Abstract：
:Hamsters were exposed to an intratracheal instillation of 0.5 ml of 0.08 N nitric, hydrochloric, or sulfuric acid to determine their airway epithelial response. Three weeks after exposure, the left intrapulmonary bronchi in Alcian blue/PAS-stained paraffin sections were evaluated for the amount of secretory product in the airway epithelium as a measure of secretory cell metaplasia (SCM). Compared to saline-treated control animals, all three acids caused statistically significant SCM. In addition to the bronchial lesion, all three acids caused similar interstitial fibrosis, bronchiolectasis, and bronchiolization of alveoli that varied in individual animals from mild to severe. In a separate experiment to study the persistence of the SCM, hamsters treated with a single instillation of 0.1 N nitric acid showed significant SCM 3, 7, and 17 weeks after exposure. There was a high correlation (r = 0.96) between a subjective assessment of SCM and objective assessment using a digital image-analysis system. We conclude that protons induce SCM independently of the associated anion; the SCM persists at least 17 weeks. Sulfuric acid is an atmospheric pollutant and nitric acid may form locally on the mucosa of lungs exposed to nitrogen dioxide. These acids may contribute to the development or maintenance of the SCM seen in the conducting airways of humans with chronic obstructive pulmonary disease.
journal_name
Environ Resjournal_title
Environmental researchauthors
Christensen TG,Lucey EC,Breuer R,Snider GLdoi
10.1016/s0013-9351(88)80010-0subject
Has Abstractpub_date
1988-02-01 00:00:00pages
78-90issue
1eissn
0013-9351issn
1096-0953pii
S0013-9351(88)80010-0journal_volume
45pub_type
杂志文章abstract：:Simulating allergenic tree pollen is important to protect sensitive population and to support bioaerosols monitoring effort. Using the regional air quality model GEM-MACH, a simulation was conducted adopting two new main hypotheses: 1) the use of vertical correlation concept to force the vertical dispersion (a method ...
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journal_title：Environmental research
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pub_type： 杂志文章
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journal_title：Environmental research
pub_type： 杂志文章
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更新日期：2019-11-01 00:00:00
