Abstract：
:N-Methyl-N-nitrosourea (MNU) and methyl methanesulfonate (MMS) were found to rapidly methylate glutathione (GSH) in vitro yielding S-methyl glutathione, as verified and quantitated by high-performance liquid chromatography and thin-layer chromatography. Formation of S-methylcysteine in the acid-hydrolyzate of the methylated GSH further confirmed the formation of S-methyl glutathione. Other naturally occurring thiol compounds such as cysteine and homocysteine were also methylated by MNU. The observed pH dependency of GSH methylation by MNU suggests that the sulfide anion form of the thiol may represent the favored methyl acceptor. The high reactivity of GSH toward MNU and MMS may be of biological significance in that it could compete with macromolecular cellular components as a target for alkylation.
journal_name
Environ Resjournal_title
Environmental researchauthors
Trézl L,Park KS,Kim S,Paik WKdoi
10.1016/s0013-9351(87)80042-7subject
Has Abstractpub_date
1987-08-01 00:00:00pages
417-26issue
2eissn
0013-9351issn
1096-0953pii
S0013-9351(87)80042-7journal_volume
43pub_type
杂志文章abstract：:Concentrated human milk (HM-concentrate) can be obtained from the simple and inexpensive method of donated breast milk direct lyophilization. A previous study reported that HM-concentrate contains the adequate amount of main macro- and micronutrients for use as a nutritional resource for preterm infants with very low ...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2020.109733
更新日期：2020-09-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2017.09.006
更新日期：2018-01-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章,评审
doi：10.1006/enrs.2000.4110
更新日期：2001-02-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1006/enrs.1997.3812
更新日期：1998-08-01 00:00:00
abstract：:Epidemiologic studies have suggested that exposure to solvent-based materials in the painting trades is associated with an increased cancer risk. In order to determine if the solvent exposures of current union members of the International Brotherhood of Painters and Allied Tradesman (IBPAT) are associated with a genot...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/s0013-9351(89)80005-2
更新日期：1989-12-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/s0013-9351(86)80081-0
更新日期：1986-06-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
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更新日期：2020-07-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2016.03.025
更新日期：2016-07-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/s0013-9351(89)80050-7
更新日期：1989-10-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
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更新日期：2020-06-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2019.02.015
更新日期：2019-05-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2006.06.012
更新日期：2007-03-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1006/enrs.1997.3718
更新日期：1997-01-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章,评审
doi：10.1016/j.envres.2020.109868
更新日期：2020-09-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/s0013-9351(87)80053-1
更新日期：1987-06-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2019.01.030
更新日期：2019-04-01 00:00:00
abstract：:Human exposure to poly- and perfluoroalkyl substances (PFASs) is widespread and has received considerable attention in recent years due to their link with adverse health outcomes, including bone health. Nevertheless, no earlier studies have reported serum PFAS concentrations, and their association with incident osteop...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2020.109676
更新日期：2020-08-01 00:00:00
abstract：:The toxicity of isopropyl alcohol (IPA) on the nasal mucosa in the guinea pig was experimentally studied, with special reference to the recovery process of the organ. The results showed that 400 ppm of IPA has an acute effect on the nasal mucosa and the recovery from such degeneration can occur in 2 weeks. When functi...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/s0013-9351(88)80056-2
更新日期：1988-06-01 00:00:00
abstract：:At the end of December 2019, the rapid spread of the COVID-19 (SARS-CoV-2) disease and, subsequently, deaths around the world, lead to the declaration of the pandemic situation in the world. At the beginning of the epidemic, much attention is paid to person-to-person transmission, disinfection of virus-contaminated su...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2020.110612
更新日期：2021-02-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2020.110565
更新日期：2021-02-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1006/enrs.1993.1029
更新日期：1993-02-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2017.11.046
更新日期：2018-02-01 00:00:00
abstract：:Copyright ...
journal_title：Environmental research
pub_type： 杂志文章
doi：
更新日期：1998-04-01 00:00:00
abstract：:The Brazilian coast of the Rio de Janeiro State has bays of great economic, ecological and social importance. However, these ecosystems have been suffering intense anthropogenic influence, mainly due to the contamination by polycyclic aromatic hydrocarbons (PAHs) from urban-industrial activities. Moreover, PAHs are or...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2019.108959
更新日期：2020-02-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/s0013-9351(05)80234-8
更新日期：1992-10-01 00:00:00
abstract：:The relationship between external exposure and internal doses of polycyclic aromatic hydrocarbons (PAHs) has not been established for people living in industrial areas. This study was carried out to estimate the relationship between particle-phase PAH exposure and urinary 1-hydroxypyrene (1-OHP) levels among the adult...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2014.10.007
更新日期：2015-01-01 00:00:00
abstract：:The production of thiobarbituric acid-reactive substances (TBA-RS) and ethane, two markers of the lipid peroxidation process, was evaluated in rat lung and liver microsomal membranes incubated in the presence of either ferrous ions or a mixture of ferric ions and ascorbate. Microsomal fractions isolated from lung tiss...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1006/enrs.1995.1047
更新日期：1995-07-01 00:00:00
abstract：BACKGROUND:Tobacco smoke exposure increases the risk of cancer in the liver, but little is known about the possible risk associated with exposure to ambient air pollution. OBJECTIVES:We evaluated the association between residential exposure to air pollution and primary liver cancer incidence. METHODS:We obtained data...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2017.01.006
更新日期：2017-04-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2017.08.020
更新日期：2017-11-01 00:00:00
abstract：:The effect of acute exposure to nitrogen dioxide (NO2) on anti-SRBC antibody response in two lines of Japanese quails, high and low responder, was investigated. Mean survival time of 11- to 13-week-old quails after exposure to 20 ppm NO2 was 12.0 hr. The high responder line lived longer than the low responder line. Ch...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/0013-9351(84)90146-4
更新日期：1984-12-01 00:00:00
