Abstract：
:The in vitro genotoxic and the soft-agar anchorage independent cell transformation ability of titanium dioxide nanoparticles (nano-TiO2) and its microparticulated form has been evaluated in human embryonic kidney (HEK293) and in mouse embryonic fibroblast (NIH/3T3) cells. Nano-TiO2 of two different sizes (21 and 50 nm) were used in this study. The comet assay, with and without the use of FPG enzyme, the micronucleus assay and the soft-agar colony assay were used. For both the comet assay and the frequency of micronuclei a statistically significant induction of DNA damage, was observed at the highest dose tested (1000 µg/mL). No oxidative DNA damage induction was observed when the comet assay was complemented with the use of FPG enzyme. Furthermore, long-term exposure to nano-TiO2 has also proved to induce cell-transformation promoting cell-anchorage independent growth in soft-agar. Results were similar for the two nano-TiO2 sizes. Negative results were obtained when the microparticulated form of TiO2 was tested, indicating the existence of important differences between the microparticulated and nanoparticulated forms. As a conclusion it should be indicated that the observed genotoxic/tranforming effects were only detected at the higher dose tested (1000 µg/mL) what play down the real risk of environmental exposures to this nanomaterial.
journal_name
Environ Resjournal_title
Environmental researchauthors
Demir E,Akça H,Turna F,Aksakal S,Burgucu D,Kaya B,Tokgün O,Vales G,Creus A,Marcos Rdoi
10.1016/j.envres.2014.10.032subject
Has Abstractpub_date
2015-01-01 00:00:00pages
300-8eissn
0013-9351issn
1096-0953pii
S0013-9351(14)00396-Xjournal_volume
136pub_type
杂志文章abstract：:Short-term exposure to ambient air pollution is associated with increased cardiovascular mortality and morbidity. This adverse health effect is suggested to be mediated by inflammatory processes. The purpose of this study was to determine if low levels of particulate matter, typical for smaller cities, are associated ...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2012.04.004
更新日期：2012-07-01 00:00:00
abstract：:The aim of this study was to assess the odor immission derived from full-scale composting of different abundant and highly pollutant organic waste: sewage sludge with bulking agent (SL), sewage sludge pretreated through anaerobic digestion and supplemented with bulking agent (SL-AD), and market waste with olive leaves...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2018.09.001
更新日期：2018-11-01 00:00:00
abstract：:Seawater pollution problems are gaining interest worldwide because of their public health impact and other issues. Levels of pollutants at Gaza Beach determined the only recreational area for the inhabitants of Gaza were recently determined and shown to be high. Five bathing sites in the Middle Camps area along the Ga...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2005.07.005
更新日期：2006-05-01 00:00:00
abstract：:The production of thiobarbituric acid-reactive substances (TBA-RS) and ethane, two markers of the lipid peroxidation process, was evaluated in rat lung and liver microsomal membranes incubated in the presence of either ferrous ions or a mixture of ferric ions and ascorbate. Microsomal fractions isolated from lung tiss...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1006/enrs.1995.1047
更新日期：1995-07-01 00:00:00
abstract：:Ambient air pollution is the leading environmental risk factor for disease globally. Air pollutants can increase the risk of some respiratory infections, but their effects on tuberculosis (TB) are unclear. In this systematic literature review, we aimed to assess epidemiological studies on the association between outdo...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2018.12.011
更新日期：2019-03-01 00:00:00
abstract：BACKGROUND:Drinking water (DW) is an important dietary source of magnesium. Recently, Israel has increased its use of desalinated seawater (DSW) as DW country-wide. Its negligible magnesium content, however, raises concern that consumption of DSW may be associated with hypomagnesemia and increase the risk of ischemic h...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2018.06.053
更新日期：2018-10-01 00:00:00
abstract：BACKGROUND:Bisphenols F (BPF) and S (BPS) are bisphenol A (BPA) analogs used as substitutes in consumer products. Despite previous reports of BPA's association with asthma, no studies have examined its structural analogs in relation to asthma and allergy outcomes. OBJECTIVE:To examine the association of urinary BPF, B...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2019.108944
更新日期：2020-04-01 00:00:00
abstract：:Phthalates are synthetic contaminants released into the environment notably by plastic waste. Semi-volatile, they adsorb to atmospheric particles and get distributed in all ecosystems. Effects of this major anthropogenic pollution in economical species in aquatic habitats have attracted large interest. On the contrary...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2014.03.016
更新日期：2014-05-01 00:00:00
abstract：:Hamsters were exposed to an intratracheal instillation of 0.5 ml of 0.08 N nitric, hydrochloric, or sulfuric acid to determine their airway epithelial response. Three weeks after exposure, the left intrapulmonary bronchi in Alcian blue/PAS-stained paraffin sections were evaluated for the amount of secretory product in...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/s0013-9351(88)80010-0
更新日期：1988-02-01 00:00:00
abstract：:In this research, the concentrations of six heavy metals (Zn, Pb, Ni, Fe, Cd, and Cr) in electronic cigarette (EC) solutions were determined to assess their association with EC use patterns. To this end, their contents were analyzed under three conditions: (1) ECL I: EC liquid was directly taken from EC liquid bottles...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2019.04.025
更新日期：2019-07-01 00:00:00
abstract：:Compliance with 24-h urine samples can be low in population-based studies and first morning void urine samples are often collected for convenience. Interpretation of arsenic concentrations in urine is influenced by a range of factors unrelated to exposure. To reduce the influence of such factors, creatinine adjustment...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1006/enrs.2002.4339
更新日期：2002-03-01 00:00:00
abstract：:The California Power Line Study is a case-control study investigating the relation between residences near transmission lines and risk of childhood leukemia. It includes 5788 childhood leukemia cases and 5788 matched primary controls born between 1986 and 2007. We describe the methodology for estimating magnetic field...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2015.04.020
更新日期：2015-07-01 00:00:00
abstract：BACKGROUND:Although air pollution and social stress may independently increase childhood asthma, little is known on their synergistic effect on asthma, particularly in China with high levels of stress and air pollution. OBJECTIVES:To examine associations between exposure to a combination of parental stress and air pol...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2018.04.003
更新日期：2018-08-01 00:00:00
abstract：OBJECTIVE:Phthalates are non-persistent pollutants related to impaired metabolism and high cardiovascular risk. Their toxic metabolites are eliminated through urine and feces. Prevention policies are considered by the governments, although no therapeutic strategy to facilitate their elimination from the human body has ...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2020.110316
更新日期：2021-01-01 00:00:00
abstract：:Long-Evans rats, 4-6 weeks of age, were given access to 0, 1, 10, or 100 ppm sodium chlorite in deionized water ad libitum as drinking water. Males were exposed 56 days, and females for 14 days prior to breeding and throughout the 10-day breeding period. Males were evaluated for sperm parameters and reproductive tract...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/s0013-9351(87)80025-7
更新日期：1987-02-01 00:00:00
abstract：:To determine pulmonary deposition and clearance of inhaled volcanic ash, rats received a single 60-min, nose-only exposure to neutron-activated ash. Over a period of 128 days after exposure, the rats were sacrificed in groups of five animals. Lungs were analyzed for the radionuclide tracers 46Sc, 59Fe, and 60Co by gam...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/0013-9351(84)90129-4
更新日期：1984-10-01 00:00:00
abstract：INTRODUCTION:Accumulating evidence indicates that arsenic (As), a potent environmental toxicant, may increase cardiovascular disease risk and adversely affect endothelial function at high levels of exposure. Pregnancy is a vulnerable time for both mother and child; however, studies examining the association between pre...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2017.03.056
更新日期：2017-07-01 00:00:00
abstract：:Concentrated human milk (HM-concentrate) can be obtained from the simple and inexpensive method of donated breast milk direct lyophilization. A previous study reported that HM-concentrate contains the adequate amount of main macro- and micronutrients for use as a nutritional resource for preterm infants with very low ...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2020.109733
更新日期：2020-09-01 00:00:00
abstract：:A few epidemiologic studies suggest that exposure to bisphenol A (BPA) is associated with type 2 diabetes mellitus (T2DM). However, little is known about association between other phenolic endocrine disrupting chemicals (EDCs) and T2DM. In this case-control study, we measured urinary concentrations of 23 phenolic EDCs...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2018.06.040
更新日期：2018-10-01 00:00:00
abstract：:Previous estimates of childhood lead poisoning prevention benefits have quantified the present value of some health benefits, but not the costs of lead paint hazard control or the benefits associated with housing and energy markets. Because older housing with lead paint constitutes the main exposure source today in th...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2007.09.003
更新日期：2008-03-01 00:00:00
abstract：:The median nerve somatosensory evoked potentials (SEP), pattern reversal visual evoked potentials (VEP), and brain stem auditory evoked potentials (BAEP) were studied in 109 healthy adults and in 88 patients with acute carbon monoxide (CO) poisoning. The upper limits for normal values of peak and interpeak latencies o...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1006/enrs.1993.1029
更新日期：1993-02-01 00:00:00
abstract：:The importance of secondary raw materials for phosphorus (P) fertilizer production is expected to increase in the future due to resource depletion, supply risks, and heavy metal contamination of fossil phosphate resources. Municipal wastewater is a promising source for P recovery. In Germany for instance, it contains ...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2017.02.034
更新日期：2017-05-01 00:00:00
abstract：:Bioelectrochemical systems (BESs) exhibit great potential for simultaneous wastewater treatment and energy recovery. However, the efficiency of microbial electrocatalysis is fundamentally limited by the high resistance and poor biocompatibility of electrode materials. Herein, we construct a novel "binder-free" 3D bioc...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2020.110212
更新日期：2020-12-01 00:00:00
abstract：:Introduction There is evidence of improvement on mental health and well-being due to contact with green spaces, through various mechanisms and with potentially differential impacts in different populations. Many of these studies have been conducted among adults, while children have not been sufficiently investigated. ...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2020.110358
更新日期：2020-10-24 00:00:00
abstract：:Cadmium (Cd) was determined in kidney cortex and liver of 173 autopsied Japanese. Subjects consisted of 51 persons from Cd-polluted areas ages between 61-94 years and 122 controls ages between 3-90 years. The mean Cd concentrations for the Cd-polluted group were 35.2 micrograms/g wet wt for kidney cortex and 66.7 micr...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/s0013-9351(86)80101-3
更新日期：1986-08-01 00:00:00
abstract：:One etiologic model for narcolepsy suggests that some environmental toxin selectively and irreversibly destroys hypocretin-producing cells in individuals with human leukocyte antigen (HLA) DQB1(*)0602. Between 2001 and 2005, the authors conducted a population-based case-control study in King County, Washington to exam...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2010.05.002
更新日期：2010-08-01 00:00:00
abstract：OBJECTIVE:To assess the relationship between in utero and concurrent child urinary exposures to bisphenol A (BPA) and phthalates with BMI z-score, waist circumference, and sum of triceps and subscapular skinfold thickness in Mexican children. METHODS:Among participants (N=249) from the Early Life Exposure in Mexico to...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2017.03.038
更新日期：2017-07-01 00:00:00
abstract：:In the current context of climate change, heat waves have become a significant problem for human health. This study assesses the effects of heat wave intensity on mortality (natural, respiratory and cardiovascular causes) in four of the largest cities of Spain (Barcelona, Bilbao, Madrid and Seville) during the period ...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2019.109027
更新日期：2020-03-01 00:00:00
abstract：BACKGROUND:Human biomonitoring studies have demonstrated decreasing concentrations of many persistent organic pollutants (POPs) in years after emission peaks. OBJECTIVES:To describe time trends of POPs in blood using four cross-sectional samples of 30 year olds from Tromsø, Norway across 1986-2007, and to compare the ...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2019.02.047
更新日期：2019-05-01 00:00:00
abstract：BACKGROUND:Micronuclei (MNs) are extranuclear DNA-containing bodies and determining MN frequencies is a measure of genomic instability. An age-related increase in MN frequencies in lymphocytes has been quantified, but this effect has not yet been measured in nasal and buccal cells. METHODS:We determined the effect of ...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2019.108824
更新日期：2020-01-01 00:00:00
