The pathogenicity of dust from a fluorite mine.

Abstract:

:The pathogenicity of mixed dust from a fluorite mine was studied by animal experiments and in vitro tests. Animal experiments showed that calcium fluorite can induce only a foreign body reaction in the lungs; the fibrous nodular lesions induced by the fluorite mine dust are due mainly to its silica component. It was demonstrated that either silica or the mixed dust of a fluorite mine can stimulate pulmonary alveolar macrophages (PAMs) to release fibrogenetic factors in vitro, but calcium fluorite cannot. It was also demonstrated that having engulfed calcium fluorite, silica, or fluorite mine mixed dust, PAMs release an elastase-active substance. The authors suggest that the emphysematous lesion seen in autopsy material of pneumoconiosis of fluorite mine workers may be caused by calcium fluorite and silica.

journal_name

Environ Res

journal_title

Environmental research

authors

Xu YH,Zhang SJ,Wu CQ,Zhou J,Chang HF,Yu SQ

doi

10.1016/s0013-9351(87)80035-x

subject

Has Abstract

pub_date

1987-08-01 00:00:00

pages

350-8

issue

2

eissn

0013-9351

issn

1096-0953

pii

S0013-9351(87)80035-X

journal_volume

43

pub_type

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