Abstract:
:Mineralocorticoid receptor (MR) antagonists are effective at treating heart failure. In this issue of Science Signaling, Oakley et al. provide new insight into their cardioprotective actions and highlight the importance of the opposing relationship between the MR and the related glucocorticoid receptor (GR) in the response to cardiomyocyte injury.
journal_name
Sci Signaljournal_title
Science signalingauthors
Chapman KEdoi
10.1126/scisignal.aaw8715subject
Has Abstractpub_date
2019-04-16 00:00:00issue
577eissn
1945-0877issn
1937-9145pii
12/577/eaaw8715journal_volume
12pub_type
杂志文章,评审abstract::Premature labor and consequent neonatal mortality may be prevented by stimulating the expression of PIBF1 in uterine B cells. ...
journal_title:Science signaling
pub_type: 评论,杂志文章
doi:10.1126/scisignal.aam7592
更新日期:2017-01-17 00:00:00
abstract::The extracellular Ca(2+)-sensing receptor (CaSR) plays a nonredundant role in the functions of the parathyroid gland (PTG) and the kidney. Severe hyperparathyroidism, premature death, and incomplete gene excision in Casr(-/-) mice have precluded the assessment of CaSR function in other tissues. We generated mice with ...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.1159945
更新日期:2008-09-02 00:00:00
abstract::Tools for conducting high-throughput kinome analysis do not exist for many species. For example, two commonly used techniques for monitoring phosphorylation events are phosphorylation-specific antibodies and peptide arrays. The majority of phosphorylation-specific antibodies are for human or mouse targets, and the con...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.254pl1
更新日期:2009-01-20 00:00:00
abstract::TRPM2 is a Ca2+-permeable cation channel that is specifically activated by adenosine diphosphoribose (ADPR). Channel activation in the plasma membrane leads to Ca2+ influx and has been linked to apoptotic mechanisms. The primary agonist, ADPR, is produced both extra- and intracellularly and causes increases in intrace...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2000278
更新日期:2009-05-19 00:00:00
abstract::The accumulation of damaged or excess proteins and organelles is a defining feature of metabolic disease in nearly every tissue. Thus, a central challenge in maintaining metabolic homeostasis is the identification, sequestration, and degradation of these cellular components, including protein aggregates, mitochondria,...
journal_title:Science signaling
pub_type: 杂志文章,评审
doi:10.1126/scisignal.aag2298
更新日期:2017-02-28 00:00:00
abstract::Neutrophil extracellular trap (NET) formation can generate short-term, functional anucleate cytoplasts and trigger loss of cell viability. We demonstrated that the necroptotic cell death effector mixed lineage kinase domain-like (MLKL) translocated from the cytoplasm to the plasma membrane and stimulated downstream NA...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aao1716
更新日期:2018-09-04 00:00:00
abstract::Ectodomain shedding mediated by tumor necrosis factor-α (TNF-α)-converting enzyme [TACE; also known as ADAM17 (a disintegrin and metalloproteinase 17)] provides an important switch in regulating cell proliferation, inflammation, and cancer progression. TACE-mediated ectodomain cleavage is activated by signaling of the...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2002689
更新日期:2012-05-01 00:00:00
abstract::Biophysical methods and x-ray crystallography have revealed that class A G protein-coupled receptors (GPCRs) can form homodimers. We combined computational approaches with receptor cross-linking, energy transfer, and a newly developed functional export assay to characterize the residues involved in the dimerization in...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aal2869
更新日期:2018-05-08 00:00:00
abstract::An often-asked question is, Why are there so many different transporters in a cell to take up a particular substrate? At least part of the answer comes from work on the possible competitive advantage of dual-transporter systems. In such systems, low-affinity transporters function when a nutrient is plentiful in the en...
journal_title:Science signaling
pub_type: 杂志文章,评审
doi:10.1126/scisignal.2002837
更新日期:2012-02-07 00:00:00
abstract::A central component of receptor-evoked Ca(2+) signaling is store-operated Ca(2+) entry (SOCE), which is activated by the assembly of STIM1-Orai1 channels in endoplasmic reticulum (ER) and plasma membrane (PM) (ER-PM) junctions in response to depletion of ER Ca(2+). We report that STIM2 enhances agonist-mediated activa...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2005748
更新日期:2015-01-13 00:00:00
abstract::Fgr is a member of the Src family of nonreceptor tyrosine kinases, which are overexpressed and constitutively active in many human cancers. Fgr expression is restricted to myeloid hematopoietic cells and is markedly increased in a subset of bone marrow samples from patients with acute myeloid leukemia (AML). Here, we ...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aat5916
更新日期:2018-10-23 00:00:00
abstract::New therapeutic approaches for chronic inflammatory diseases such as inflammatory bowel disease, rheumatoid arthritis, and psoriasis are needed because current treatments are often suboptimal in terms of both efficacy and the risks of serious adverse events. Inhibitor of apoptosis proteins (IAPs) are E3 ubiquitin liga...
journal_title:Science signaling
pub_type: 杂志文章,评审
doi:10.1126/scisignal.aax8295
更新日期:2020-02-18 00:00:00
abstract::Educated natural killer (NK) cells have inhibitory receptors specific for self major histocompatibility complex (MHC) class I molecules and kill cancer cells more efficiently than do NK cells that do not have such receptors (hyporesponsive NK cells). The mechanism behind this functional empowerment through education h...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aai9200
更新日期:2018-02-13 00:00:00
abstract::The activation of T cells requires the guanine nucleotide exchange factor VAV1. Using mice in which a tag for affinity purification was attached to endogenous VAV1 molecules, we analyzed by quantitative mass spectrometry the signaling complex that assembles around activated VAV1. Fifty VAV1-binding partners were ident...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aar3083
更新日期:2018-07-10 00:00:00
abstract::Interleukin-10 (IL-10) is an important anti-inflammatory cytokine that is produced primarily by macrophages. We investigated mechanisms by which the timing of IL-10 production was controlled in macrophages and found that cyclin-dependent kinase 5 (CDK5) activity was markedly increased in lipopolysaccharide (LPS)-stimu...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aab3156
更新日期:2015-11-24 00:00:00
abstract::The C-terminal guanine nucleotide exchange factor (GEF) module of Trio (TrioC) transfers signals from the Gαq/11 subfamily of heterotrimeric G proteins to the small guanosine triphosphatase (GTPase) RhoA, enabling Gαq/11-coupled G protein-coupled receptors (GPCRs) to control downstream events, such as cell motility an...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aav2449
更新日期:2019-02-19 00:00:00
abstract::Frizzleds (FZDs) are a group of seven transmembrane-spanning (7TM) receptors that belong to class F of the G protein-coupled receptor (GPCR) superfamily. FZDs bind WNT proteins to stimulate diverse signaling cascades involved in embryonic development, stem cell regulation, and adult tissue homeostasis. Frizzled 5 (FZD...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aar5536
更新日期:2018-12-04 00:00:00
abstract::Dimers of conventional transforming growth factor-β (TGF-β) and bone morphogenetic protein (BMP) ligands are composed of two 100- to 140-amino acid peptides that are produced through the proteolytic processing of a proprotein precursor by proconvertases, such as furin. We report the identification of an evolutionarily...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2002549
更新日期:2012-04-03 00:00:00
abstract::In this issue of Science Signaling, Lu et al reveal a role for Parkin-mediated mitophagy in beige-to-white adipocyte transition. In the absence of Parkin, mitochondria in thermogenic beige adipocytes are preserved even after the elimination of cold mimetic stimuli-in contrast to their typical elimination during the wh...
journal_title:Science signaling
pub_type: 评论,杂志文章,评审
doi:10.1126/scisignal.aat1082
更新日期:2018-04-24 00:00:00
abstract::Understanding the complex dynamics of growth factor signaling requires both mechanistic and kinetic information. Although signaling dynamics have been studied for pathways downstream of receptor tyrosine kinases and G protein (heterotrimeric guanine nucleotide-binding protein)-coupled receptors, they have not been inv...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2004416
更新日期:2013-12-10 00:00:00
abstract::Insulin receptor substrate 2 (IRS2) is an adaptor protein that becomes tyrosine-phosphorylated in response to the cytokines interleukin-4 (IL-4) and IL-13, which results in activation of the phosphoinositide 3-kinase (PI3K)-Akt pathway. IL-4 and IL-13 contribute to allergic lung inflammation. To examine the role of IR...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aad6724
更新日期:2016-06-21 00:00:00
abstract::The trimeric intracellular cation (TRIC) channels TRIC-A and TRIC-B localize predominantly to the endoplasmic reticulum (ER) and likely support Ca(2+) release from intracellular stores by mediating cationic flux to maintain electrical neutrality. Deletion and point mutations in TRIC-B occur in families with autosomal ...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aad9055
更新日期:2016-05-17 00:00:00
abstract::For decades, the fission yeast Schizosaccharomyces pombe has been used as an excellent model with which to explore how cellular growth is coordinated with the division cycle, a yet-unanswered question in biology. New studies in this organism show that TOR (target of rapamycin) kinase and stress-responsive MAPK (mitoge...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.296pe74
更新日期:2009-11-10 00:00:00
abstract::Teaching the practical aspects of signal transduction to large undergraduate classes can be challenging when there is only a finite time frame in which to engage in laboratory activities. This teaching resource describes the use of bead-based ALPHAscreen technology for a class of 300 second-year biochemistry students,...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.262tr1
更新日期:2009-03-17 00:00:00
abstract::This week, Science Signaling highlights research that uses computational and cell biology approaches to uncover the molecular mechanisms underlying diseases of the central nervous system. In particular, research featured explores the neuronal response to stress due to excess excitatory stimuli, multiple roles for pres...
journal_title:Science signaling
pub_type: 杂志文章,评审
doi:10.1126/scisignal.2004456
更新日期:2013-07-09 00:00:00
abstract::Cyclic-di-GMP (c-di-GMP) is a bacterial second messenger that transduces internal and external signals and regulates bacterial motility and biofilm formation. Some organisms encode more than 100 c-di-GMP-modulating enzymes, but only for a few has a signal been defined that modulates their activity. We developed and ap...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aaa1796
更新日期:2015-06-09 00:00:00
abstract::Signaling proteins evolved diverse interactions to provide specificity for distinct stimuli. Signaling complexity in the G protein (heterotrimeric guanosine triphosphate-binding protein) network was achieved in animals through subunit duplication and incremental evolution. By combining comprehensive and quantitative p...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aaf9558
更新日期:2016-09-20 00:00:00
abstract::The oral bacterium Fusobacterium nucleatum is often found in colorectal cancer (CRC). In the 21 July 2020 issue of Science Signaling, Casasanta et al show that CRC cell-resident F. nucleatum promotes cytokine secretion that may potentiate tumor growth and metastatic progression in patients. ...
journal_title:Science signaling
pub_type: 杂志文章,评审
doi:10.1126/scisignal.abc4218
更新日期:2020-08-11 00:00:00
abstract::Regulatory factor X (Rfx) homologs regulate the transcription of genes necessary for ciliogenesis in invertebrates and vertebrates. Primary cilia are necessary for Hedgehog signaling and regulation of the activity of the transcriptional regulators known as Gli proteins, which are targets of Hedgehog signaling. Here, w...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2000602
更新日期:2009-11-03 00:00:00
abstract::A system-wide analysis of cell signaling requires detecting and quantifying many different proteins and their posttranslational modification states in the same cellular sample. Here, we present Protocols for two miniaturized, array-based methods, one of which provides detailed information on a central signaling protei...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2002372
更新日期:2012-01-10 00:00:00