Abstract:
:Paraquat is known to produce hyperglycemia in rodents, although the mechanisms responsible for the hyperglycemic effect of paraquat are not clearly understood. In this study we report the effects of paraquat (25 mg/kg iv) on plasma glucose, cortisol, catecholamines, and insulin in dogs. Paraquat caused a significant increase in plasma glucose level at all times of measurement except at 0.5 hr following paraquat administration. The cortisol levels after paraquat treatment were increased to 133, 305, 279, 418, 517, 672, and 567% above zero time control at 0.5, 1.5, 3, 6, 12, and 24 hr, and at death time respectively. The catecholamines at these times were increased to 42, 17, 72, 118, 138, 226, and 435% above the control. In contrast to cortisol and catecholamines, the plasma insulin levels after paraquat treatment were significantly decreased at 3, 6, 12, and 24 hr. These hormonal observations can explain, at least in part, the observed hyperglycemia, since all promote hyperglycemic states. For example, cortisol is gluconeogenic, catecholamines are glycogenolytic, and lower insulin levels result in depressed peripheral glucose utilization.
journal_name
Environ Resjournal_title
Environmental researchauthors
Giri SN,Curry DL,Stabenfeldt G,Spangler WL,Chandler DB,Schiedt MJdoi
10.1016/0013-9351(83)90169-xsubject
Has Abstractpub_date
1983-02-01 00:00:00pages
80-8issue
1eissn
0013-9351issn
1096-0953pii
0013-9351(83)90169-Xjournal_volume
30pub_type
杂志文章abstract::Chitosan was used as crosslinking agent to load bimetal particles onto bentonite. The Fe-Al bimetal chitosan bentonite (Fe-Al bimetal @ bent) complex was prepared for the efficient removal of nitrate from wastewater and its by-products at low temperature. The samples were characterized by Scanning electron microscope ...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2020.109336
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:Exposure to ubiquitous polycyclic aromatic hydrocarbons (PAHs) has been associated with decreased heart rate variability (HRV). Evidence accumulates that microRNAs (miRNAs) might be the intermediate factors between environmental exposures and their adverse health effects. Single nucleotide polymorphisms (SNP...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2016.04.014
更新日期:2016-07-01 00:00:00
abstract::Radon (222Rn) concentrations in 26 ground water wells of two distinct lithologies in the Piedmont of Virginia were measured to assess variation in ground water radon concentrations (GWRC), to evaluate differences in concentrations related to well characteristics, lithology, and spatial distributions, and to assess the...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2006.02.002
更新日期:2006-07-01 00:00:00
abstract::Riverine populations of the Brazilian Amazon depend on fish for their principal source of protein, which changes in availability with seasonal fluctuations in the aquatic ecosystem. We report seasonal (high and low waters) and interannual changes in total mercury and methylmercury concentrations in hair of subsistence...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2010.07.008
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:Micronuclei (MNs) are extranuclear DNA-containing bodies and determining MN frequencies is a measure of genomic instability. An age-related increase in MN frequencies in lymphocytes has been quantified, but this effect has not yet been measured in nasal and buccal cells. METHODS:We determined the effect of ...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2019.108824
更新日期:2020-01-01 00:00:00
abstract:INTRODUCTION:The prevalence of asthma and allergy has increased among children. This increase in prevalence might be related to dietary patterns. AIMS:The present epidemiological study investigated the relationship between the consumption of fruit, vegetables, nuts, meat and fish, and the prevalence of wheeze, asthma,...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2017.08.020
更新日期:2017-11-01 00:00:00
abstract:INTRODUCTION:Childhood obesity is one of the most serious public health challenges of our times. Although an important body of experimental evidence highlights the obesogenic potential of endocrine disruptors such as bisphenol A (BPA), the epidemiological evidence remains inconclusive and limited. OBJECTIVE:To assess ...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2019.03.045
更新日期:2019-06-01 00:00:00
abstract::Catalytic co-pyrolysis (CCP) of spent coffee ground (SCG) and cellulose over HZSM-5 and HY was characterized thermogravimetrically, and a catalytic pyrolysis of two samples was conducted using a tandem micro reactor that directly connected with gas chromatography-mass spectrometry. To access the more fundamental inves...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2020.109311
更新日期:2020-05-01 00:00:00
abstract::The objective of the study was to determine the relationship between cadmium (Cd) intake and cadmium toxicity indicators by meta-analysis of literature data, in particular beta2-microglobulin (beta2MC), and to compare the results with the current Provisional Tolerable Weekly Intake (PTWI) set by FAO/WHO. The literatur...
journal_title:Environmental research
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.envres.2006.09.006
更新日期:2007-03-01 00:00:00
abstract::A functional observational battery (FOB) with modified objective gait analysis was validated using the neurotoxicants acrylamide and methanol. The FOB consisted of side cage observation (30 sec); open field observation (2 min); evaluation of handling, reflexes, and gait scoring; and grip strength of the fore limbs and...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1006/enrs.1997.3718
更新日期:1997-01-01 00:00:00
abstract::We analyzed the exogenous mineral particle concentration, size, type, and distribution for particles larger than 0.1 micron in the left lungs of 10 long-term male cigarette smokers. The mean number of particles found was 465 +/- 295 X 10(6)/g dry lung, of which 80% were kaolinite, micas, feldspars, free silica, and ta...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/s0013-9351(87)80013-0
更新日期:1987-02-01 00:00:00
abstract::The effect of chronic exposure to 2 ppm nitrogen dioxide (NO2) for 8 hr a day, 5 days a week, for 8 weeks was assessed in normal and emphysematous hamsters by measuring (1) lung morphometry (mean linear intercept [Lm] and internal surface area [ISA]), (2) lung mechanics (lung volume, compliance and coefficient of stat...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/s0013-9351(87)80059-2
更新日期:1987-06-01 00:00:00
abstract:BACKGROUND:Exposure to fine particles in the atmosphere can adversely affect health and even lead to premature death. Recently, South Korea has attracted attention because of its rapid increase in the concentration of Particulate Matter (PM). OBJECTIVES:We estimated the economic benefits of reducing PM10 in Seoul, Sou...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2019.03.042
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Delayed central conduction times in the auditory brainstem have been observed in Mexico City (MC) healthy children exposed to fine particulate matter (PM2.5) and ozone (O3) above the current United States Environmental Protection Agency (US-EPA) standards. MC children have α synuclein brainstem accumulation ...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2017.06.026
更新日期:2017-10-01 00:00:00
abstract::We investigated the level of five non-essential metal(loid)s (As, Cd, Hg, Tl, Pb) and nine essential metals (Mg, Ca, Mn, Fe, Co, Cu, Zn, Se, Mo) in hair and blood components of captive and free-ranging European brown bear populations in Croatia and Poland. Metal(loid) associations with biomarkers of oxidative stress (...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2020.109166
更新日期:2020-04-01 00:00:00
abstract::Eight rabbits were exposed to 0.7 +/- 0.4 mg/m3 Co2+ as CoCl2 and 1.2 +/- 0.7 mg/m3 Cr3+ as Cr(NO3)3 (group Co + Cr), eight to 0.6 +/- 0.5 mg/m3 Co2+ (group Co), and eight to filtered air (control group), for 4 months, 5 days/week, and 6 hr/day. All rabbits in group Co + Cr and group Co showed nodular aggregation of a...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/s0013-9351(05)80206-3
更新日期:1992-06-01 00:00:00
abstract::On May 24-25, 2005 in Ann Arbor, Michigan, the US Environmental Protection Agency, the National Institute of Environmental Health Sciences, and the University of Michigan sponsored a technical workshop on the topic of connecting social and environmental factors to measure and track environmental health disparities. Th...
journal_title:Environmental research
pub_type:
doi:10.1016/j.envres.2005.11.001
更新日期:2006-10-01 00:00:00
abstract::Inhalation of particulate matter (PM) has been linked to serious adverse health effects, such as asthma, cardiovascular diseases and lung cancer. In the present study, coarse (PM10-2.5), accumulation mode (PM2.5-0.25), and quasi-ultrafine (PM0.25) particulates were collected inside twelve educative centers of Tarragon...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2019.05.035
更新日期:2019-08-01 00:00:00
abstract::Our study investigated a large variety of per- and polyfluoroalkyl substances (PFASs) in house dust collected from Guangzhou, South China during 2015-2018. The perfluorobutane sulfonic acid (PFBS) exhibited the highest median concentration (17.6 ng/g), followed by linear perfluorooctanoic acid (L-PFOA; 4.8 ng/g), line...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2020.110243
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Children are sensitive to indoor environmental pollution. Up until now there has been a lack of data on air quality in child day care centers. OBJECTIVES:The aim of this study is to document the indoor environment quality of Paris child day care centers by repeated measurements, and to compare pollutant lev...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2011.06.009
更新日期:2011-11-01 00:00:00
abstract::Industrially produced chemicals have been a major environmental concern across our entire Globe since the onset of rapid industrial development around the early 1900. Many of the substances being used are known to be endocrine disrupting chemicals (EDCs) and are also known to be long-range dispersed and to biomagnify ...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2014.12.026
更新日期:2015-02-01 00:00:00
abstract::Lead exposure is still a national concern, and it is possible that Native Americans who live on reservations and pursue traditional lifestyles may be at higher risk through both their unique exposure profiles and their potentially greater sensitivity. A major component of the exposure assessment is the diet. For triba...
journal_title:Environmental research
pub_type: 杂志文章,评审
doi:10.1006/enrs.2001.4250
更新日期:2001-06-01 00:00:00
abstract::Studies of heat-related mortality have been predominantly based on analyses of underlying cause of death as the single indicator of a population's vulnerability to high temperatures. Examination of both underlying and associated causes of death could provide a more comprehensive understanding of the population at risk...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2008.07.015
更新日期:2008-11-01 00:00:00
abstract::These studies evaluated symptom and pulmonary function responses of humans sequentially exposed to sulfuric acid aerosol and ozone. Thirty healthy subjects and 30 allergic asthmatic subjects underwent 3-hr exposures in an environmental chamber to 100 micrograms/m3 sulfuric acid and sodium chloride (control) aerosols (...
journal_title:Environmental research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1006/enrs.1995.1020
更新日期:1995-04-01 00:00:00
abstract::The air pollution disasters in London in 1952, the Meuse valley in 1930, and in Donoroa, Pennsylvania, in 1948 made it clear that extremely high levels of particulate-based smog could produce large increases in the daily mortality rate. Recent studies of fluctuations in daily air pollution and daily mortality have rep...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1006/enrs.1994.1004
更新日期:1994-01-01 00:00:00
abstract::The role of humic acids in the transport of trace elements in the Sava river biocycle (near Zagreb, Yugloslavia) has been investigated by means of neutron activation analysis. Humic acids can accumulate certain trace elements, but little is known about their selectivity under certain physicochemical conditions. Humic ...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/s0013-9351(86)80052-4
更新日期:1986-04-01 00:00:00
abstract::Minamata disease is methyl mercury intoxication from fish contaminated by a chemical factory in Minamata city. Based on the results of our regional survey, cardinal clinical features of the disease were clarified by a multivariant analysis of all symptoms in inhabitants in the polluted area. The clinical features were...
journal_title:Environmental research
pub_type: 杂志文章,评审
doi:10.1006/enrs.1993.1137
更新日期:1993-10-01 00:00:00
abstract:BACKGROUND:There is mixed evidence implicating prenatal exposure to particulate matter <2.5 μm in aerodynamic diameter (PM2.5) in the risk of gestational diabetes mellitus (GDM) and only one study has examined exposure to PM2.5 constituents, which vary with location because of different emission sources. METHODS:We co...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2020.109988
更新日期:2020-11-01 00:00:00
abstract::In May 2000, the Agency for Toxic Substances and Disease Registry of the US government conducted a health investigation in response to community concerns regarding ambient and indoor hydrogen sulfide (H(2)S), odor, and health symptoms in Dakota City, Nebraska. The objective was to determine whether adult residents in ...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2003.08.005
更新日期:2004-05-01 00:00:00
abstract::The ability of a methylene chloride extract of diesel exhaust particle (EDEP) to activate the aryl hydrocarbon receptor (AhR), bind to and activate the estrogen receptor (ER), and induce gene expression mediated via these nuclear receptors was examined in Hepa1c1c7 mouse hepatoma and MCF-7 human breast cancer cells. E...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1006/enrs.1998.3870
更新日期:1998-11-01 00:00:00