Abstract:
:Pleural calcifications are described in 122 of 268 (45.5%) inhabitants of four villages (Metsovo, Anilio, Milea, and Votonosi) in a small area of northwestern Greece (total population about 5000). All affected individuals are of one ethnic group, Vlachi. Calcifications were not noted in any of the 103 persons in the control group made up of 73 non-Vlachi inhabitants from the same and neighboring villages and 30 Vlachi from distant villages. The calcifications were seen in both sexes, equally, and their frequently increased with age, from 28.6% between 30 and 39 years to 81.0% in individuals over 70 years of age. When plaque development was extensive, a small restrictive pulmonary function defect was noted. Because of its prevalence in the Metsovo area we call this clinical pattern Metsovo lung. The identification of tremolite, related amphibole fibers, and traces of chrysotile fiber in settled dusts and soil specimens and of identical fibers in tissue specimens obtained at lung biopsy from 8 people with plaques supports the hypothesis that abestiform minerals are the agents responsible for these disease processes. Further, reports of the occurrence of mesothelioma and benign pleural effusions in inhabitants in the Metsovo area, along with the striking similarities to disease patterns observed in the Karain area of Turkey, add further weight to the hypothesis that mineral fiber(s) in the environment of the four villages are agent(s) in the etiology of Metsovo lung.
journal_name
Environ Resjournal_title
Environmental researchauthors
Constantopoulos SH,Goudevenos JA,Saratzis N,Langer AM,Selikoff IJ,Moutsopoulos HMdoi
10.1016/0013-9351(85)90096-9subject
Has Abstractpub_date
1985-12-01 00:00:00pages
319-31issue
2eissn
0013-9351issn
1096-0953pii
0013-9351(85)90096-9journal_volume
38pub_type
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