Abstract：
:n-Hexane is used in industry as a solvent for adhesive, dry cleaning, and vegetable oil extraction. In 1963, the first case of severe polyneuropathy suspected to be caused by n-hexane was referred to us. Case studies, animal experiments, and field surveys on n-hexane poisoning were conducted, and preventive measures like threshold limit value revision and biological monitoring were also studied. I review a brief history of our investigations on n-hexane poisoning and its preventive measures in Japan. n-Hexane could cause overt polyneuropathy in workers exposed to more than 100 ppm time-weighted average concentrations [TWA]. The present threshold limit value of 40 ppm in Japan is considered low enough to prevent subclinical impairment of peripheral nerve caused by n-hexane. Urinary 2,5-hexanedione could be a good indicator for biological monitoring of n-hexane exposure. About 2.2 mg/liter of 2,5-hexanedione measured by our improved method corresponds to exposure of 40 ppm (TWA) of n-hexane.
journal_name
Environ Resjournal_title
Environmental researchauthors
Takeuchi Ydoi
10.1006/enrs.1993.1091subject
Has Abstractpub_date
1993-07-01 00:00:00pages
76-80issue
1eissn
0013-9351issn
1096-0953pii
S0013-9351(83)71091-1journal_volume
62pub_type
杂志文章,评审abstract：:Dust wipe samples collected in the field were tested by nondestructive X-ray fluorescence (XRF) followed by laboratory analysis with flame atomic absorption spectrophotometry (FAAS). Data were analyzed for precision and accuracy of measurement. Replicate samples with the XRF show high precision with an intraclass corr...
journal_title：Environmental research
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更新日期：2000-06-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
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journal_title：Environmental research
pub_type： 杂志文章
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更新日期：2011-02-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2020-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.envres.2013.12.004
更新日期：2014-02-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
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更新日期：2019-10-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/s0013-9351(87)80035-x
更新日期：1987-08-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
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更新日期：2020-03-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2008.02.009
更新日期：2008-07-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.envres.2014.10.011
更新日期：2015-01-01 00:00:00
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更新日期：2017-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：1988-02-01 00:00:00
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更新日期：2020-08-01 00:00:00
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更新日期：1992-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：2007-03-01 00:00:00
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更新日期：2003-11-01 00:00:00
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pub_type： 杂志文章
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更新日期：2018-10-01 00:00:00
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更新日期：2019-02-01 00:00:00
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journal_title：Environmental research
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更新日期：2005-11-01 00:00:00
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更新日期：2021-01-25 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2018.10.014
更新日期：2019-02-01 00:00:00
