Effects of paraquat on plasma glucose, cortisol, catecholamines, and insulin in the beagle.

Abstract:

:Paraquat is known to produce hyperglycemia in rodents, although the mechanisms responsible for the hyperglycemic effect of paraquat are not clearly understood. In this study we report the effects of paraquat (25 mg/kg iv) on plasma glucose, cortisol, catecholamines, and insulin in dogs. Paraquat caused a significant increase in plasma glucose level at all times of measurement except at 0.5 hr following paraquat administration. The cortisol levels after paraquat treatment were increased to 133, 305, 279, 418, 517, 672, and 567% above zero time control at 0.5, 1.5, 3, 6, 12, and 24 hr, and at death time respectively. The catecholamines at these times were increased to 42, 17, 72, 118, 138, 226, and 435% above the control. In contrast to cortisol and catecholamines, the plasma insulin levels after paraquat treatment were significantly decreased at 3, 6, 12, and 24 hr. These hormonal observations can explain, at least in part, the observed hyperglycemia, since all promote hyperglycemic states. For example, cortisol is gluconeogenic, catecholamines are glycogenolytic, and lower insulin levels result in depressed peripheral glucose utilization.

journal_name

Environ Res

journal_title

Environmental research

authors

Giri SN,Curry DL,Stabenfeldt G,Spangler WL,Chandler DB,Schiedt MJ

doi

10.1016/0013-9351(83)90169-x

subject

Has Abstract

pub_date

1983-02-01 00:00:00

pages

80-8

issue

1

eissn

0013-9351

issn

1096-0953

pii

0013-9351(83)90169-X

journal_volume

30

pub_type

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