Abstract:
:Recent studies have identified adaptations of intracellular signaling pathways and target genes that could contribute or modulate the action of antidepressant drugs, as well as exercise-mediated antidepressant responses. Understanding these adaptations, particularly those changes that are common to diverse antidepressant treatments, is important for the development of more potent and specific treatments of depression. There is growing evidence that growth factors may be important mediators of antidepressant responses. Now, VGF (not an acronym), a neuropeptide that has previously been shown to be involved in maintaining organismal energy balance, as well as in mediating hippocampal synaptic plasticity, may be involved in mediating antidepressant responses. These studies use in vivo approaches to link VGF to the antidepressant-like behavioral effects produced by antidepressant drugs and exercise.
journal_name
Sci Signaljournal_title
Science signalingauthors
Malberg JE,Monteggia LMdoi
10.1126/stke.118pe19subject
Has Abstractpub_date
2008-05-06 00:00:00pages
pe19issue
18eissn
1945-0877issn
1937-9145pii
stke.118pe19journal_volume
1pub_type
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