Pulmonary formulations: what remains to be done?

abstract：BACKGROUND:The site of deposition in the respiratory tract for aerosolized, inhaled therapeutic drugs depends on both the particles' aerodynamic size and the patient's breathing pattern. METHODS:In 21 healthy subjects with normal lung function, we evaluated an extremely slow inhalation of a large 9.5-μm MMAD particle ...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Zeman KL,Wu J,Bennett WD

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Programmed cell death 4 (PDCD4), a protein that binds to eukaryotic initiation factor 4A (eIF4A), inhibits the initiation of translation. Although a number of tumor suppressors target transcription, Pdcd4 is the first suppressor targeting protein translation, and has also been suggested to function as a tumo...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Hwang SK,Minai-Tehrani A,Lim HT,Shin JY,An GH,Lee KH,Park KR,Kim YS,Beck GR Jr,Yang HS,Cho MH

更新日期：2010-10-01 00:00:00

abstract：PURPOSE:Many methods have been developed to evaluate dry powder inhalation techniques and their efficiency for disease control in asthma patients. However, it is difficult to apply these methods to clinical practice and research. In this study, we introduce a simple new method that can be applied to dry powder inhalati...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Liang Y,Hu H,Tian C,Lei Y,Liu C,Luo F

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Inhaled alpha1-antitrypsin (AAT) is being developed for treatment of cystic fibrosis to protect the lungs from excessive free elastase. High drug costs mandate a very efficient aerosol system to deliver a high payload to the airways. The I-neb Adaptive Aerosol Delivery (AAD) System is a portable, electronic,...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Geller DE,Kesser KC

更新日期：2010-04-01 00:00:00

abstract：:Upper respiratory tract infections (URTIs), primarily acute rhinopharyngitis, tonsillitis, adenoiditis, and rhinosinusitis (RS), are major causes of morbidity in both children and adults of any age. In addition to the frequent occurrence of related medical problems and the associated socioeconomic costs, URTIs have a ...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Esposito S,Rosazza C,Sciarrabba CS,Principi N

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:To validate the 'Test of Adherence to Inhalers' (TAI), a 12-item questionnaire designed to assess the adherence to inhalers in patients with COPD or asthma. METHODS:A total of 1009 patients with asthma or COPD participated in a cross-sectional multicenter study. Patients with electronic adherence ≥80% were ...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Plaza V,Fernández-Rodríguez C,Melero C,Cosío BG,Entrenas LM,de Llano LP,Gutiérrez-Pereyra F,Tarragona E,Palomino R,López-Viña A,TAI Study Group.

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:The Abbreviated Impactor Measurement (AIM) concept simplifies determination of aerodynamic size metrics for inhaler quality control testing. A similar approach is needed to compare in vitro particle size distribution metrics with human respiratory tract (HRT) deposition. METHODS:An abbreviated impactor base...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Mitchell J,Copley M,Sizer Y,Russell T,Solomon D

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Use of a valved holding chamber (VHC) in conjunction with a pressurized metered dose inhaler (pMDI) can reduce issues relating to poor actuation-inhalation coordination and potentially improve the lung deposition of aerosol, compared with use of a pMDI alone. However, the performance of a VHC is influenced b...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Hatley RH,von Hollen D,Sandell D,Slator L

更新日期：2014-08-01 00:00:00

abstract：: Background: The photo reflection method (PRM) is used to measure light reflected from particles released from dry powder inhalers (DPIs). This simple method depicts time trajectories of released drugs; however, it underestimates the number of particles at high peak inhalat...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Kondo T,Hibino M,Tanigaki T,Tajiri S,Horiuchi S

更新日期：2020-11-04 00:00:00

abstract：BACKGROUND:Vitamin A (VA) is crucial for lung growth and development. In premature infants, inadequate VA levels are associated with an increased risk of bronchopulmonary dysplasia (BPD). Intramuscular VA supplementation has been shown to decrease the incidence of BPD, but is not widely used in the clinical setting due...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Wahl HB,Hütten MC,Monz D,Tutdibi E,Ophelders D,Nikiforou M,Tschernig T,Gortner L,Nohr D,Biesalski HK,Kramer BW

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Spiromax(®) is a novel dry powder inhaler for patients with asthma or chronic obstructive pulmonary disease (COPD). The studies presented here provide further data on attributes (in vitro dosing consistency with budesonide-formoterol (DuoResp) Spiromax; flow rates through empty versions of the Spiromax and T...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Canonica GW,Arp J,Keegstra JR,Chrystyn H

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:The delivery of antitubercular drugs through direct lung targeting can lead to reduction in the dose as well as side effects of the drug. In the present investigation, carrier (lactose)-based dry-powder inhaler of rifampicin was prepared to achieve direct targeting of the drug into the lungs. METHODS:The dr...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Rawal T,Kremer L,Halloum I,Butani S

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Model predictions of regional deposition in the respiratory tract are useful in assessing factors that influence the effectiveness of aerosol delivery. Regional deposition models have previously been coupled with models of mucous production and clearance to estimate initial concentrations of drug deposited i...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Martin AR,Finlay WH

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Researchers, using checklists, have identified that 30%-90% of patients make errors in inhaler use. It is not certain whether these errors affect the delivery of medication. We have developed an electronic monitor (INCA™) that records audio each time an inhaler is used, providing objective information on inh...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Sulaiman I,Seheult J,Sadasivuni N,MacHale E,Killane I,Giannoutsos S,Cushen B,Mokoka MC,Bhreathnach AS,Boland F,Reilly RB,Costello RW

更新日期：2017-08-01 00:00:00

abstract：:Flexhaler is a multiple-dose, inspiratory flow-driven dry powder inhaler that is a newer version of Turbuhaler, and is identical to the Symbicort Turbuhaler. Sustained performance is of the utmost importance to ensure consistent drug delivery throughout the lifespan of the inhaler. We report functionality testing resu...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Lööf T,Elfman P,Ström P,Törngren A,Borgström L

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:The effectiveness of metered-dose inhalers (MDIs) in delivering medication to the lungs highly depends on its correct usage technique. Current guidelines state optimal technique for high lung deposition should include a slow inhalation (>5 seconds) at an inspiratory flow rate of 30 L/min and inhaler actuatio...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Biswas R,Hanania NA,Sabharwal A

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:The Respimat Soft Mist Inhaler is reported to generate an aerosol with low spray momentum and a small droplet size. However, the transport characteristics of the Respimat aerosol are not well understood. The objective of this study was to characterize the transport and deposition of an aerosol emitted from t...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Worth Longest P,Hindle M

更新日期：2009-06-01 00:00:00

abstract：:Exhaled breath condensate (EBC) consists mainly of water, but also contains semivolatile and nonvolatile compounds. The aim of this study was to develop a system in which two condensers are simultaneously used in series to clarify the mechanisms of EBC condensation. Two aliquots of EBC (EBC1 and EBC2) were collected f...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Corradi M,Goldoni M,Caglieri A,Folesani G,Poli D,Corti M,Mutti A

更新日期：2008-03-01 00:00:00

abstract：:The present study aimed at assessing the pharmacokinetics (PK) and safety pharmacodynamics (PD) of 24 microg formoterol delivered via a Novolizer and via an Aerolizer in healthy subjects. This was a randomized, open-label, crossover study. Beside PK, serum potassium, and glucose profiles, vital signs, and ECG were rec...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Petzold U,Kremer HJ,Nguyen DT,Munzel U,Dietrich H,Maus J

更新日期：2008-09-01 00:00:00

abstract：PURPOSE:The objective of this study was to determine optimal aerosol delivery conditions for a full-term (3.6 kg) infant receiving invasive mechanical ventilation by evaluating the effects of aerosol particle size, a new wye connector, and timing of aerosol delivery. METHODS:In vitro experiments used a vibrating mesh ...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Longest PW,Azimi M,Hindle M

更新日期：2014-10-01 00:00:00

abstract：: Background: Salvia miltiorrhiza polyphenolic acid (SMPA) is effective in the treatment of cardiovascular diseases and currently it is administered orally or intravenously. However, SMPA is poorly absorbed orally and quickly eliminated in vivo. A long-term frequent intraveno...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Lu P,Xing Y,Peng H,Liu Z,Zhou QT,Xue Z,Ma Z,Kebebe D,Zhang B,Liu H

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:To our knowledge, quantification of intranasal deposition of aerosol generated by Accuspray(™) (AS) in children has never been published. We hypothesized that deposition would vary significantly with age and with placement of the device within, or outside, of the nostril. METHODS:We tested these hypotheses ...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Laube BL,Sharpless G,Vikani AR,Harrand V,Zinreich SJ,Sedberry K,Knaus D,Barry J,Papania M

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Small rodents continue to be the mainstay for the assessment of pharmacological and toxicological data of inhaled therapeutics. For meaningful interpretation of the results information about deposition of aerosol particles in the respiratory tract is warranted, but not trivial to obtain for animals with nose...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Ahmed A,Prime D,Burnell PK,Högger P

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Understanding the regional partition of deposition of inhaled particles within the lung is important for improving targeted delivery of inhaled aerosolized drugs. One factor affecting regional deposition is gravity. As the lung deforms under its own weight, changes in lung volume, in airway geometries, and i...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Sá RC,Zeman KL,Bennett WD,Prisk GK,Darquenne C

更新日期：2015-12-01 00:00:00

abstract：: Background: Many substances used in inhalation research are water soluble and can be administered as nebulized solutions. Typical examples are therapeutic, small-molecular agents, or macromolecules. Another category is a number of water-soluble agents used for airway diagn...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Gerde P,Nowenwik M,Sjöberg CO,Selg E

更新日期：2020-04-01 00:00:00

abstract：: Background: Inhalation of medications is the cornerstone in the treatment of patients with lung diseases. A variety of inhalation devices exists and each device has specific requirements to achieve optimum inhalation of the drug. The goal of this study was to establish a c...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Pohlmann G,Hohlfeld JM,Haidl P,Pankalla J,Cloes RM

更新日期：2018-12-01 00:00:00

abstract：:The available toxicity data of benzalkonium chloride (BKC) clearly shows that it is toxic; however, the weight of evidence favors the view that at doses encountered in nasally and orally inhaled pharmaceutical preparations it is well tolerated. The adverse toxicological data predominantly come from in vitro and animal...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Johnson NF

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Particle size and velocity are two of the most significant factors that impact the deposition of pressurized metered-dose inhaler (pMDI) sprays in the mouth cavity. pMDIs are prominently used around the world in the treatment of patients suffering from a variety of lung diseases such as asthma and chronic ob...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Alatrash A,Matida E

更新日期：2016-12-01 00:00:00

abstract：:Antibiotic-resistant bacterial infections have renewed interest in finding substitute methods of treatment. The purpose of the present in vitro study was to investigate the possibility of respiratory delivery of a Burkholderia cepacia complex (BCC) bacteriophage by nebulized aerosol administration. Bacteriophages in i...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Golshahi L,Seed KD,Dennis JJ,Finlay WH

更新日期：2008-12-01 00:00:00

abstract：:The success of inhalation therapy is not only dependent upon the pharmacology of the drugs being inhaled but also upon the site and extent of deposition in the respiratory tract. Similarly, the toxicity of environmental and industrial particulate matter is affected not only by the nature of the dust but also by the am...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Darquenne C

更新日期：2020-08-01 00:00:00