Depression of alveolar macrophage hydrogen peroxide and superoxide anion release by mineral dusts: correlation with antimony, lead, and arsenic contents.

Abstract:

:Activated rabbit alveolar macrophages were incubated with airborne dusts from four West German sites (1 to 200 micrograms/10(6) cells) and waste incinerator fly ash fractions (50 to 500 micrograms/10(6) cells). Quartz dust DQ 12 (5 to 200 micrograms/10(6) cells) and Fe2O3 (0.05 to 50 micrograms/10(6) cells) were used as control dusts. The zymosan-stimulated hydrogen peroxide and superoxide anion release of the macrophages were not affected significantly by Fe2O3. All other investigated dusts decreased the two cell functions which were correlated negatively with surfaces, particle numbers, and antimony, lead, and arsenic contents of the dusts. The influence of heavy metal antagonisms and dust surfaces on dust toxicity against alveolar macrophages is discussed.

journal_name

Environ Res

journal_title

Environmental research

authors

Gulyas H,Labedzka M,Gercken G

doi

10.1016/s0013-9351(05)80091-x

subject

Has Abstract

pub_date

1990-04-01 00:00:00

pages

218-29

issue

2

eissn

0013-9351

issn

1096-0953

pii

S0013-9351(05)80091-X

journal_volume

51

pub_type

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