当前位置： SCI文献检索 > ENVIRONMENTAL RESEARCH期刊下所有文献 > Sulfuric acid aerosol followed by ozone exposure in healthy and asthmatic subjects.

Sulfuric acid aerosol followed by ozone exposure in healthy and asthmatic subjects.

Abstract：

:These studies evaluated symptom and pulmonary function responses of humans sequentially exposed to sulfuric acid aerosol and ozone. Thirty healthy subjects and 30 allergic asthmatic subjects underwent 3-hr exposures in an environmental chamber to 100 micrograms/m3 sulfuric acid and sodium chloride (control) aerosols (in random order), followed 24 hr later by 3-hr exposures to ozone (0.08, 0.12, or 0.18 ppm). Each subject was studied four times, receiving each aerosol preexposure followed by two of the three ozone concentrations. For the healthy group, no convincing symptomatic or physiologic effects of exposure to either the aerosol or ozone on lung function were found. For the asthmatic group, preexposure to sulfuric acid altered the pattern of response to ozone in comparison with sodium chloride preexposure and appeared to enhance the small mean decrements in FVC that occurred in response to 0.18 ppm ozone (means +/- SE: -3.6 +/- 1.5% with sodium chloride preexposure, -6.8 +/- 1.7% with sulfuric acid preexposure). Individual responses among asthmatic subjects were quite variable, some demonstrating reductions in FEV1 of more than 35% following ozone exposure. Analysis of variance of changes in FVC revealed evidence for interactions between aerosol and ozone exposure both immediately after (P = 0.005) and 4 hr after (P = 0.030) exposure. Similar effects were seen for FEV1. When normal and asthmatic subjects were combined, four-way analysis of variance revealed an interaction between ozone and aerosol for the entire group (P = 0.0022) and a difference between normal and asthmatic subjects (P = 0.0048). There was no significant effect of exposures on symptoms for either normal or asthmatic subjects. Asthmatic subjects differ from healthy volunteers in their functional responses following sequential exposures to aerosols and ozone and appear to represent a susceptible population.

journal_name

Environ Res

journal_title

Environmental research

authors

Frampton MW,Morrow PE,Cox C,Levy PC,Condemi JJ,Speers D,Gibb FR,Utell MJ

doi

10.1006/enrs.1995.1020

subject

Has Abstract

pub_date

1995-04-01 00:00:00

pages

1-14

issue

eissn

0013-9351

issn

1096-0953

pii

S0013-9351(85)71020-1

journal_volume

pub_type

临床试验,杂志文章,随机对照试验

在线工具

Sulfuric acid aerosol followed by ozone exposure in healthy and asthmatic subjects.