当前位置： SCI文献检索 > MEDICAL PHYSICS期刊下所有文献 > Feasibility of estimating regional mechanical properties of cerebral aneurysms in vivo.

Feasibility of estimating regional mechanical properties of cerebral aneurysms in vivo.

Abstract：

PURPOSE:In this article, the authors studied the feasibility of estimating regional mechanical properties in cerebral aneurysms, integrating information extracted from imaging and physiological data with generic computational models of the arterial wall behavior. METHODS:A data assimilation framework was developed to incorporate patient-specific geometries into a given biomechanical model, whereas wall motion estimates were obtained from applying registration techniques to a pair of simulated MR images and guided the mechanical parameter estimation. A simple incompressible linear and isotropic Hookean model coupled with computational fluid-dynamics was employed as a first approximation for computational purposes. Additionally, an automatic clustering technique was developed to reduce the number of parameters to assimilate at the optimization stage and it considerably accelerated the convergence of the simulations. Several in silico experiments were designed to assess the influence of aneurysm geometrical characteristics and the accuracy of wall motion estimates on the mechanical property estimates. Hence, the proposed methodology was applied to six real cerebral aneurysms and tested against a varying number of regions with different elasticity, different mesh discretization, imaging resolution, and registration configurations. RESULTS:Several in silico experiments were conducted to investigate the feasibility of the proposed workflow, results found suggesting that the estimation of the mechanical properties was mainly influenced by the image spatial resolution and the chosen registration configuration. According to the in silico experiments, the minimal spatial resolution needed to extract wall pulsation measurements with enough accuracy to guide the proposed data assimilation framework was of 0.1 mm. CONCLUSIONS:Current routine imaging modalities do not have such a high spatial resolution and therefore the proposed data assimilation framework cannot currently be used on in vivo data to reliably estimate regional properties in cerebral aneurysms. Besides, it was observed that the incorporation of fluid-structure interaction in a biomechanical model with linear and isotropic material properties did not have a substantial influence in the final results.

journal_name

Med Phys

journal_title

Medical physics

authors

Balocco S,Camara O,Vivas E,Sola T,Guimaraens L,Gratama van Andel HA,Majoie CB,Pozo JM,Bijnens BH,Frangi AF

doi

10.1118/1.3355933

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

1689-706

issue

eissn

0094-2405

issn

2473-4209

journal_volume

pub_type

杂志文章

在线工具

Feasibility of estimating regional mechanical properties of cerebral aneurysms in vivo.