Abstract:
:An often-asked question is, Why are there so many different transporters in a cell to take up a particular substrate? At least part of the answer comes from work on the possible competitive advantage of dual-transporter systems. In such systems, low-affinity transporters function when a nutrient is plentiful in the environment, and the abundance of high-affinity transporters is increased when that nutrient becomes scarce. A dual-transporter system enabled a long "preparation phase" to occur during which cells induce gene expression as they become increasingly starved. Surprisingly, the preparation phase is important not for growth under low-nutrient conditions but rather for fluctuating nutrient amounts as commonly occurs in nature. Thus, this creative study provides a previously unconsidered explanation for the abundance of dual-transporter systems in biology.
journal_name
Sci Signaljournal_title
Science signalingauthors
Eide DJdoi
10.1126/scisignal.2002837subject
Has Abstractpub_date
2012-02-07 00:00:00pages
pe5issue
210eissn
1945-0877issn
1937-9145pii
scisignal.2002837journal_volume
5pub_type
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