Abstract:
:Vitamin D receptor represses basal autophagy in breast tissue, which is derepressed by vitamin D, slowing cancer progression.
journal_name
Sci Signaljournal_title
Science signalingauthors
Mushegian AAdoi
10.1126/scisignal.aan2526subject
Has Abstractpub_date
2017-03-21 00:00:00issue
471eissn
1945-0877issn
1937-9145pii
10/471/eaan2526journal_volume
10pub_type
评论,杂志文章abstract::Eps15 homology domain (EHD) proteins are conserved adenosine triphosphatases that are involved in membrane remodeling. EHD family members are structurally similar to the guanosine triphosphatase (GTPase) dynamin, and both are essential for the fission step of clathrin-mediated endocytosis. This Journal Club highlights...
journal_title:Science signaling
pub_type: 杂志文章,评审
doi:10.1126/scisignal.2002989
更新日期:2012-04-24 00:00:00
abstract::Acute cardiorespiratory responses to O2 deficiency are essential for physiological homeostasis. The prototypical acute O2-sensing organ is the carotid body, which contains glomus cells expressing K+ channels whose inhibition by hypoxia leads to transmitter release and activation of nerve fibers terminating in the brai...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aay9452
更新日期:2020-01-21 00:00:00
abstract::Regulatory factor X (Rfx) homologs regulate the transcription of genes necessary for ciliogenesis in invertebrates and vertebrates. Primary cilia are necessary for Hedgehog signaling and regulation of the activity of the transcriptional regulators known as Gli proteins, which are targets of Hedgehog signaling. Here, w...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2000602
更新日期:2009-11-03 00:00:00
abstract::The deubiquitylating enzyme OTUB1 is present in all tissues and targets many substrates, in both the cytosol and nucleus. We found that casein kinase 2 (CK2) phosphorylated OTUB1 at Ser(16) to promote its nuclear accumulation in cells. Pharmacological inhibition or genetic ablation of CK2 blocked the phosphorylation o...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aaa0441
更新日期:2015-04-14 00:00:00
abstract::Defects in the biogenesis of or transport through primary cilia affect Hedgehog protein signaling, and many Hedgehog pathway components traffic through or accumulate in cilia. The Hedgehog receptor Patched negatively regulates the activity and ciliary accumulation of Smoothened, a seven-transmembrane protein that is e...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aaa5622
更新日期:2015-06-02 00:00:00
abstract::Natural killer group 2D (NKG2D), an activating receptor on natural killer (NK) cells and a subset of T cells, recognizes stress-inducible proteins, including MICA and ULBP2, which are present on infected or transformed cells. Whether each NKG2D ligand (NKG2DL) has a distinct biological role is not clear. Using superre...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aal3606
更新日期:2018-04-10 00:00:00
abstract::Deoxyhypusine synthase (DHPS) uses the polyamine spermidine to catalyze the hypusine modification of the mRNA translation factor eIF5A and promotes oncogenesis through poorly defined mechanisms. Because germline deletion of Dhps is embryonically lethal, its role in normal postnatal cellular function in vivo remains un...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aax0715
更新日期:2019-12-03 00:00:00
abstract::This year's signaling breakthroughs highlight insights into the pathogenesis or treatment of cancer, malaria, and neurodegenerative disorders; reveal molecular insights into cell death; and identify signals that could be leveraged to prevent plant parasitism or engineer bacteria as microbial fuel cells. ...
journal_title:Science signaling
pub_type: 社论
doi:10.1126/scisignal.aad9795
更新日期:2016-01-05 00:00:00
abstract::Notch signaling is used to choose cell fates in many developmental contexts. New evidence shows that circulating blood cells in Drosophila, in the absence of Notch ligand provided by neighboring cells, activate Notch signaling through stabilization with the hypoxia-inducible factor-α (HIF-α) transcription factor. Alth...
journal_title:Science signaling
pub_type: 杂志文章,评审
doi:10.1126/scisignal.2002277
更新日期:2011-07-12 00:00:00
abstract::The guanosine triphosphatases of the Rho and Rac subfamilies regulate protumorigenic pathways and are activated by guanine nucleotide exchange factors (Rho GEFs), which could be potential targets for anticancer therapies. We report that two Rho GEFs, Vav2 and Vav3, play synergistic roles in breast cancer by sustaining...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2002962
更新日期:2012-10-02 00:00:00
abstract::Huntington's disease (HD) is a neurodegenerative disease caused by an expansion in the huntingtin protein (also called Htt) that induces neuronal cell death with age. We found that the treatment of 12-month-old symptomatic heterozygous and homozygous zQ175 huntingtin knockin mice for 12 weeks with CTEP, a negative all...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aan6387
更新日期:2017-12-19 00:00:00
abstract::Antigen-mediated stimulation of the T cell receptor (TCR) triggers activation of nuclear factor κB (NF-κB), a key transcriptional regulator of T cell proliferation and effector cell differentiation. TCR signaling to NF-κB requires both the Carma1-Bcl10-Malt1 (CBM) complex and the inhibitor of κB (IκB) kinase (IKK) com...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2004882
更新日期:2014-05-13 00:00:00
abstract::Under drought stress, abscisic acid (ABA) triggers closure of leaf cell pores called stomata, which are formed by two specialized cells called guard cells in plant epidermis. Two pathways downstream of ABA stimulate phosphorylation of the S-type anion channels SLAC1 (slow anion channel associated 1) and SLAH3 (SLAC1 h...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2005703
更新日期:2014-09-09 00:00:00
abstract::Plants and animals produce reactive oxygen species (ROS) in response to infection. In plants, ROS not only activate defense responses and promote cell death to limit the spread of pathogens but also restrict the amount of cell death in response to pathogen recognition. Plants also use hormones, such as salicylic acid,...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2004777
更新日期:2014-04-08 00:00:00
abstract::Phosphoinositide 3-kinases (PI3Ks) are implicated in a broad spectrum of cellular activities, such as growth, proliferation, differentiation, migration, and metabolism. Activation of class I PI3Ks by mutation or overexpression correlates with the development and maintenance of various human cancers. These PI3Ks are he...
journal_title:Science signaling
pub_type: 杂志文章,评审
doi:10.1126/scisignal.2002165
更新日期:2011-10-18 00:00:00
abstract::Progression through mitosis depends on a large number of protein complexes that regulate the major structural and physiological changes necessary for faithful chromosome segregation. Most, if not all, of the mitotic processes are regulated by a set of mitotic protein kinases that control protein activity by phosphoryl...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2001993
更新日期:2011-11-08 00:00:00
abstract::Although many anticancer drugs that target receptor tyrosine kinases (RTKs) provide clinical benefit, their long-term use is limited by resistance that is often attributed to increased abundance or activation of another RTK that compensates for the inhibited receptor. To uncover common and unique features in the signa...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2003994
更新日期:2013-07-16 00:00:00
abstract::For decades, the fission yeast Schizosaccharomyces pombe has been used as an excellent model with which to explore how cellular growth is coordinated with the division cycle, a yet-unanswered question in biology. New studies in this organism show that TOR (target of rapamycin) kinase and stress-responsive MAPK (mitoge...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.296pe74
更新日期:2009-11-10 00:00:00
abstract::Ligand binding to certain heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors (GPCRs) stimulates the rapid synthesis of cyclic adenosine monophosphate (cAMP) through the G protein α(s) subunit, which activates adenylyl cyclase (AC). We found that the transmembrane receptor low-density lipop...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2001464
更新日期:2011-03-15 00:00:00
abstract::Clinical response to chimeric antigen receptor (CAR) T cell therapy is correlated with CAR T cell persistence, especially for CAR T cells that target CD19+ hematologic malignancies. 4-1BB-costimulated CAR (BBζ) T cells exhibit longer persistence after adoptive transfer than do CD28-costimulated CAR (28ζ) T cells. 4-1B...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aay8248
更新日期:2020-03-31 00:00:00
abstract::TRPM2 is a Ca2+-permeable cation channel that is specifically activated by adenosine diphosphoribose (ADPR). Channel activation in the plasma membrane leads to Ca2+ influx and has been linked to apoptotic mechanisms. The primary agonist, ADPR, is produced both extra- and intracellularly and causes increases in intrace...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2000278
更新日期:2009-05-19 00:00:00
abstract::Most metazoans have at least some ability to regenerate damaged cells and tissues, although the regenerative capacity varies depending on the species, organ, or developmental stage. Cell replacement and regeneration occur in two contexts: renewal of spent cells during tissue homeostasis (homeostatic growth), and in re...
journal_title:Science signaling
pub_type: 杂志文章,评审
doi:10.1126/scisignal.3145re8
更新日期:2010-10-26 00:00:00
abstract::Manipulating ligand interactions with the activating receptor NKG2D modulates natural killer cell responses. ...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aan8369
更新日期:2017-05-30 00:00:00
abstract::Calcium/calmodulin-dependent protein kinase II (CaMKII) plays a central role in Ca2+ signaling throughout the body. In the hippocampus, CaMKII is required for learning and memory. Vertebrate genomes encode four CaMKII homologs: CaMKIIα, CaMKIIβ, CaMKIIγ, and CaMKIIδ. All CaMKIIs consist of a kinase domain, a regulator...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aaz0240
更新日期:2020-07-21 00:00:00
abstract::Cardiomyocytes contract against a mechanical load during each heartbeat, and excessive mechanical stress leads to heart diseases. Using a cell-in-gel system that imposes an afterload during cardiomyocyte contraction, we found that nitric oxide synthase (NOS) was involved in transducing mechanical load to alter Ca(2+) ...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2005046
更新日期:2014-03-18 00:00:00
abstract::The mechanisms of context-specific differences in signal transduction, such as those that occur among different cell types, are not fully understood. One possibility is that differences in the abundance of proteins change signaling outputs because these proteins compete for binding to hub proteins at critical network ...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2004560
更新日期:2013-12-17 00:00:00
abstract::Exosomes are paracrine regulators of the tumor microenvironment and contain complex cargo. We previously reported that exosomes released from acute myeloid leukemia (AML) cells can suppress residual hematopoietic stem and progenitor cell (HSPC) function indirectly through stromal reprogramming of niche retention facto...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aaf2797
更新日期:2016-09-06 00:00:00
abstract::Toll-like receptors (TLRs) recognize pathogen-associated molecular patterns (PAMPs) and stimulate the innate immune response through the production of cytokines. The innate immune response depends on the timing of encountering PAMPs, suggesting a short-term "memory." In particular, activation of TLR3 appears to prime ...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aac9340
更新日期:2016-07-12 00:00:00
abstract::Like phosphorylation, the addition of O-linked beta-N-acetylglucosamine (O-GlcNAcylation) is a ubiquitous, reversible process that modifies serine and threonine residues on nuclear and cytoplasmic proteins. Overexpression of the enzyme that adds O-GlcNAc to target proteins, O-GlcNAc transferase (OGT), perturbs cytokin...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2000526
更新日期:2010-01-12 00:00:00
abstract::The extracellular Ca(2+)-sensing receptor (CaSR) plays a nonredundant role in the functions of the parathyroid gland (PTG) and the kidney. Severe hyperparathyroidism, premature death, and incomplete gene excision in Casr(-/-) mice have precluded the assessment of CaSR function in other tissues. We generated mice with ...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.1159945
更新日期:2008-09-02 00:00:00