Abstract:
:Secretory cells, such as pancreatic beta cells, face the challenge of increasing protein synthesis severalfold during acute or chronic stimulation. This poses a burden on the endoplasmic reticulum (ER), the organelle where proinsulin synthesis and folding takes place. Thus, beta cells use various adaptive mechanisms to adjust the functional capacity of the ER to the prevailing demand. These check-and-balance mechanisms are collectively known as the unfolded protein response (UPR). It remains unclear how UPR signaling is ultimately regulated and what delineates the boundaries between a physiological and a pathological response. New discoveries point to the divergent effects of acute and chronic metabolic fluxes and chemical ER stressors on the formation of complexes among UPR transducers, scaffold proteins, and phosphatases. These and other findings provide a first glimpse on how different signals trigger diverging UPR outcomes.
journal_name
Sci Signaljournal_title
Science signalingauthors
Eizirik DL,Cnop Mdoi
10.1126/scisignal.3110pe7subject
Has Abstractpub_date
2010-02-23 00:00:00pages
pe7issue
110eissn
1945-0877issn
1937-9145pii
scisignal.3110pe7journal_volume
3pub_type
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