当前位置： SCI文献检索 > ENVIRONMENTAL RESEARCH期刊下所有文献 > Pesticide exposure and end-stage renal disease risk among wives of pesticide applicators in the Agricultural Health Study.

Pesticide exposure and end-stage renal disease risk among wives of pesticide applicators in the Agricultural Health Study.

Abstract：

BACKGROUND:Pesticide exposure has been found to cause renal damage and dysfunction in experimental studies, but epidemiological research on the renal effects of chronic low-level pesticide exposure is limited. We investigated the relationships between end-stage renal disease (ESRD) among wives of licensed pesticide applicators (N=31,142) in the Agricultural Health Study (AHS) and (1) personal pesticide use, (2) exposure to the husband's pesticide use, and (3) other pesticide-associated farming and household activities. METHODS:AHS participants reported pesticide exposure via self-administered questionnaires at enrollment (1993-1997). ESRD cases were identified via linkage to the United States Renal Data System. Associations between ESRD and pesticide exposures were estimated with Cox proportional hazard regression models controlling for age at enrollment. Models of associations with farming and household factors were additionally adjusted for personal use of pesticides. RESULTS:We identified 98 ESRD cases diagnosed between enrollment and 31 December 2011. Although women who ever applied pesticides (56% of cohort) were less likely than those who did not apply to develop ESRD (Hazard Ratio (HR): 0.42; 95% CI: 0.28, 0.64), among women who did apply pesticides, the rate of ESRD was significantly elevated among those who reported the highest (vs. lowest) cumulative general pesticide use (HR: 4.22; 95% CI: 1.26, 14.20). Among wives who never applied pesticides, ESRD was associated with husbands' ever use of paraquat (HR=1.99; 95% CI: 1.14, 3.47) and butylate (HR=1.71; 95% CI: 1.00, 2.95), with a positive exposure-response pattern for husband's cumulative use of these pesticides. CONCLUSIONS:ESRD may be associated with direct and/or indirect exposure to pesticides among farm women. Future studies should evaluate indirect exposure risk among other rural populations.

journal_name

Environ Res

journal_title

Environmental research

authors

Lebov JF,Engel LS,Richardson D,Hogan SL,Sandler DP,Hoppin JA

doi

10.1016/j.envres.2015.10.002

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

198-210

issue

Pt A

eissn

0013-9351

issn

1096-0953

pii

S0013-9351(15)30100-6

journal_volume

143

pub_type

杂志文章

在线工具

Pesticide exposure and end-stage renal disease risk among wives of pesticide applicators in the Agricultural Health Study.