当前位置： SCI文献检索 > ENVIRONMENTAL RESEARCH期刊下所有文献 > Phthalate exposure during pregnancy and long-term weight gain in women.

Phthalate exposure during pregnancy and long-term weight gain in women.

Abstract：

BACKGROUND:Phthalates are known endocrine disruptors and peroxisome proliferator-activated receptor (PPAR) activators, potentially capable of promoting an obesogenic effect. Pregnant women are especially vulnerable to phthalate exposure due to physiological and metabolic changes during pregnancy, including those related to the metabolism of xenobiotics. Phthalate exposure during pregnancy has been associated with early gestational weight gain, however, its effect on long-term weight gain remains unclear. The aim of the present study was to evaluate the association between phthalate exposure during pregnancy and long-term changes in weight among women. METHODS:Urinary phthalate concentrations, socioeconomic, anthropometry and information on diet and socioeconomic status were collected during pregnancy from 178 women from the Early Life Exposure in Mexico to Environmental Toxicants (ELEMENT) birth cohort. Maternal body weight and diet information was also collected up to 5 times in the first year postpartum and twice during follow-up visits 5.2-10.7 years later. A path analysis was performed to assess associations between urinary phthalate metabolite levels during pregnancy and change in weight (kg) per year after delivery, including age, education, living with/without partner, parity, daily energy intake and breastfeeding duration. RESULTS:The mean age at pregnancy was 27.3 ± 5.9 years and mean body mass index during the first postpartum year was 27.07 ± 4.22 kg/m2. On average, women gained 3.48 kg (0.52 ± 0.84 kg/year). A unit increase in log-transformed mono-3-carboxypropyl phthalate (MCPP) was associated with 0.33 kg (95% CI: 0.09, 0.56) higher weight gain per year, and mono-benzyl phthalate (MBzP) with 0.21 kg (95% CI: -0.38, -0.03) lower weight gain per year. CONCLUSION:Exposure to certain phthalates during pregnancy may be associated with long-term weight change in women. More studies on the effects of phthalate exposure during pregnancy on women's long-term health are required.

journal_name

Environ Res

journal_title

Environmental research

authors

Rodríguez-Carmona Y,Cantoral A,Trejo-Valdivia B,Téllez-Rojo MM,Svensson K,Peterson KE,Meeker JD,Schnaas L,Solano M,Watkins DJ

doi

10.1016/j.envres.2018.10.014

subject

Has Abstract

pub_date

2019-02-01 00:00:00

pages

26-32

eissn

0013-9351

issn

1096-0953

pii

S0013-9351(18)30549-8

journal_volume

169

pub_type

杂志文章

在线工具

Phthalate exposure during pregnancy and long-term weight gain in women.