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Prenatal exposure to organophosphorus pesticides and childhood neurodevelopmental phenotypes.

Abstract：

:Prenatal exposure to organophosphorus pesticides (OPs) has been associated with different neurodevelopmental outcomes across different cohorts. A phenotypic approach may address some of these differences by incorporating information across scales and accounting for the complex correlational structure of neurodevelopmental outcomes. Additionally, Bayesian hierarchical modeling can account for confounding by collinear co-exposures. We use this framework to examine associations between prenatal exposure to OPs and behavior, executive functioning, and IQ assessed at age 6-9 years in a cohort of 404 mother/infant pairs recruited during pregnancy. We derived phenotypes of neurodevelopment with a factor analysis, and estimated associations between OP metabolites and these phenotypes in Bayesian hierarchical models for exposure mixtures. We report seven factors: 1) Impulsivity and Externalizing, 2) Executive Functioning, 3) Internalizing, 4) Perceptual Reasoning, 5) Adaptability, 6) Processing Speed, and 7) Verbal Intelligence. These, along with the Working Memory Index, were standardized and scaled so that positive values reflected positive attributes and negative values represented adverse outcomes. Standardized dimethylphosphate metabolites were negatively associated with Internalizing factor scores (β^ - 0.13, 95% CI - 0.26, 0.00) but positively associated with Executive Functioning factor scores (β^ 0.18, 95% CI 0.04, 0.31). Standardized diethylphosphate metabolites were negatively associated with the Working Memory Index (β^ - 0.17, 95% CI - 0.33, - 0.03). Associations with factor scores were generally stronger and more precise than associations with individual instrument-specific items. Factor analysis of outcomes may provide some advantages in etiological studies of childhood neurodevelopment by incorporating information across scales to reduce dimensionality and improve precision.

journal_name

Environ Res

journal_title

Environmental research

authors

Furlong MA,Herring A,Buckley JP,Goldman BD,Daniels JL,Engel LS,Wolff MS,Chen J,Wetmur J,Barr DB,Engel SM

doi

10.1016/j.envres.2017.07.023

subject

Has Abstract

pub_date

2017-10-01 00:00:00

pages

737-747

eissn

0013-9351

issn

1096-0953

pii

S0013-9351(17)30104-4

journal_volume

158

pub_type

杂志文章

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Prenatal exposure to organophosphorus pesticides and childhood neurodevelopmental phenotypes.