Abstract:
BACKGROUND AND PURPOSE:cerebral small vessel disease (SVD) is the most common cause of vascular dementia. Interest in the use of surrogate markers is increasing. The aims of this study were to determine if brain volume was different between patients with SVD and control subjects, whether it correlated with cognition in SVD, and whether changes in brain volume could be detected during prospective follow-up. METHODS:thirty-five patients (mean age, 68.8 years) who had a lacunar stroke and radiological evidence of confluent leukoaraiosis and 70 age- and gender-matched control subjects were recruited. Whole-brain T1-weighted imaging and neuropsychological testing were performed after 1 year on all patients and after 2 years for the control subjects. Fully automated software was used to determine brain volume and percentage brain volume change. An executive function score was derived. RESULTS:there was a significant difference in brain volume between the patients with SVD and control subjects (mean ± SD [mL] 1529 ± 84 versus 1573 ± 69, P=0.019). In the patients with SVD, there was a significant association between brain volume and executive function (r=0.501, P<0.05). The mean ± SD yearly brain atrophy rate for patients with SVD and control subjects was significantly different (-0.914% ± 0.8% versus -0.498% ± 0.4%, respectively, P=0.017). No change in executive function score was detected over this period. CONCLUSIONS:brain volume is reduced in SVD and a decline is detectable prospectively. The correlation with executive function at a cross-sectional level and the change in brain volume with time are both promising for the use of brain atrophy as a surrogate marker of SVD progression.
journal_name
Strokejournal_title
Strokeauthors
Nitkunan A,Lanfranconi S,Charlton RA,Barrick TR,Markus HSdoi
10.1161/STROKEAHA.110.594267subject
Has Abstractpub_date
2011-01-01 00:00:00pages
133-8issue
1eissn
0039-2499issn
1524-4628pii
STROKEAHA.110.594267journal_volume
42pub_type
杂志文章相关文献
STROKE文献大全abstract:BACKGROUND AND PURPOSE:There is increasing interest in defining stroke lesion volume thresholds to predict poststroke outcome. However, there is a paucity of data on factors that impact the association between critical infarct thresholds volume and outcome. We sought to determine whether lesion thresholds best predicti...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.116.013982
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Efforts to reduce disparities in recurrent stroke among Black and Latino stroke survivors have met with limited success. We aimed to determine the effect of peer education on secondary stroke prevention among predominantly minority stroke survivors. METHODS:Between 2009 and 2012, we enrolled 600...
journal_title:Stroke
pub_type: 杂志文章,随机对照试验
doi:10.1161/STROKEAHA.114.006623
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Patients with cerebral amyloid angiopathy (CAA) are at high risk for intracerebral hemorrhage (ICH), but no effective prevention strategies have been established. The objective is to determine whether lowering of blood pressure (BP) provides protection for this high-risk patient group. METHODS:T...
journal_title:Stroke
pub_type: 杂志文章,随机对照试验
doi:10.1161/STROKEAHA.109.563932
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Brain atrophy can be regarded as an end-organ effect of cumulative cardiovascular risk factors. Accelerated brain atrophy is described following ischemic stroke, but it is not known whether atrophy rates vary over the poststroke period. Examining rates of brain atrophy allows the identification o...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.120.030256
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Chronic kidney disease may increase the risk for ischemic stroke or systemic embolism in patients with nonvalular atrial fibrillation (AF). We conducted a meta-analysis to summarize all published studies to investigate the link between chronic kidney disease and risk of thromboembolic events in A...
journal_title:Stroke
pub_type: 杂志文章,meta分析
doi:10.1161/STROKEAHA.114.006881
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We demonstrated previously that treatment with selective kappa-opioid receptor (KOR) agonist BRL 52537 hydrochloride [(+/-)-1-(3,4-dichlorophenyl) acetyl-2-(1-pyrrolidinyl) methylpiperidine] (1) has a long therapeutic window for providing ischemic neuroprotection, and (2) attenuates ischemia-evok...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000169928.76321.3d
更新日期:2005-07-01 00:00:00
abstract::Arteriolar diameters and venular erythrocyte velocities in the small pial vessels on the surface of the cat brain were measured by TV methods during induced epileptic seizures through a cranial window. Grand mal seizures maximally dilated arterioles and increased venular erythrocyte velocity up to 400%. High positive ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.7.1.83
更新日期:1976-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The presence of known restriction fragment length polymorphisms in the apoprotein A-I-C-III gene cluster, which encodes their respective apoproteins, was investigated using the restriction enzymes Sac I and Pst I to determine the potential role of genetic variations for stroke risk in an American...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.23.9.1257
更新日期:1992-09-01 00:00:00
abstract:BACKGROUND:Diffusion-weighted imaging (DWI) is the most sensitive MR sequence in acute arterial ischemic stroke but has not yet been evaluated in venous cerebral ischemia. We describe a patient with DWI performed at the acute phase of a venous ischemic stroke. CASE DESCRIPTION:A rapid cerebral MRI including DWI and fa...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.29.12.2649
更新日期:1998-12-01 00:00:00
abstract::Choline concentration is rate limiting in the synthesis of acetylcholine. There is a negative arteriovenous difference for choline concentration across the brain, indicating the steady output of choline from this organ. Cerebral ischemia may increase extracellular choline concentration by interfering with its removal ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.20.1.92
更新日期:1989-01-01 00:00:00
abstract::Eighteen patients with recent ischemic stroke were compared with an equal number of matched controls. Standardized suspensions of red cells as well as of red and white cells were filtered in a new filtration apparatus capable of discriminating between cell deformability and filter occlusion. Results show that red cell...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.18.1.59
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Risk-factor modeling has been proposed to identify patients with carotid stenosis who will most benefit from surgery. Validation by independent institutions performing carotid endarterectomy is necessary to determine the applicability of such models to the individual patient. METHODS:A series of...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/01.str.0000051729.79990.fb
更新日期:2003-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Short-term elevations in fine particulate matter air pollution (PM2.5) are associated with increased risk of acute cerebrovascular events. Evidence from the peripheral circulation suggests that vascular dysfunction may be a central mechanism. However, the effects of PM2.5 on cerebrovascular funct...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.111.000395
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Stroke symptoms in the absence of recognized stroke are common, but potential associated dysfunctions have not been described. METHODS:We assessed quality-of-life measures using the Physical and Mental Component Summary scores of the Short Form 12 (PCS-12 and MCS-12) in the REasons for Geographi...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.106.478032
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Gender differences in carotid endarterectomy (CEA) rates after transient ischemic attack are not well studied, although some reports suggest that eligible men are more likely to have CEA than women after stroke. METHODS:We retrospectively identified all patients diagnosed with transient ischemic...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.580977
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:To date, few studies have examined associations between the wide range of flavonoid subclasses and risk of ischemic, hemorrhagic, and total stroke. METHODS:We conducted a prospective study among 69 622 women from the Nurses' Health Study. Total flavonoid and subclass intakes were calculated from...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/STROKEAHA.111.637835
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Transcatheter closure of patent foramen ovale (PFO) has been reported to improve migraine in patients with cerebrovascular disorders in noncontrolled studies. The aim of the study was to compare the course of migraine assessed prospectively over a 12-month period in symptomatic (for cerebrovascul...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000199082.07317.43
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Purinergic nucleoside inosine elicits protection and regeneration during various injuries. The purpose of this study was to examine the protective effects of inosine against cerebral ischemia. METHODS:Adult Sprague-Dawley rats were anesthetized. Inosine, hypoxathine, or vehicle was administered ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000155747.15679.04
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Neutrophil Extracellular Traps (NETs) are DNA extracellular networks decorated with histones and granular proteins produced by activated neutrophils. NETs have been identified as major triggers and structural factors of thrombosis. A recent study designated extracellular DNA threads from NETs as ...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/STROKEAHA.117.019896
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The apparent diffusion coefficient (ADC) of water should be sensitive to the cytotoxic edema triggered by energy failure during ischemia. Elevated values of T2. the nuclear MR transverse relaxation time of water, seen on T2 nuclear MR images detect vasogenic edema and infarcted areas. The tempora...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.28.2.419
更新日期:1997-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We evaluated the impact of admission hyperglycemia (HG) on stroke outcome in relation to the timing of reperfusion in patients treated with tissue plasminogen activator (tPA). METHODS:We studied 138 consecutive stroke patients with a documented middle cerebral artery (MCA) occlusion treated with...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000143728.45516.c6
更新日期:2004-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The inflammatory response within cerebral infarcts may have an influence on tissue damage. Since old animals with an impaired immune response have decreased inflammation after experimental cerebral infarction, we postulated that female animals with an increased immune response will have an increa...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.27.3.498
更新日期:1996-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Several studies have reported on the correlation of ultrasonic carotid plaque morphology, cerebrovascular symptoms, and intraplaque hemorrhage. This study correlates ultrasonic carotid plaque morphology with the degree of carotid stenosis. METHODS:Carotid arteries (n=2460) were examined by using...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.0000019127.11189.b5
更新日期:2002-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Transcranial Doppler (TCD) and carotid duplex (CD) provide rapid and safe screening for stroke patients but are highly operator dependent. We explored the feasibility of telemedicine (TM)-guided TCD/CD administered by a health care provider inexperienced with ultrasound. METHODS:Dual video scree...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000196988.45318.97
更新日期:2006-01-01 00:00:00
abstract::A standardized neurologic assessment scoring instrument was developed and tested for use in a multicenter trial of hypervolemic hemodilution in acute hemispheric stroke. Components of the neurologic examination pertinent to hemispheric stroke syndromes were emphasized. The scale was evaluated using 16 acute stroke pat...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.18.3.665
更新日期:1987-05-01 00:00:00
abstract::Spontaneous dissections of the extracranial internal carotid artery are diagnosed more frequently as their clinical and angiographic features are more widely recognized. Familial occurrence of spontaneous dissection of the internal carotid artery has not been previously reported. We describe the occurrence of this ent...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.18.1.246
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Limited data exist on the performance of the revised Framingham Stroke Risk Score (R-FSRS) and the R-FSRS in conjunction with nontraditional risk markers. We compared the R-FSRS, original FSRS, and the Pooled Cohort Equation for stroke prediction and assessed the improvement in discrimination by ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.117.018928
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Our objective was to study age-specific prevalence, computed tomographic (CT) characteristics, risk factors, and the prognostic influence on stroke outcome of silent infarction in acute stroke patients. METHODS:The study was prospective and community-based and included 801 acute stroke patients,...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.25.1.97
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The ABCD system was developed to predict early stroke risk after transient ischemic attack. Incorporation of brain imaging findings has been suggested, but reports have used inconsistent methods and been underpowered. We therefore performed an international, multicenter collaborative study of the...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.110.578971
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Subfebrile body temperature and fever in the first days after stroke are strongly associated with unfavorable outcome. A subgroup analysis of a previous trial suggested that early treatment with paracetamol may improve functional outcome in patients with acute stroke and a body temperature of ≥36...
journal_title:Stroke
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/STROKEAHA.116.015957
更新日期:2017-04-01 00:00:00