Abstract:
:We examined biomarkers of selenium status (whole blood Se; serum Se; glutathione peroxidase activity) and thyroid status (concentrations and ratios of thyroxine, T4; tri-iodothyronine, T3; albumin) in polar bears to assess variations among cohorts, and relationships to circulating concentrations of contaminants. Concentrations of total mercury (Hg) in whole blood were similar among cohorts (prime aged males and females, older animals, ages≥16 years, and young animals, ages 1-5 years; 48.44±35. 81; p=0.253). Concentrations of sum of seven polychlorinated biphenyls (∑PCB7) in whole blood were greater in females (with and without cubs, 26.44±25.82 ng/g ww) and young (26.81±10.67 ng/g ww) compared to males (8.88±5.76 ng/g ww, p<0.001), and significantly related to reduced body condition scores (p<0.001). Concentrations of Se and albumin were significantly greater in males than females (whole blood Se, males, 42.34 pmol/g ww, females, 36.25±6.27 pmol/g ww, p=0.019; albumin, males, 4.34±0.34 g/dl, females, 4.10±0.29 g/dL, p=0.018). Glutathione peroxidase activity ranged from 109.1 to 207.8 mU/mg hemoglobin, but did not differ significantly by sex or age (p>0.08). Thyroid hormones were greater in females (solitary females and females with cubs) compared to males (p<0.001). Biomarkers of Se status and concentrations of T3 were significantly positively related to Hg in all prime aged polar bears (p<0.03). Albumin concentrations were significantly positively related to total TT4, and significantly negatively related to concentrations of ∑PCB7 (p<0.003). Total thyroxine (TT4) was significantly negatively associated with blood concentrations of ∑PCB7 in solitary females (p=0.045). These data suggest that female polar bears were more susceptible to changes in blood-based biomarkers of selenium and thyroid status than males. Further classifications of the physiologic states of polar bears and repeated measures of individuals over time are needed to accurately assess the biological impact of combined toxicant exposures.
journal_name
Environ Resjournal_title
Environmental researchauthors
Knott KK,Schenk P,Beyerlein S,Boyd D,Ylitalo GM,O'Hara TMdoi
10.1016/j.envres.2011.08.009subject
Has Abstractpub_date
2011-11-01 00:00:00pages
1124-36issue
8eissn
0013-9351issn
1096-0953pii
S0013-9351(11)00208-8journal_volume
111pub_type
杂志文章abstract:BACKGROUND:Drinking water (DW) is an important dietary source of magnesium. Recently, Israel has increased its use of desalinated seawater (DSW) as DW country-wide. Its negligible magnesium content, however, raises concern that consumption of DSW may be associated with hypomagnesemia and increase the risk of ischemic h...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2018.06.053
更新日期:2018-10-01 00:00:00
abstract::Wastewaters serve as important hot spots for antimicrobial resistance and monitoring can be used to analyse the abundance and diversity of antimicrobial resistance genes at the level of large bacterial and human populations. In this study, whole genome sequencing of beta-lactamase-producing Escherichia coli and metage...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2020.110487
更新日期:2021-02-01 00:00:00
abstract::We examined changes in ambient dust lead (Pb) levels associated with the demolition of older row houses containing lead paint in Baltimore, MD, USA. Our previous paper describes the three study sites, the demolition processes, and increases in the Pb dustfall rate during demolition (>40-fold) and debris removal (>6-fo...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2004.10.005
更新日期:2005-10-01 00:00:00
abstract::Human biomonitoring data provide evidence to exposure of environmental chemicals. Physiologically based pharmacokinetic (PBPK) modelling together with an adequate exposure scenario allows to transpose measured concentrations of chemicals or their metabolites into exposure levels, as daily intakes. In France, high leve...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2020.110281
更新日期:2021-01-01 00:00:00
abstract::Epidemiological and clinical studies suggest that inhalation of cobalt metal dust (Co) mixed with tungsten carbide particles (WC), but not of cobalt dust alone, may cause interstitial pulmonary lesions (hard metal disease). In previous experimental studies in the rat, we have demonstrated the greater acute pulmonary t...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1006/enrs.1995.1032
更新日期:1995-05-01 00:00:00
abstract::Few studies investigate the impact of air pollution on the leading cause of infant morbidity, acute bronchiolitis. We investigated the influence of PM(2.5) and other metrics of traffic-derived air pollution exposure using a matched case-control dataset derived from 1997 to 2003 birth and infant hospitalization records...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2008.11.006
更新日期:2009-04-01 00:00:00
abstract::Daily emergency room (ER) visits for all respiratory (ICD-9 460-519) and asthma (ICD-9 493) were compared with daily sulfur dioxide (SO2), ozone (O3), and weather variables over the period 1998-2000 in Portland, Maine (population 248,000), and 1996-2000 in Manchester, New Hampshire (population 176,000). Seasonal varia...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2004.07.010
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND:According to the WHO, low birth weight (<2500 gr) is a primary maternal health indicator as the cause of multiple morbi-mortality in the short and long-term. It is known that air pollution from road traffic (PM10, NO2) and O3 have an important impact on low birth weight (LBW), but there are few studies of th...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2019.01.030
更新日期:2019-04-01 00:00:00
abstract::The practice of burning sugarcane obtained by non-mechanized harvesting exposes workers and the people of neighboring towns to high concentrations of particulate matter (PM) that is harmful to health, and may trigger a series of cardiorespiratory diseases. The aim of this study was to analyze the chemical composition ...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2014.07.030
更新日期:2014-11-01 00:00:00
abstract::This study examines the relationship between road traffic noise, self-reported sleep quality and mental health. The study is cross-sectional and based on data from a survey conducted in Oslo, Norway, in 2000. Psychological distress (Hopkins Symptom Checklist, HSCL-25) was measured along with self-reported somatic heal...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2014.02.010
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:Healthcare workers (HCWs) are highly exposed to SARS-CoV-2 infection given their specific tasks. The IgG-IgM serological assay has demonstrated good accuracy in early detection in symptomatic patients, but its role in the diagnosis of asymptomatic patients is uncertain. The aim of our study was to assess IgM...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2021.110793
更新日期:2021-01-25 00:00:00
abstract::Environmental exposure to manganese (Mn) results in several toxic effects, mainly neurotoxicity. This study investigated associations among Mn exposure, neuropsychological performance, biomarkers of oxidative damage and early kidney dysfunction in children aged 6-12 years old. Sixty-three children were enrolled in thi...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2016.01.035
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:Age at female puberty is associated with adult morbidities, including breast cancer and diabetes. Hormonally active chemicals are suspected of altering pubertal timing. We examined whether persistent organic pollutants (POPs) are associated with age at menarche in a longitudinal study. METHODS:We analyzed d...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2019.108551
更新日期:2019-09-01 00:00:00
abstract::This study aims to remove organic cationic dye Basic Fuchsin (BF) by adsorption onto a low cost eggshell membrane (ESM) in batch mode at 293 K. XRD analysis confirms the amorphous nature of ESM meanwhile FTIR spectroscopy reveals the presence of several functional groups such as hydroxyl (-OH), sulfhydryl (-SH), carbo...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2020.109484
更新日期:2020-07-01 00:00:00
abstract::We examined relationships between trace metal concentrations in tissues of common eider ducks (cadmium, mercury, and selenium) and selected biomarkers of health (stress response, immune function, and body condition). This study was conducted at an eider nesting colony in the Canadian arctic in 1998 and 1999. Capture-i...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1006/enrs.2002.4384
更新日期:2002-09-01 00:00:00
abstract::Studies have suggested an association between maternal exposure to ambient air pollution and risk of congenital anomaly. The aim of this study is to investigate the association between exposure to black smoke (BS; particulate matter with aerodynamic diameter <4 microg/m(3)) and sulphur dioxide (SO(2)) during the first...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2008.11.007
更新日期:2009-02-01 00:00:00
abstract::Natural-occurring minerals representative of six silicate classes were examined for their influence on interferon induction by influenza virus in Rhesus monkey kidney (LLC-MK2) cell monolayers. Minerals within the classes nesosilicate, sorosilicate, cyclosilicate, and inosilicate exhibited either little or marked (50%...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/s0013-9351(87)80040-3
更新日期:1987-08-01 00:00:00
abstract::Research that analyzes the effect of different environmental factors on the impact of COVID-19 focus primarily on meteorological variables such as humidity and temperature or on air pollution variables. However, noise pollution is also a relevant environmental factor that contributes to the worsening of chronic cardio...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2021.110766
更新日期:2021-01-23 00:00:00
abstract::Ciguatera fish poisoning (CFP) is one of the most devastating food-borne illnesses caused by fish consumption. Ciguatoxins (CTXs) are potent neurotoxins synthesized by the benthic microalgae Gambierdiscus spp. and Fukuyoa spp. that are transmitted to fish by grazing and predation. Despite the high incidence of CFP, af...
journal_title:Environmental research
pub_type: 杂志文章,评审
doi:10.1016/j.envres.2020.109111
更新日期:2020-03-01 00:00:00
abstract::Studies of heat-related mortality have been predominantly based on analyses of underlying cause of death as the single indicator of a population's vulnerability to high temperatures. Examination of both underlying and associated causes of death could provide a more comprehensive understanding of the population at risk...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2008.07.015
更新日期:2008-11-01 00:00:00
abstract::In recent years, Solea senegalensis has increasingly been used in pollution monitoring studies. In order to assess its response to some particular widespread pollutants, juveniles of S. senegalensis were administered an intraperitoneal injection of the model aryl hydrocarbon receptor agonist β-naphtoflavone (βNF) and ...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2014.09.024
更新日期:2014-11-01 00:00:00
abstract::Over the past 20 years lead has been proven to exert an influence on the intelligence of children. Especially for children exposed to environmental lead, average blood lead was often lower than the officially recognized intoxication level. Because Kaohsiung is an industrial area in Taiwan and lead exposure is an impor...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1006/enrs.2002.4342
更新日期:2002-05-01 00:00:00
abstract:BACKGROUND:Prenatal phthalate exposure has been associated with behavioral problems and lower performance on measures of cognitive ability in children. However, the potential effect of phthalate exposure during the sensitive preconception period is unknown. OBJECTIVES:To estimate the association of maternal and patern...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2017.07.032
更新日期:2017-10-01 00:00:00
abstract::An iterative scheme of short-term bacterial mutagenesis assays and multidimensional liquid chromatographic methods was used to isolate mutagens from a neutral fraction of a complex carcinogenic tar formed as a by-product of coal gasification. Mutagens in the complementary reversed- and normal-phase liquid chromatograp...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/s0013-9351(86)80135-9
更新日期:1986-12-01 00:00:00
abstract::There is only limited monitoring data of black carbon for epidemiologic analyses. In the current study, we used the distributed lag models to evaluate the association between mortality outcomes (both total and cause-specific) and exposure to black carbon and fine particle (PM(2.5)) in Shanghai, China. During our resea...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2012.08.007
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Few studies have examined temperature's effect on adverse birth outcomes and relevant effect modifiers. OBJECTIVES:We investigated associations between heat and adverse birth outcomes and how individual and community characteristics affect these associations for Seoul, Korea, 2004-2012. METHODS:We applied ...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2018.10.032
更新日期:2019-01-01 00:00:00
abstract::The effect of chronic exposure to 2 ppm nitrogen dioxide (NO2) for 8 hr a day, 5 days a week, for 8 weeks was assessed in normal and emphysematous hamsters by measuring (1) lung morphometry (mean linear intercept [Lm] and internal surface area [ISA]), (2) lung mechanics (lung volume, compliance and coefficient of stat...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/s0013-9351(87)80059-2
更新日期:1987-06-01 00:00:00
abstract::There are very few metabolomics assessments based on field accumulated, uncontrolled contaminant exposures in wildlife, particularly in the Arctic. In the present study, targeted metabolomics and contaminant data were analyzed together to assess potential influences of contaminant exposure on the hepatic metabolome of...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2018.10.001
更新日期:2019-01-01 00:00:00
abstract::Several studies have demonstrated that millions of people globally are potentially exposed to volcanic gases. Hydrogen sulfide is a typical gas in volcanic and geothermal areas. The gas is toxic at high concentrations that predominantly affects the nervous, cardiovascular, and respiratory systems. The WHO air quality ...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2010.05.009
更新日期:2010-08-01 00:00:00
abstract::Three groups of rats were given sodium selenite (Se), sodium selenite and cadmium chloride (Se + Cd), or sodium selenite, cadmium chloride, and mercuric chloride (Se + Cd + Hg), respectively. All animals received subcutaneous doses of 115CdCl2 (0.3 mg Cd/kg) every other day for a fortnight. Mercuric chloride was admin...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/0013-9351(83)90004-x
更新日期:1983-08-01 00:00:00