Spermatogenic capacity in fertile men with elevated exposure to polychlorinated biphenyls.

Abstract:

BACKGROUND:Endocrine disrupting industrial chemicals, such as polychlorinated biphenyls (PCBs), are suspected to adversely affect male reproductive functions. OBJECTIVES:The Faroe Islands community exhibits an unusually wide range of exposures to dietary contaminants, and in this setting we examined the possible association between PCB exposure and semen quality and reproductive hormones in fertile Faroese men. METHODS:Participants in this cross-sectional study include 266 proven fertile men residing in the Faroe Islands. PCB levels and hormone profiles were measured in serum samples taken at the clinical examination that included semen quality parameters. RESULTS:A significant positive association was seen between serum-PCB and the testosterone/estradiol ratio (p=0.04). In the unadjusted analyses, elevated PCB exposure was associated with increased serum concentrations of SHBG (p=0.01) and FSH (p=0.05). We found no association between the serum PCB concentration and the semen quality variables. CONCLUSION:In this population of highly exposed fertile men, the current serum-PCB concentration was associated with higher androgen/estrogen ratio. Further studies are needed to establish the findings and further document PCB-associated hormonal effects, any time windows of increased susceptibility, and the role of PCB in sub-fecundity.

journal_name

Environ Res

journal_title

Environmental research

authors

Petersen MS,Halling J,Weihe P,Jensen TK,Grandjean P,Nielsen F,Jørgensen N

doi

10.1016/j.envres.2015.02.030

subject

Has Abstract

pub_date

2015-04-01 00:00:00

pages

345-51

eissn

0013-9351

issn

1096-0953

pii

S0013-9351(15)00065-1

journal_volume

138

pub_type

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