Abstract:
BACKGROUND:Micronuclei (MNs) are extranuclear DNA-containing bodies and determining MN frequencies is a measure of genomic instability. An age-related increase in MN frequencies in lymphocytes has been quantified, but this effect has not yet been measured in nasal and buccal cells. METHODS:We determined the effect of age on the MN frequency distributions in buccal and nasal cells among a sample of a general adult population in Switzerland. To maximize the power to detect an effect of age in our population study, we recruited preferentially younger and older working age adults. We harvested buccal and nasal cells from 32 young (19-36 year) and 33 working age (47-71 years) participants. The collected cells were washed, centrifuged, and stained (Feulgen) before microscopic manual counting in 2000 cells. Based on these results, we developed an age-dependent background MN frequency chart to help interpret an individual's MN frequency score as an early signal for the effect of genotoxic exposure. RESULTS:MN frequencies were respectively 0.53‰ and 0.47‰ for buccal and nasal among the younger and 0.87‰ and 1.03‰ in the older working age group. This corresponded to a multiplicative slope of 14% and 20% per 10 years of age for buccal and nasal cells, respectively. CONCLUSION:Based on our study results, we are able to propose an approach for interpreting an individual's MN screening results.
journal_name
Environ Resjournal_title
Environmental researchauthors
Hopf NB,Danuser B,Bolognesi C,Wild Pdoi
10.1016/j.envres.2019.108824subject
Has Abstractpub_date
2020-01-01 00:00:00pages
108824eissn
0013-9351issn
1096-0953pii
S0013-9351(19)30621-8journal_volume
180pub_type
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