Abstract:
:The extracellular Ca(2+)-sensing receptor (CaSR) plays a nonredundant role in the functions of the parathyroid gland (PTG) and the kidney. Severe hyperparathyroidism, premature death, and incomplete gene excision in Casr(-/-) mice have precluded the assessment of CaSR function in other tissues. We generated mice with tissue-specific deletion of Casr in the PTG, bone, or cartilage. Deletion of Casr in the PTG or bone resulted in profound bone defects, whereas deletion of Casr in chondrocytes (cartilage-producing cells) resulted in death before embryonic day 13 (E13). Mice in which chondrocyte-specific deletion of Casr was induced between E16 and E18 were viable but showed delayed growth plate development. Our data show a critical role for the CaSR in early embryogenesis and skeletal development.
journal_name
Sci Signaljournal_title
Science signalingauthors
Chang W,Tu C,Chen TH,Bikle D,Shoback Ddoi
10.1126/scisignal.1159945subject
Has Abstractpub_date
2008-09-02 00:00:00pages
ra1issue
35eissn
1945-0877issn
1937-9145pii
1/35/ra1journal_volume
1pub_type
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