Abstract:
:The effect of exposure to lead on the longitudinal development of the femur and of its cartilage growth plate was studied in rats. A group of forty-five 50-day-old female Wistar rats was divided into a control group of 20 rats and an experimental group of 25 rats fed a diet supplemented with 17 mg of lead acetate per kilogram of feed for 50 days. On Day 50 all rats were killed and their right femurs were dissected. The femurs were cleaned of soft tissue and femoral lengths were measured with a Vernier caliper and thickness of growth cartilage (GPC-Th micron) by histomorphometry. Final body weights were significantly (P < 0.05) lower in the control group than in the rats given the lead-supplemented diet. Femur length did not differ between groups. Histomorphometry of the femur showed that the thickness of growth cartilage was higher (P < 0.05) in the control group. These findings suggested lead-induced inhibition of growth plate development. The growth plate may be one of the key target tissues accounting for the adverse effects of chronic lead exposure on skeletal development.
journal_name
Environ Resjournal_title
Environmental researchauthors
González-Riola J,Hernández ER,Escribano A,Revilla M,Ca-Seco,Villa LF,Rico Hdoi
10.1006/enrs.1997.3760subject
Has Abstractpub_date
1997-01-01 00:00:00pages
91-3issue
1eissn
0013-9351issn
1096-0953pii
S0013935197937609journal_volume
74pub_type
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