Pulmonary formulations: what remains to be done?

Abstract:

:Significant advances have been made in the last 50 years in developing safe and efficacious aerosol formulations for pulmonary delivery. The key to future innovation may lie at the interface between biology and particle engineering. Improved understanding of biological processes including particle clearance, cellular targeting, intracellular trafficking, and drug absorption are needed to better design formulations that deliver to the "target" with the optimal balance of pharmacodynamic, pharmacokinetic, and safety profiles. More specifically, continued advances are needed in the development of: (1) controlled release formulations; (2) formulations with improved regional targeting within the lungs (e.g., airway versus alveoli and vice versa); (3) formulations containing active targeting moieties; (4) formulation strategies for improving the systemic bioavailability of inhaled macromolecules; (5) formulation strategies for delivering macromolecules, including siRNA and DNA into cells; and (f) formulations with improved dose consistency. It is likely that such innovation will require the development of novel excipients and particle engineering strategies. Future innovation must also take into the account the changing marketplace and the diverse set of customers (patient, healthcare professional, heath authorities, payers, and politicians) who must be satisfied. The pharmacoeconomics of new delivery systems will be closely scrutinized, so it is imperative that cost factors be taken into account. Otherwise, the new technology option may overshoot the evolving inhalation marketplace.

authors

Weers JG,Bell J,Chan HK,Cipolla D,Dunbar C,Hickey AJ,Smith IJ

doi

10.1089/jamp.2010.0838

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

S5-23

eissn

1941-2711

issn

1941-2703

journal_volume

23 Suppl 2

pub_type

杂志文章,评审
  • Decreased level of PDCD4 (programmed cell death 4) protein activated cell proliferation in the lung of A/J mouse.

    abstract:BACKGROUND:Programmed cell death 4 (PDCD4), a protein that binds to eukaryotic initiation factor 4A (eIF4A), inhibits the initiation of translation. Although a number of tumor suppressors target transcription, Pdcd4 is the first suppressor targeting protein translation, and has also been suggested to function as a tumo...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2009.0778

    authors: Hwang SK,Minai-Tehrani A,Lim HT,Shin JY,An GH,Lee KH,Park KR,Kim YS,Beck GR Jr,Yang HS,Cho MH

    更新日期:2010-10-01 00:00:00

  • Targeting aerosolized drugs to the conducting airways using very large particles and extremely slow inhalations.

    abstract:BACKGROUND:The site of deposition in the respiratory tract for aerosolized, inhaled therapeutic drugs depends on both the particles' aerodynamic size and the patient's breathing pattern. METHODS:In 21 healthy subjects with normal lung function, we evaluated an extremely slow inhalation of a large 9.5-μm MMAD particle ...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2008.0711

    authors: Zeman KL,Wu J,Bennett WD

    更新日期:2010-12-01 00:00:00

  • Toward modern inhalational bacteriophage therapy: nebulization of bacteriophages of Burkholderia cepacia complex.

    abstract::Antibiotic-resistant bacterial infections have renewed interest in finding substitute methods of treatment. The purpose of the present in vitro study was to investigate the possibility of respiratory delivery of a Burkholderia cepacia complex (BCC) bacteriophage by nebulized aerosol administration. Bacteriophages in i...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2008.0701

    authors: Golshahi L,Seed KD,Dennis JJ,Finlay WH

    更新日期:2008-12-01 00:00:00

  • Deposition Mechanisms.

    abstract::The success of inhalation therapy is not only dependent upon the pharmacology of the drugs being inhaled but also upon the site and extent of deposition in the respiratory tract. Similarly, the toxicity of environmental and industrial particulate matter is affected not only by the nature of the dust but also by the am...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2020.29029.cd

    authors: Darquenne C

    更新日期:2020-08-01 00:00:00

  • Single-dose pharmacokinetics and safety pharmacodynamics of formoterol delivered by two different dry powder inhalers.

    abstract::The present study aimed at assessing the pharmacokinetics (PK) and safety pharmacodynamics (PD) of 24 microg formoterol delivered via a Novolizer and via an Aerolizer in healthy subjects. This was a randomized, open-label, crossover study. Beside PK, serum potassium, and glucose profiles, vital signs, and ECG were rec...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/jamp.2008.0690

    authors: Petzold U,Kremer HJ,Nguyen DT,Munzel U,Dietrich H,Maus J

    更新日期:2008-09-01 00:00:00

  • Optimal delivery of aerosols to infants during mechanical ventilation.

    abstract:PURPOSE:The objective of this study was to determine optimal aerosol delivery conditions for a full-term (3.6 kg) infant receiving invasive mechanical ventilation by evaluating the effects of aerosol particle size, a new wye connector, and timing of aerosol delivery. METHODS:In vitro experiments used a vibrating mesh ...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2013.1077

    authors: Longest PW,Azimi M,Hindle M

    更新日期:2014-10-01 00:00:00

  • Investigation of Lung Pharmacokinetic of the Novel PDE4 Inhibitor CHF6001 in Preclinical Models: Evaluation of the PreciseInhale Technology.

    abstract:BACKGROUND:Preclinical evaluation of new chemical entities (NCEs) designed to be administered by inhalation route requires lung administration to rodents, especially in the discovery phase. Different administration methods have been used until now, but more efforts are required to obtain controlled and reproducible lun...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2017.1369

    authors: Fioni A,Selg E,Cenacchi V,Acevedo F,Brogin G,Gerde P,Puccini P

    更新日期:2018-02-01 00:00:00

  • Community Masks During the SARS-CoV-2 Pandemic: Filtration Efficacy and Air Resistance.

    abstract:: Background: Many countries have introduced a compulsory use of community masks for certain public areas during the SARS-CoV-2 pandemic. Different manufacturers offer reusable community masks in large quantities. The efficacy of these masks, however, is unknown. ...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2020.1635

    authors: Maurer L,Peris D,Kerl J,Guenther F,Koehler D,Dellweg D

    更新日期:2020-09-23 00:00:00

  • Spiromax, a New Dry Powder Inhaler: Dose Consistency under Simulated Real-World Conditions.

    abstract:BACKGROUND:Spiromax(®) is a novel dry powder inhaler for patients with asthma or chronic obstructive pulmonary disease (COPD). The studies presented here provide further data on attributes (in vitro dosing consistency with budesonide-formoterol (DuoResp) Spiromax; flow rates through empty versions of the Spiromax and T...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2015.1216

    authors: Canonica GW,Arp J,Keegstra JR,Chrystyn H

    更新日期:2015-10-01 00:00:00

  • Controlled, Parametric, Individualized, 2-D and 3-D Imaging Measurements of Aerosol Deposition in the Respiratory Tract of Asthmatic Human Subjects for Model Validation.

    abstract:BACKGROUND:Computer modeling is used to predict inhaled aerosol deposition in the lung based on definition of the aerosol characteristics and the breathing pattern and airway anatomy of the subject. Validation of the models is limited by the lack of detailed experimental data. Three-dimensional imaging provides an oppo...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2014.1191

    authors: Fleming J,Conway J,Majoral C,Katz I,Caillibotte G,Pichelin M,Montesantos S,Bennett M

    更新日期:2015-12-01 00:00:00

  • The effects of training on inhaler technique and quality of life in patients with COPD.

    abstract:OBJECTIVES:This experimental study was conducted to determine the effects of training on inhaler technique and quality of life in patients with chronic obstructive pulmonary disease (COPD). METHODS:Among the patients who applied at the outpatient clinic of chest diseases between March 2009 and May 2010, a total of 69 ...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/jamp.2012.1017

    authors: Göriş S,Taşci S,Elmali F

    更新日期:2013-12-01 00:00:00

  • Correcting Photo Reflection Method Output and Its Application in the Dynamic Analysis of Particle Release from Dry Powder Inhalers.

    abstract:: Background: The photo reflection method (PRM) is used to measure light reflected from particles released from dry powder inhalers (DPIs). This simple method depicts time trajectories of released drugs; however, it underestimates the number of particles at high peak inhalat...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2020.1610

    authors: Kondo T,Hibino M,Tanigaki T,Tajiri S,Horiuchi S

    更新日期:2020-11-04 00:00:00

  • Inhaled insulin: too soon to be forgotten?

    abstract::Inhalation is a potentially viable route of administration for numerous agents. In diabetes mellitus, the need for frequent injections to achieve ideal glycemic control remains a significant limitation for initiating and complying with insulin therapy in a large number of patients. To overcome this barrier, inhaled in...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章,评审

    doi:10.1089/jamp.2011.0876

    authors: Zarogoulidis P,Papanas N,Kouliatsis G,Spyratos D,Zarogoulidis K,Maltezos E

    更新日期:2011-10-01 00:00:00

  • Using MRI to measure aerosol deposition.

    abstract::This article provides a concise review of the use of magnetic resonance imaging (MRI) for measurement of regional aerosol deposition in the lungs. Basic aspects of MRI and its use in lung imaging and measurement of regional ventilation are introduced. Imaging of hydrogen protons (water) and inhaled hyperpolarized gase...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章,评审

    doi:10.1089/jamp.2011.0897

    authors: Thompson RB,Finlay WH

    更新日期:2012-04-01 00:00:00

  • Development of an in vitro model to assess deposition of aerosol particles in a representative replica of the rat's respiratory tract.

    abstract:BACKGROUND:Small rodents continue to be the mainstay for the assessment of pharmacological and toxicological data of inhaled therapeutics. For meaningful interpretation of the results information about deposition of aerosol particles in the respiratory tract is warranted, but not trivial to obtain for animals with nose...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2011.0902

    authors: Ahmed A,Prime D,Burnell PK,Högger P

    更新日期:2012-06-01 00:00:00

  • Systemic delivery of atropine sulfate by the MicroDose Dry-Powder Inhaler.

    abstract:BACKGROUND:Inhaled atropine is being developed as a systemic and pulmonary treatment for the extended recovery period after chemical weapons exposure. We performed a pharmacokinetics study comparing inhaled atropine delivery using the MicroDose Therapeutx Dry Powder Inhaler (DPIA) with intramuscular (IM) atropine deliv...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/jamp.2011.0948

    authors: Corcoran TE,Venkataramanan R,Hoffman RM,George MP,Petrov A,Richards T,Zhang S,Choi J,Gao YY,Oakum CD,Cook RO,Donahoe M

    更新日期:2013-02-01 00:00:00

  • An Apparatus to Deliver Mannitol Powder for Bronchial Provocation in Children Under Six Years Old.

    abstract:BACKGROUND:Currently bronchial provocation testing (BPT) using mannitol powder cannot be performed in children under 6 years. A primary reason is it is challenging for children at this age to generate a consistent inspiratory effort to inhale mannitol efficiently from a dry powder inhaler. A prototype system, which doe...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2015.1208

    authors: Tang P,Leung SS,Hor E,Ruzycki CA,Carrigy NB,Finlay WH,Brannan JD,Devadason S,Anderson SD,Sly PD,Samnick K,Chan HK

    更新日期:2015-12-01 00:00:00

  • Characterization of Medication Velocity and Size Distribution from Pressurized Metered-Dose Inhalers by Phase Doppler Anemometry.

    abstract:BACKGROUND:Particle size and velocity are two of the most significant factors that impact the deposition of pressurized metered-dose inhaler (pMDI) sprays in the mouth cavity. pMDIs are prominently used around the world in the treatment of patients suffering from a variety of lung diseases such as asthma and chronic ob...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2015.1264

    authors: Alatrash A,Matida E

    更新日期:2016-12-01 00:00:00

  • Pulmonary Toxicity of Benzalkonium Chloride.

    abstract::The available toxicity data of benzalkonium chloride (BKC) clearly shows that it is toxic; however, the weight of evidence favors the view that at doses encountered in nasally and orally inhaled pharmaceutical preparations it is well tolerated. The adverse toxicological data predominantly come from in vitro and animal...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章,评审

    doi:10.1089/jamp.2017.1390

    authors: Johnson NF

    更新日期:2018-02-01 00:00:00

  • The Impact of Common Inhaler Errors on Drug Delivery: Investigating Critical Errors with a Dry Powder Inhaler.

    abstract:BACKGROUND:Researchers, using checklists, have identified that 30%-90% of patients make errors in inhaler use. It is not certain whether these errors affect the delivery of medication. We have developed an electronic monitor (INCA™) that records audio each time an inhaler is used, providing objective information on inh...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2016.1334

    authors: Sulaiman I,Seheult J,Sadasivuni N,MacHale E,Killane I,Giannoutsos S,Cushen B,Mokoka MC,Bhreathnach AS,Boland F,Reilly RB,Costello RW

    更新日期:2017-08-01 00:00:00

  • Collecting exhaled breath condensate (EBC) with two condensers in series: a promising technique for studying the mechanisms of EBC formation, and the volatility of selected biomarkers.

    abstract::Exhaled breath condensate (EBC) consists mainly of water, but also contains semivolatile and nonvolatile compounds. The aim of this study was to develop a system in which two condensers are simultaneously used in series to clarify the mechanisms of EBC condensation. Two aliquots of EBC (EBC1 and EBC2) were collected f...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2007.0644

    authors: Corradi M,Goldoni M,Caglieri A,Folesani G,Poli D,Corti M,Mutti A

    更新日期:2008-03-01 00:00:00

  • Adapting the Aerogen Mesh Nebulizer for Dried Aerosol Exposures Using the PreciseInhale Platform.

    abstract:: Background: Many substances used in inhalation research are water soluble and can be administered as nebulized solutions. Typical examples are therapeutic, small-molecular agents, or macromolecules. Another category is a number of water-soluble agents used for airway diagn...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2019.1554

    authors: Gerde P,Nowenwik M,Sjöberg CO,Selg E

    更新日期:2020-04-01 00:00:00

  • Vitamin A Supplementation by Endotracheal Application of a Nano-encapsulated Preparation Is Feasible in Ventilated Preterm Lambs.

    abstract:BACKGROUND:Vitamin A (VA) is crucial for lung growth and development. In premature infants, inadequate VA levels are associated with an increased risk of bronchopulmonary dysplasia (BPD). Intramuscular VA supplementation has been shown to decrease the incidence of BPD, but is not widely used in the clinical setting due...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2017.1438

    authors: Wahl HB,Hütten MC,Monz D,Tutdibi E,Ophelders D,Nikiforou M,Tschernig T,Gortner L,Nohr D,Biesalski HK,Kramer BW

    更新日期:2018-12-01 00:00:00

  • Intranasal Deposition of Accuspray™ Aerosol in Anatomically Correct Models of 2-, 5-, and 12-Year-Old Children.

    abstract:BACKGROUND:To our knowledge, quantification of intranasal deposition of aerosol generated by Accuspray(™) (AS) in children has never been published. We hypothesized that deposition would vary significantly with age and with placement of the device within, or outside, of the nostril. METHODS:We tested these hypotheses ...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2014.1174

    authors: Laube BL,Sharpless G,Vikani AR,Harrand V,Zinreich SJ,Sedberry K,Knaus D,Barry J,Papania M

    更新日期:2015-10-01 00:00:00

  • The co-imaging of gamma camera measurements of aerosol deposition and respiratory anatomy.

    abstract::The use of gamma camera imaging following the inhalation of a radiolabel has been widely used by researchers to investigate the fate of inhaled aerosols. The application of two-dimensional (2D) planar gamma scintigraphy and single-photon emission computed tomography (SPECT) to the study of inhaled aerosols is discusse...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章,评审

    doi:10.1089/jamp.2011.0960

    authors: Conway J,Fleming J,Bennett M,Havelock T

    更新日期:2013-06-01 00:00:00

  • Effect of Posture on Regional Deposition of Coarse Particles in the Healthy Human Lung.

    abstract:BACKGROUND:Understanding the regional partition of deposition of inhaled particles within the lung is important for improving targeted delivery of inhaled aerosolized drugs. One factor affecting regional deposition is gravity. As the lung deforms under its own weight, changes in lung volume, in airway geometries, and i...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2014.1189

    authors: Sá RC,Zeman KL,Bennett WD,Prisk GK,Darquenne C

    更新日期:2015-12-01 00:00:00

  • A Novel In-Line Delivery System to Administer Dry Powder Mannitol to Mechanically Ventilated Patients.

    abstract:BACKGROUND:Mechanically ventilated patients commonly suffer from ventilator-associated pneumonia, hypoxemia, and other lower respiratory tract infection as a result of pathogen colonization and poor sputum clearance. Consequently, there is a high rate of morbidity and mortality in these patients. Dry powder mannitol in...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2016.1320

    authors: Feng B,Tang P,Leung SS,Dhanani J,Chan HK

    更新日期:2017-04-01 00:00:00

  • Model Calculations of Regional Deposition and Disposition for Single Doses of Inhaled Liposomal and Dry Powder Ciprofloxacin.

    abstract:BACKGROUND:Model predictions of regional deposition in the respiratory tract are useful in assessing factors that influence the effectiveness of aerosol delivery. Regional deposition models have previously been coupled with models of mucous production and clearance to estimate initial concentrations of drug deposited i...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2017.1377

    authors: Martin AR,Finlay WH

    更新日期:2018-02-01 00:00:00

  • Adapting the Abbreviated Impactor Measurement (AIM) concept to make appropriate inhaler aerosol measurements to compare with clinical data: a scoping study with the "Alberta" idealized throat (AIT) inlet.

    abstract:BACKGROUND:The Abbreviated Impactor Measurement (AIM) concept simplifies determination of aerodynamic size metrics for inhaler quality control testing. A similar approach is needed to compare in vitro particle size distribution metrics with human respiratory tract (HRT) deposition. METHODS:An abbreviated impactor base...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2011.0925

    authors: Mitchell J,Copley M,Sizer Y,Russell T,Solomon D

    更新日期:2012-08-01 00:00:00

  • A New Quantitative Method for Evaluating Dry Powder Inhalation Efficiency in Asthma Patients.

    abstract:PURPOSE:Many methods have been developed to evaluate dry powder inhalation techniques and their efficiency for disease control in asthma patients. However, it is difficult to apply these methods to clinical practice and research. In this study, we introduce a simple new method that can be applied to dry powder inhalati...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2014.1193

    authors: Liang Y,Hu H,Tian C,Lei Y,Liu C,Luo F

    更新日期:2016-10-01 00:00:00