Abstract:
:Both synaptic long-term potentiation (LTP) and long-term depression (LTD) are thought to be critical for memory formation. Dell'Acqua and co-workers now demonstrate that transient postsynaptic incorporation of Ca(2+)-permeable (CP) α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) is required for LTD in the exemplary hippocampal CA1 region in 2-week-old mice. Mechanistically, LTD depends on AKAP150-anchored protein kinase A (PKA) to promote the initial functional recruitment of CP-AMPARs during LTD induction and on AKAP150-anchored protein phosphatase 2B (PP2B) to trigger their subsequent removal as part of the lasting depression of synaptic transmission.
journal_name
Sci Signaljournal_title
Science signalingauthors
Hell JWdoi
10.1126/scisignal.aaf7067subject
Has Abstractpub_date
2016-04-26 00:00:00pages
e2issue
425eissn
1945-0877issn
1937-9145pii
9/425/pe2journal_volume
9pub_type
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