Abstract:
:Environmental exposure to manganese (Mn) results in several toxic effects, mainly neurotoxicity. This study investigated associations among Mn exposure, neuropsychological performance, biomarkers of oxidative damage and early kidney dysfunction in children aged 6-12 years old. Sixty-three children were enrolled in this study, being 43 from a rural area and 20 from an urban area. Manganese was quantified in blood (B-Mn), hair (H-Mn) and drinking water using inductively coupled plasma mass spectrometry (ICP-MS). The neuropsychological functions assessed were attention, perception, working memory, phonological awareness and executive functions - inhibition. The Intelligence quotient (IQ) was also evaluated. The biomarkers malondialdehyde (MDA), protein carbonyls (PCO), δ-aminolevulinate dehydratase (ALA-D), reactivation indexes with dithiothreitol (ALA-RE/DTT) and ZnCl2 (ALA-RE/ZnCl2), non-protein thiol groups, as well as microalbuminuria (mALB) level and N-acetyl-β-D-glucosaminidase (NAG) activity were assessed. The results demonstrated that Mn levels in blood, hair and drinking water were higher in rural children than in urban children (p<0.01). Adjusted for potential confounding factors, IQ, age, gender and parents' education, significant associations were observed mainly between B-Mn and visual attention (β=0.649; p<0.001). Moreover, B-Mn was negatively associated with visual perception and phonological awareness. H-Mn was inversely associated with working memory, and Mn levels from drinking water with written language and executive functions - inhibition. Rural children showed a significant increase in oxidative damage to proteins and lipids, as well as alteration in kidney function biomarkers (p<0.05). Moreover, significant associations were found between B-Mn, H-Mn and Mn levels in drinking water and biomarkers of oxidative damage and kidney function, besides between some oxidative stress biomarkers and neuropsychological tasks (p<0.05). The findings of this study suggest an important association between environmental exposure to Mn and toxic effects on neuropsychological function, oxidative damage and kidney function in children.
journal_name
Environ Resjournal_title
Environmental researchauthors
Nascimento S,Baierle M,Göethel G,Barth A,Brucker N,Charão M,Sauer E,Gauer B,Arbo MD,Altknecht L,Jager M,Dias AC,de Salles JF,Saint' Pierre T,Gioda A,Moresco R,Garcia SCdoi
10.1016/j.envres.2016.01.035subject
Has Abstractpub_date
2016-05-01 00:00:00pages
32-43eissn
0013-9351issn
1096-0953pii
S0013-9351(16)30033-0journal_volume
147pub_type
杂志文章abstract::Pesticides, despite their known toxicity, are widely used in developing countries. Evaluating the pattern of their use would be interesting to assess the appropriateness of adequate intervention. Using a standardized questionnaire, a knowledge, attitude, and practice study was performed in two Lebanese regions, in whi...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/s0013-9351(03)00092-6
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:In previous studies investigating the short-term health effects of ambient air pollution the exposure metric that is often used is the daily average across monitors, thus assuming that all individuals have the same daily exposure. Studies that incorporate space-time exposures of individuals are essential to ...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2017.03.017
更新日期:2017-07-01 00:00:00
abstract::Human nail clippings have been used in recent epidemiological studies as a routine bioindicator of arsenic and selenium exposure. To ensure sound application of this biomarker, however, it is important to consider properties and scientific knowledge pertaining to validation of this particular tool. In this review, the...
journal_title:Environmental research
pub_type: 杂志文章,评审
doi:10.1016/j.envres.2005.12.001
更新日期:2006-09-01 00:00:00
abstract::Athens is a city with a serious air pollution problem which has existed for more than 20 years. To evaluate whether air pollution has affected lung cancer incidence (and hence, mortality) in the population of Athens we have compared standardized lung mortality between Athens and the rest of Greece taking into account ...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/s0013-9351(87)80225-6
更新日期:1987-12-01 00:00:00
abstract:BACKGROUND:Endocrine disrupting industrial chemicals, such as polychlorinated biphenyls (PCBs), are suspected to adversely affect male reproductive functions. OBJECTIVES:The Faroe Islands community exhibits an unusually wide range of exposures to dietary contaminants, and in this setting we examined the possible assoc...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2015.02.030
更新日期:2015-04-01 00:00:00
abstract:CONTEXT AND OBJECTIVE:Asthma among children is a major public health problem worldwide. There are increasing number of studies suggesting a possible association between allergenic pollen and exacerbations of asthma. In the context of global climate change, a number of future climate and air pollution scenarios predict ...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2007.10.005
更新日期:2008-02-01 00:00:00
abstract::Quantification of dermal absorption of volatile organic chemicals (VOCs) from aqueous solutions is required to understand the potential health hazards resulting from skin exposure to these chemicals in contaminated water. Male Fischer 344 rats were dermally exposed (3.1-cm2 dorsal skin) to neat, one-third saturated, t...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/s0013-9351(05)80140-9
更新日期:1991-06-01 00:00:00
abstract::Lead exposure during pregnancy remains a public health problem with potential lifelong impacts on children's growth and development. Mexico is unique in that stunting and obesity are both major public health concerns in children. This situation might be exacerbated by lead exposure which remains more common in Mexico ...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2016.10.014
更新日期:2017-01-01 00:00:00
abstract::In whole animals, ozone acutely impairs pulmonary function, an effect which may be mediated by eicosanoids. This study determined if the lung itself, separated from blood components and the CNS, responds to ozone with increased eicosanoid production and decreased function. Wistar rat lungs were placed in a negatively ...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1006/enrs.1994.1054
更新日期:1994-08-01 00:00:00
abstract:OBJECTIVE:To study pregnancy outcome including development of childhood cancer in areas within Sweden with the highest radioactive fallout after the Chernobyl accident in 1986. METHODS:Various Swedish health registries were used in order to identify all pregnancies and their outcome in Sweden according to the measured...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1006/enrs.1994.1070
更新日期:1994-11-01 00:00:00
abstract::In May 2000, the Agency for Toxic Substances and Disease Registry of the US government conducted a health investigation in response to community concerns regarding ambient and indoor hydrogen sulfide (H(2)S), odor, and health symptoms in Dakota City, Nebraska. The objective was to determine whether adult residents in ...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2003.08.005
更新日期:2004-05-01 00:00:00
abstract::We assessed the association between blood methylmercury (MeHg) and cognitive function in 240 adult residents living near a deserted chloralkali plant. Total mercury (T-Hg) in the blood, MeHg, and health and dietary related questionnaire were examined for all participants. The Cognitive Abilities Screening Instrument (...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2008.06.006
更新日期:2008-11-01 00:00:00
abstract::Research that analyzes the effect of different environmental factors on the impact of COVID-19 focus primarily on meteorological variables such as humidity and temperature or on air pollution variables. However, noise pollution is also a relevant environmental factor that contributes to the worsening of chronic cardio...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2021.110766
更新日期:2021-01-23 00:00:00
abstract::Industrially produced chemicals have been a major environmental concern across our entire Globe since the onset of rapid industrial development around the early 1900. Many of the substances being used are known to be endocrine disrupting chemicals (EDCs) and are also known to be long-range dispersed and to biomagnify ...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2014.12.026
更新日期:2015-02-01 00:00:00
abstract::Environmental phenols are a group of chemicals with widespread uses in consumer and personal care products, food and beverage processing, and in pesticides. We assessed exposure to benzophenone-3, bisphenol A (BPA), triclosan, methyl- and propyl parabens, and 2,4- and 2,5-dichlorophenol or their precursors in 506 preg...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2013.12.004
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:Both traffic-related noise and air pollution have been associated with cardiovascular disease (CVD). Spatial correlations between these environmental stressors may entail mutual confounding in epidemiological studies investigating their long-term effects. Few studies have investigated their correlation - non...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2010.10.013
更新日期:2011-01-01 00:00:00
abstract::Pleural calcifications are described in 122 of 268 (45.5%) inhabitants of four villages (Metsovo, Anilio, Milea, and Votonosi) in a small area of northwestern Greece (total population about 5000). All affected individuals are of one ethnic group, Vlachi. Calcifications were not noted in any of the 103 persons in the c...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/0013-9351(85)90096-9
更新日期:1985-12-01 00:00:00
abstract::To know the short- as well as long-term effect of aqueous latex extracts of Euphorbia tirucalli on carbohydrate and protein metabolism, the snail Lymnaea acuminata was exposed to sublethal doses of 0.37 and 0.55 mg/L for a 24-h and 0.20 and 0.31 mg/L for a 96-h exposure period. Significant (P<0.05) alterations in the ...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2004.12.008
更新日期:2005-11-01 00:00:00
abstract::Vintages of French wine from 1950 to 1991 were analyzed for lead isotopes and concentrations to investigate whether they might be used to archive the isotopic composition of the anthropogenic lead in aerosols to which the vineyard was exposed. Early vintages (1950-1980) contained 78-227 ng/g of lead with 206Pb/207Pb r...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1006/enrs.1997.3812
更新日期:1998-08-01 00:00:00
abstract::Paraquat is known to produce hyperglycemia in rodents, although the mechanisms responsible for the hyperglycemic effect of paraquat are not clearly understood. In this study we report the effects of paraquat (25 mg/kg iv) on plasma glucose, cortisol, catecholamines, and insulin in dogs. Paraquat caused a significant i...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/0013-9351(83)90169-x
更新日期:1983-02-01 00:00:00
abstract::Urinary β2-microgroblin (β2-MG) excretion levels above 300 μg/g creatinine are used to indicate defective tubular reabsorption. Arguably, increased urinary β2-MG excretion could also reflect glomerular filtration rate decline. Thus, we investigated an association between urinary β2-MG and estimated glomerular filtrati...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2019.03.026
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Prenatal phthalate exposure has been associated with behavioral problems and lower performance on measures of cognitive ability in children. However, the potential effect of phthalate exposure during the sensitive preconception period is unknown. OBJECTIVES:To estimate the association of maternal and patern...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2017.07.032
更新日期:2017-10-01 00:00:00
abstract::Penicillic acid (PA) is a polyketide mycotoxin produced by several species of Aspergillus and Penicillium. This mycotoxin is toxic in experimental animals and has also been reported to be carcinogenic. The cytotoxicity of penicillic acid was studied in rat alveolar macrophages (AM) in vitro. The effects of penicillic ...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/s0013-9351(86)80145-1
更新日期:1986-12-01 00:00:00
abstract::The growing human population concentrated in urban areas lead to the increase of road traffic and artificial areas, consequently enhancing air pollution and urban heat island effects, among others. These environmental changes affect citizen's health, causing a high number of premature deaths, with considerable social ...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2017.10.006
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Traffic-related air pollution (TRAP) exposure has been linked to type 2 diabetes and metabolic dysfunction in humans. Animal studies suggest that air pollutants may alter the composition of the gut microbiota, which may negatively impact metabolic health through changes in the composition and/or function of ...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2017.11.046
更新日期:2018-02-01 00:00:00
abstract::Variation in individual susceptibility to arsenic-induced disease may be partially explained by genetic differences in arsenic metabolism. Mounting epidemiological evidence and in vitro studies suggest that methylated arsenic metabolites, particularly monomethylarsonic (MMA3), are more acutely toxic than inorganic ars...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2010.05.001
更新日期:2010-08-01 00:00:00
abstract::Polychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants that disrupt thyroid hormone (TH) system function in numerous species. Previous studies have shown delayed metamorphosis in developing Xenopus laevis frogs exposed to PCBs, but the underlying molecular mechanisms have not been thoroughly invest...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2006.04.001
更新日期:2006-10-01 00:00:00
abstract:BACKGROUND:Ambient fine particulate matter (PM2.5) is associated with a wide range of acute and chronic health effects, including increased risk of respiratory infection. However, evidence specifically related to novel coronavirus disease (COVID-19) is limited. METHODS:COVID-19 case counts for 111 Canadian health regi...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2020.110052
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVE:To assess the relationship between in utero and concurrent child urinary exposures to bisphenol A (BPA) and phthalates with BMI z-score, waist circumference, and sum of triceps and subscapular skinfold thickness in Mexican children. METHODS:Among participants (N=249) from the Early Life Exposure in Mexico to...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2017.03.038
更新日期:2017-07-01 00:00:00
abstract::Cytogenetic investigations were carried out on 50 workers exposed to stone dust in a stone crusher industry and on 25 control subjects never exposed to such dust. The frequency of chromosomal aberrations and sister chromatid exchanges in exposed individuals was significantly higher than that in controls (P less than 0...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/s0013-9351(05)80106-9
更新日期:1991-10-01 00:00:00