Abstract：
BACKGROUND:Epidemiologic studies on the association between metals and body mass index (BMI) have been cross-sectional and have demonstrated inconsistent associations. Our study prospectively examined whether metals measured at baseline were associated with later BMI. We considered metals individually and as joint exposure to pre-defined metal groupings. METHODS:We measured concentrations of 16 metals in toenails collected at baseline (2003-2009) in a subset of 1221 women from the Sister Study. We calculated BMI from height and weight reported on a follow-up questionnaire an average of 5.2 years (range = 3.5-8.3) after baseline. Multivariable linear regression was used to estimate β coefficients and 95% confidence intervals (CIs) for associations between BMI and individual metals (with estimates given per interquartile range (IQR) increase or in quartiles). Quantile g-computation was used to examine joint associations between groups of metals and BMI. Groups considered were (1) all metals combined, and metals classified as (2) non-essential or (3) essential. RESULTS:In individual metal models we found that, with the exception of cobalt, no single metal was strongly related to BMI. In our mixture analyses, a quartile increase in all non-essential metals was associated with higher BMI (β = 0.32; 95%CI: 0.00, 0.63 kg/m2), whereas essential metals were suggestively associated with lower BMI (β = -0.25; 95%CI: 0.58, 0.07 kg/m2). CONCLUSIONS:In this population of women who were, on average, overweight, essential metals were jointly associated with slightly healthier, lower BMI whereas non-essential metals were jointly associated with slightly higher, unhealthier BMI, after controlling for other health indicators and predictors of metals exposures.
journal_name
Environ Resjournal_title
Environmental researchauthors
Niehoff NM,Keil AP,O'Brien KM,Jackson BP,Karagas MR,Weinberg CR,White AJdoi
10.1016/j.envres.2020.109396subject
Has Abstractpub_date
2020-05-01 00:00:00pages
109396eissn
0013-9351issn
1096-0953pii
S0013-9351(20)30289-9journal_volume
184pub_type
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