Abstract：
BACKGROUND:Programmed cell death 4 (PDCD4), a protein that binds to eukaryotic initiation factor 4A (eIF4A), inhibits the initiation of translation. Although a number of tumor suppressors target transcription, Pdcd4 is the first suppressor targeting protein translation, and has also been suggested to function as a tumor suppressor gene in human cancer. The majority of tumor suppressors are mutationally inactivated, but the expression of Pdcd4 is downregulated with progression in a number of human cancer sites, including the lung. METHODS:An aerosol of lentivirus-shRNA Pdcd4 was delivered into A/J mice, through a nose-only inhalation system twice a week for 1 month. RESULTS AND CONCLUSIONS:Downregulated Pdcd4 resulted in increase levels of antiapoptotic and uPA-regulated proteins. We also found that downregulated Pdcd4 induced the mTOR/p70S6K pathway and cell-cycle proteins. Our results suggest that Pdcd4 may perform a critical function in the regulation of lung cancer cell proliferation.
journal_name
J Aerosol Med Pulm Drug Delivjournal_title
Journal of aerosol medicine and pulmonary drug deliveryauthors
Hwang SK,Minai-Tehrani A,Lim HT,Shin JY,An GH,Lee KH,Park KR,Kim YS,Beck GR Jr,Yang HS,Cho MHdoi
10.1089/jamp.2009.0778subject
Has Abstractpub_date
2010-10-01 00:00:00pages
285-93issue
5eissn
1941-2711issn
1941-2703journal_volume
23pub_type
杂志文章abstract：BACKGROUND:Inhaled corticosteroid (ICS) therapy has improved the quality of life (QOL) for many asthmatics and reduced mortality rates associated with asthma. However, some patients do not obtain therapeutic benefit despite satisfactory adherence. OBJECTIVES:To determine whether asthmatic patients were using ICS devic...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2010.0868
更新日期：2011-12-01 00:00:00
abstract：BACKGROUND:Currently bronchial provocation testing (BPT) using mannitol powder cannot be performed in children under 6 years. A primary reason is it is challenging for children at this age to generate a consistent inspiratory effort to inhale mannitol efficiently from a dry powder inhaler. A prototype system, which doe...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2015.1208
更新日期：2015-12-01 00:00:00
abstract：:Flexhaler is a multiple-dose, inspiratory flow-driven dry powder inhaler that is a newer version of Turbuhaler, and is identical to the Symbicort Turbuhaler. Sustained performance is of the utmost importance to ensure consistent drug delivery throughout the lifespan of the inhaler. We report functionality testing resu...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2008.0700
更新日期：2008-12-01 00:00:00
abstract：: Background: Many countries have introduced a compulsory use of community masks for certain public areas during the SARS-CoV-2 pandemic. Different manufacturers offer reusable community masks in large quantities. The efficacy of these masks, however, is unknown. ...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2020.1635
更新日期：2020-09-23 00:00:00
abstract：PURPOSE:Many methods have been developed to evaluate dry powder inhalation techniques and their efficiency for disease control in asthma patients. However, it is difficult to apply these methods to clinical practice and research. In this study, we introduce a simple new method that can be applied to dry powder inhalati...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2014.1193
更新日期：2016-10-01 00:00:00
abstract：BACKGROUND:The effectiveness of metered-dose inhalers (MDIs) in delivering medication to the lungs highly depends on its correct usage technique. Current guidelines state optimal technique for high lung deposition should include a slow inhalation (>5 seconds) at an inspiratory flow rate of 30 L/min and inhaler actuatio...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2015.1278
更新日期：2017-08-01 00:00:00
abstract：:Inhalation is a potentially viable route of administration for numerous agents. In diabetes mellitus, the need for frequent injections to achieve ideal glycemic control remains a significant limitation for initiating and complying with insulin therapy in a large number of patients. To overcome this barrier, inhaled in...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章,评审
doi：10.1089/jamp.2011.0876
更新日期：2011-10-01 00:00:00
abstract：PURPOSE:The objective of this study was to determine optimal aerosol delivery conditions for a full-term (3.6 kg) infant receiving invasive mechanical ventilation by evaluating the effects of aerosol particle size, a new wye connector, and timing of aerosol delivery. METHODS:In vitro experiments used a vibrating mesh ...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2013.1077
更新日期：2014-10-01 00:00:00
abstract：BACKGROUND:The delivery of antitubercular drugs through direct lung targeting can lead to reduction in the dose as well as side effects of the drug. In the present investigation, carrier (lactose)-based dry-powder inhaler of rifampicin was prepared to achieve direct targeting of the drug into the lungs. METHODS:The dr...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2017.1379
更新日期：2017-12-01 00:00:00
abstract：BACKGROUND:Secondary lung infections are the primary cause of morbidity associated with cystic fibrosis lung disease. Aerosolized antibiotic inhalation is potentially advantageous but has limited effectiveness due to altered airway aerodynamics and deposition patterns that limit drug access to infected regions. One pot...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2017.1412
更新日期：2018-08-01 00:00:00
abstract：: Background: Salvia miltiorrhiza polyphenolic acid (SMPA) is effective in the treatment of cardiovascular diseases and currently it is administered orally or intravenously. However, SMPA is poorly absorbed orally and quickly eliminated in vivo. A long-term frequent intraveno...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2019.1538
更新日期：2020-04-01 00:00:00
abstract：:Significant advances have been made in the last 50 years in developing safe and efficacious aerosol formulations for pulmonary delivery. The key to future innovation may lie at the interface between biology and particle engineering. Improved understanding of biological processes including particle clearance, cellular ...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章,评审
doi：10.1089/jamp.2010.0838
更新日期：2010-12-01 00:00:00
abstract：BACKGROUND:Predicting local lung tissue pharmacodynamic (PD) responses of inhaled drugs is a longstanding challenge related to the lack of experimental techniques to determine local free drug concentrations. This has prompted the use of physiologically based pharmacokinetic (PBPK) modeling to potentially predict local ...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2017.1436
更新日期：2019-02-01 00:00:00
abstract：BACKGROUND:Remote inhaler monitoring is an emerging technology that enables the healthcare team to monitor the time and location of a patient's inhaler use. We assessed the feasibility of remote inhaler monitoring for chronic obstructive pulmonary disease (COPD) patients and the pattern of albuterol inhaler use associa...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2017.1383
更新日期：2018-06-01 00:00:00
abstract：:The success of inhalation therapy is not only dependent upon the pharmacology of the drugs being inhaled but also upon the site and extent of deposition in the respiratory tract. Similarly, the toxicity of environmental and industrial particulate matter is affected not only by the nature of the dust but also by the am...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2020.29029.cd
更新日期：2020-08-01 00:00:00
abstract：BACKGROUND:Spiromax(®) is a novel dry powder inhaler for patients with asthma or chronic obstructive pulmonary disease (COPD). The studies presented here provide further data on attributes (in vitro dosing consistency with budesonide-formoterol (DuoResp) Spiromax; flow rates through empty versions of the Spiromax and T...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2015.1216
更新日期：2015-10-01 00:00:00
abstract：BACKGROUND:High flow nasal cannula oxygen therapy (HFT) is increasingly used in intensive and emergency care departments. Patients suffering from respiratory failure, who are likely to benefit from HFT, may require aerosolized bronchodilators; therefore, combining nebulization with HFT may be relevant. This study aimed...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2015.1219
更新日期：2016-04-01 00:00:00
abstract：:Upper respiratory tract infections (URTIs), primarily acute rhinopharyngitis, tonsillitis, adenoiditis, and rhinosinusitis (RS), are major causes of morbidity in both children and adults of any age. In addition to the frequent occurrence of related medical problems and the associated socioeconomic costs, URTIs have a ...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章,评审
doi：10.1089/jamp.2016.1300
更新日期：2017-02-01 00:00:00
abstract：BACKGROUND:Computer modeling is used to predict inhaled aerosol deposition in the lung based on definition of the aerosol characteristics and the breathing pattern and airway anatomy of the subject. Validation of the models is limited by the lack of detailed experimental data. Three-dimensional imaging provides an oppo...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2014.1191
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:The unit dose dry powder inhaler (UD-DPI) is being considered as an alternative inhaler platform that, if developed, has the potential to improve access to inhaled respiratory medicines in developing countries. AIM:This study compared the systemic exposure of fluticasone furoate after delivery from the UD-D...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章,随机对照试验
doi：10.1089/jamp.2016.1322
更新日期：2017-10-01 00:00:00
abstract：: Background: The photo reflection method (PRM) is used to measure light reflected from particles released from dry powder inhalers (DPIs). This simple method depicts time trajectories of released drugs; however, it underestimates the number of particles at high peak inhalat...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2020.1610
更新日期：2020-11-04 00:00:00
abstract：:Exhaled breath condensate (EBC) consists mainly of water, but also contains semivolatile and nonvolatile compounds. The aim of this study was to develop a system in which two condensers are simultaneously used in series to clarify the mechanisms of EBC condensation. Two aliquots of EBC (EBC1 and EBC2) were collected f...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2007.0644
更新日期：2008-03-01 00:00:00
abstract：BACKGROUND:To validate the 'Test of Adherence to Inhalers' (TAI), a 12-item questionnaire designed to assess the adherence to inhalers in patients with COPD or asthma. METHODS:A total of 1009 patients with asthma or COPD participated in a cross-sectional multicenter study. Patients with electronic adherence ≥80% were ...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章,多中心研究
doi：10.1089/jamp.2015.1212
更新日期：2016-04-01 00:00:00
abstract：BACKGROUND:Researchers, using checklists, have identified that 30%-90% of patients make errors in inhaler use. It is not certain whether these errors affect the delivery of medication. We have developed an electronic monitor (INCA™) that records audio each time an inhaler is used, providing objective information on inh...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2016.1334
更新日期：2017-08-01 00:00:00
abstract：:This article provides a concise review of the use of magnetic resonance imaging (MRI) for measurement of regional aerosol deposition in the lungs. Basic aspects of MRI and its use in lung imaging and measurement of regional ventilation are introduced. Imaging of hydrogen protons (water) and inhaled hyperpolarized gase...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章,评审
doi：10.1089/jamp.2011.0897
更新日期：2012-04-01 00:00:00
abstract：OBJECTIVES:This experimental study was conducted to determine the effects of training on inhaler technique and quality of life in patients with chronic obstructive pulmonary disease (COPD). METHODS:Among the patients who applied at the outpatient clinic of chest diseases between March 2009 and May 2010, a total of 69 ...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章,随机对照试验
doi：10.1089/jamp.2012.1017
更新日期：2013-12-01 00:00:00
abstract：BACKGROUND:Model predictions of regional deposition in the respiratory tract are useful in assessing factors that influence the effectiveness of aerosol delivery. Regional deposition models have previously been coupled with models of mucous production and clearance to estimate initial concentrations of drug deposited i...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2017.1377
更新日期：2018-02-01 00:00:00
abstract：BACKGROUND:Dyspnea significantly impacts quality of life and is one of the most common symptoms in advanced illness. Systemically-administered opioids and benzodiazepines have been the most studied and utilized pharmacologic treatments for refractory dyspnea. Less attention has been given to the use of these medication...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章,评审
doi：10.1089/jamp.2014.1136
更新日期：2015-02-01 00:00:00
abstract：:Since the early 1960s, there has been a continuous evolution in scientific understanding regarding bioequivalence (BE) of oral dosage forms, intermittently punctuated by some breakthrough research findings and conceptual advances. The accumulated knowledge from this body of research has been translated into a sophisti...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章,评审
doi：10.1089/jamp.2014.1144
更新日期：2014-12-01 00:00:00
abstract：:The use of gamma camera imaging following the inhalation of a radiolabel has been widely used by researchers to investigate the fate of inhaled aerosols. The application of two-dimensional (2D) planar gamma scintigraphy and single-photon emission computed tomography (SPECT) to the study of inhaled aerosols is discusse...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章,评审
doi：10.1089/jamp.2011.0960
更新日期：2013-06-01 00:00:00
