of the enzyme that adds O-GlcNAc to target proteins, O-GlcNAc transferase (OGT), perturbs cytokin...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2000526
更新日期:2010-01-12 00:00:00
abstract::Ligand binding to certain heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors (GPCRs) stimulates the rapid synthesis of cyclic adenosine monophosphate (cAMP) through the G protein α(s) subunit, which activates adenylyl cyclase (AC). We found that the transmembrane receptor low-density lipop...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2001464
更新日期:2011-03-15 00:00:00
abstract::Secreted IgD concentration depends on the presence of microbiota. ...
journal_title:Science signaling
pub_type: 评论,杂志文章,评审
doi:10.1126/scisignal.aan0005
更新日期:2017-02-21 00:00:00
abstract::DNAX-activating protein of 12 kD (DAP12) is an immunoreceptor tyrosine-based activation motif (ITAM)-containing adaptor protein found in myeloid cells and natural killer cells, and it couples to various receptors that mediate either cellular activation or inhibition. DAP12 inhibits Toll-like receptor (TLR) signaling, ...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2003801
更新日期:2013-08-20 00:00:00
abstract::Most metazoans have at least some ability to regenerate damaged cells and tissues, although the regenerative capacity varies depending on the species, organ, or developmental stage. Cell replacement and regeneration occur in two contexts: renewal of spent cells during tissue homeostasis (homeostatic growth), and in re...
journal_title:Science signaling
pub_type: 杂志文章,评审
doi:10.1126/scisignal.3145re8
更新日期:2010-10-26 00:00:00
abstract::Antigen-mediated stimulation of the T cell receptor (TCR) triggers activation of nuclear factor κB (NF-κB), a key transcriptional regulator of T cell proliferation and effector cell differentiation. TCR signaling to NF-κB requires both the Carma1-Bcl10-Malt1 (CBM) complex and the inhibitor of κB (IκB) kinase (IKK) com...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2004882
更新日期:2014-05-13 00:00:00
abstract::This two-part lecture introduces students to the scientific computing language MATLAB. Prior computer programming experience is not required. The lectures present basic concepts of computer programming logic that tend to cause difficulties for beginners in addition to concepts that relate specifically to the MATLAB la...
journal_title:Science signaling
pub_type:
doi:10.1126/scisignal.2001984
更新日期:2011-09-13 00:00:00
abstract::Interleukin-10 (IL-10) is an important anti-inflammatory cytokine that is produced primarily by macrophages. We investigated mechanisms by which the timing of IL-10 production was controlled in macrophages and found that cyclin-dependent kinase 5 (CDK5) activity was markedly increased in lipopolysaccharide (LPS)-stimu...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aab3156
更新日期:2015-11-24 00:00:00
abstract::Jasmonates control defense gene expression, growth, and fertility throughout the plant kingdom and have been studied extensively in Arabidopsis thaliana. The prohormone jasmonic acid (JA) is conjugated to amino acids such as isoleucine to form the active hormone jasmonoyl-isoleucine (JA-Ile). A series of breakthroughs...
journal_title:Science signaling
pub_type: 杂志文章,评审
doi:10.1126/scisignal.3109cm4
更新日期:2010-02-16 00:00:00
abstract::The prefibrillar form of soluble amyloid-β (sAβ1-42) impairs synaptic function and is associated with the early phase of Alzheimer's disease (AD). We investigated how sAβ1-42 led to presynaptic defects using a quantum dot-based, single particle-tracking method to monitor synaptic vesicle (SV) trafficking along axons. ...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aam8661
更新日期:2017-07-11 00:00:00
abstract::Mutations in AMPA receptor recycling machinery underlie cognitive impairment in an intellectual disorder and in neurodegenerative diseases. ...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aan5454
更新日期:2017-05-02 00:00:00
abstract::The V600E mutation in the kinase BRAF is frequently detected in melanomas and results in constitutive activation of BRAF, which then promotes cell proliferation by the mitogen-activated protein kinase signaling pathway. Although the BRAFV600E kinase inhibitor vemurafenib has remarkable antitumor activity in patients w...
journal_title:Science signaling
pub_type: 临床试验,杂志文章
doi:10.1126/scisignal.2003057
更新日期:2013-01-29 00:00:00
abstract::The interplay between calcium ion (Ca(2+)) and cyclic adenosine monophosphate (cAMP) signaling underlies crucial aspects of cell homeostasis. The membrane-bound Ca(2+)-regulated adenylyl cyclases (ACs) are pivotal points of this integration. These enzymes display high selectivity for Ca(2+) entry arising from the acti...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2002299
更新日期:2012-04-10 00:00:00
abstract::Plants and animals produce reactive oxygen species (ROS) in response to infection. In plants, ROS not only activate defense responses and promote cell death to limit the spread of pathogens but also restrict the amount of cell death in response to pathogen recognition. Plants also use hormones, such as salicylic acid,...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2004777
更新日期:2014-04-08 00:00:00
abstract::Insulin secretion from pancreatic β cells is controlled by nutrients, hormones, and neurotransmitters. Unlike the latter, which work through classic receptors, glucose and most other nutrients do not interact with membrane receptors but must be metabolized by β cells to induce insulin secretion. Studies have revealed ...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2003325
更新日期:2012-08-28 00:00:00
abstract::Alzheimer's disease (AD) is a progressive dementia disorder characterized by synaptic degeneration and amyloid-β (Aβ) accumulation in the brain. Through whole-genome sequencing of 1345 individuals from 410 families with late-onset AD (LOAD), we identified three highly penetrant variants in PRKCA, the gene that encodes...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aaf6209
更新日期:2016-05-10 00:00:00
abstract::Transitional B cells must actively undergo selection for self-tolerance before maturing into their resting follicular B cell successors. We found that metabolic quiescence was acquired at the follicular B cell stage in both humans and mice. In follicular B cells, the expression of genes involved in ribosome biogenesis...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aaw5573
更新日期:2019-10-22 00:00:00
abstract::Slit proteins act as repulsive axon guidance cues by activating receptors of the Roundabout (Robo) family. During early neurogenesis in Drosophila melanogaster, Slit prevents the growth cones of longitudinal tract neurons from inappropriately crossing the midline, thus restricting these cells to trajectories parallel ...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aam5841
更新日期:2017-06-20 00:00:00
abstract::The CLAVATA (CLV) and flagellin (flg) signaling pathways act through peptide ligands and closely related plasma membrane-localized receptor-like kinases (RLKs). The plant peptide CLV3 regulates stem cell homeostasis, whereas the bacterial flg22 peptide elicits defense responses. We applied multiparameter fluorescence ...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aab0598
更新日期:2015-08-04 00:00:00
abstract::Dickkopf1 (DKK1) was originally identified as an antagonist of Wnt signaling that binds to and induces the clathrin-mediated endocytosis of the Wnt coreceptors low-density lipoprotein receptor-related proteins 5 and 6 (LRP5/6). DKK1 also binds to cytoskeleton-associated protein 4 (CKAP4), which was originally identifi...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aat9519
更新日期:2019-11-19 00:00:00
abstract::The deubiquitylating enzyme OTUB1 is present in all tissues and targets many substrates, in both the cytosol and nucleus. We found that casein kinase 2 (CK2) phosphorylated OTUB1 at Ser(16) to promote its nuclear accumulation in cells. Pharmacological inhibition or genetic ablation of CK2 blocked the phosphorylation o...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aaa0441
更新日期:2015-04-14 00:00:00
abstract::Uncontrolled expression of type I interferon (IFN-I) drives autoimmunity, necessitating the need for tight regulation. In this issue, Cao et al reveal a role for the kinase HIPK2 in the transcriptional control of IFN-I during antiviral immune responses. ...
journal_title:Science signaling
pub_type: 评论,杂志文章,评审
doi:10.1126/scisignal.aaw8549
更新日期:2019-03-19 00:00:00