Aptamers, the bivalent agents as probes and therapies for coronavirus infections: A systematic review.

Abstract:

:The recently known coronavirus, SARS-CoV-2, has turn into the greatest global health challenge, affecting a large number of societies. The lack of specific treatment and gold-standard diagnostic system has made the situation more complicated. Efforts have led to production of several diagnostic kits that are associated with limitations such as inadequate sensitivity and accuracy. Aptamers as multipotent biological probes could be promising candidates to design sensitive and specific biosensors. Although few studies have introduced specific aptamer types of coronavirus, they may help us select the best approach to obtain specific aptamers for this virus. On the other hand, some of already-introduced aptamers have shown the inhibitory effects on coronavirus that could be applied as therapeutics. The present study has provided a systematic overview on use of aptamer-based biosensors and drugs to diagnose and treat coronavirus.

journal_name

Mol Cell Probes

authors

Torabi R,Ranjbar R,Halaji M,Heiat M

doi

10.1016/j.mcp.2020.101636

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

101636

eissn

0890-8508

issn

1096-1194

pii

S0890-8508(20)30264-4

journal_volume

53

pub_type

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