Abstract:
BACKGROUND:Extracellular vesicles (EVs) represent a plausible molecular mechanism linking particulate matter (PM) inhalation to its systemic effects. Microvesicles (MVs) are released from many cell types in response to various stimuli. Increased body mass index (BMI) could modify the response to PM exposure due to enhanced PM uptake and/or an underlying pro-oxidative state. We investigated the relationship between EV release and PM10/PM2.5 exposure in a cohort of 51 volunteers. Subjects were stratified based on their BMI to evaluate whether overweight BMI is a determinant of hypersusceptibility to PM effects. RESULTS:Exposure to PM10/PM2.5 was assessed with a personal sampler worn for 24hours before plasma collection and confirmed with monitoring station data. Size and cellular origin of plasma EVs were characterized by Nanosight analysis and flow cytometry, respectively. Multivariate regression models were run after log-transformation, stratifying subjects based on BMI (≥ or <25kg/m2). PM exposure resulted in increased release of EVs, with the maximum observed effect for endothelial MVs. For PM10 and PM2.5, the adjusted geometric mean ratio and 95% confidence interval were 3.47 (1.30, 9.27) and 3.14 (1.23, 8.02), respectively. Compared to those in normal subjects, PM-induced EV alterations in overweight subjects were more pronounced, with visibly effect in all MV subtypes, particularly endothelial MVs. CONCLUSIONS:Our findings emphasize the role of EV release after PM exposure and the susceptibility of overweight subjects. Larger studies with accurate exposure assessment and complete EVs characterization/content analysis, could further clarify the molecular mechanism responsible for PM effects and of hypersusceptibility of overweight subjects.
journal_name
Environ Resjournal_title
Environmental researchauthors
Bonzini M,Pergoli L,Cantone L,Hoxha M,Spinazzè A,Del Buono L,Favero C,Carugno M,Angelici L,Broggi L,Cattaneo A,Pesatori AC,Bollati Vdoi
10.1016/j.envres.2017.02.014subject
Has Abstractpub_date
2017-05-01 00:00:00pages
228-234eissn
0013-9351issn
1096-0953pii
S0013-9351(16)31156-2journal_volume
155pub_type
杂志文章abstract:OBJECTIVE:Longitudinal studies on neurobehavioral development in relation to prenatal and postnatal exposure to phthalates in school-age children and adolescents are limited. We investigated the association of prenatal and childhood phthalate exposure with the development of behavioral syndromes in 8-14-year-old childr...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2019.02.029
更新日期:2019-05-01 00:00:00
abstract::As a fast and effective technique, the multiple linear regression (MLR) method has been widely used in modeling and prediction of beach bacteria concentrations. Among previous works on this subject, however, several issues were insufficiently or inconsistently addressed. Those issues include the value and use of inter...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2006.11.006
更新日期:2007-03-01 00:00:00
abstract::The effects of low-level lead exposure on neuropsychological status in the United States (US) general adult population have been reported, and the relationship between neuropsychiatric dysfunction and health risk behaviors including substance use and sexual risk taking is well established. However, the potential influ...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2014.05.037
更新日期:2014-11-01 00:00:00
abstract::The apparent fractional absorption of cadmium (Cd) from sunflower kernels (SFK) was determined in women volunteers by using kernels labeled with a stable isotope of Cd ((113)Cd) by injecting it into the flowering head. Fourteen women who were between the ages of 30 and 70 years, who did not use tobacco products, who w...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1006/enrs.2001.4288
更新日期:2001-10-01 00:00:00
abstract:BACKGROUND:Few studies have examined temperature's effect on adverse birth outcomes and relevant effect modifiers. OBJECTIVES:We investigated associations between heat and adverse birth outcomes and how individual and community characteristics affect these associations for Seoul, Korea, 2004-2012. METHODS:We applied ...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2018.10.032
更新日期:2019-01-01 00:00:00
abstract::The objectives of this study were to examine levels of arsenic, cadmium, lead, mercury and selenium in edible tissue of seven species of marine fish collected from several Aleutian islands (in 2004) to determine: (1) interspecific differences, (2) locational differences (among Aleutian Islands), (3) size-related diffe...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2014.02.016
更新日期:2014-05-01 00:00:00
abstract::Tobacco smoke-related air pollutant levels were studied in ten Finnish restaurants. Markers of tobacco smoke were measured together with other compounds typical of tobacco smoke and indoor air. The measurements were carried out at stationary sampling points in smoking and non-smoking areas of the restaurants in 2005-2...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2008.07.020
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVES:We systematically reviewed the published studies on the relationship between dengue fever and meteorological factors and applied a meta-analysis to explore the effects of ambient temperature and precipitation on dengue fever. METHODS:We completed the literature search by the end of September 1st, 2019 using...
journal_title:Environmental research
pub_type: 杂志文章,meta分析
doi:10.1016/j.envres.2020.110043
更新日期:2020-12-01 00:00:00
abstract::There is interest in determining the relationship between fine particulate matter air pollution and various health outcomes, including birth outcomes such as term low birth weight. Previous studies have come to different conclusions. In this study we consider whether the effect may vary by location and gestational per...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2014.05.034
更新日期:2014-10-01 00:00:00
abstract::Penicillic acid (PA) is a polyketide mycotoxin produced by several species of Aspergillus and Penicillium. This mycotoxin is toxic in experimental animals and has also been reported to be carcinogenic. The cytotoxicity of penicillic acid was studied in rat alveolar macrophages (AM) in vitro. The effects of penicillic ...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/s0013-9351(86)80145-1
更新日期:1986-12-01 00:00:00
abstract:BACKGROUND:Polychlorinated biphenyls (PCBs) were used in electrical equipment and a range of construction materials. Although banned in the United States and most of Europe in the 1970s, they are highly persistent in the environment and bioaccumulate. Whether PCBs are associated with liver cancer risk at general popula...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2020.109690
更新日期:2020-08-01 00:00:00
abstract::Selenium (Se) contamination in surface and ground water in numerous river basins has become a critical problem worldwide in recent years. The exposure to Se, either direct consumption of Se or indirectly may be fatal to the human health because of its toxicity. The review begins with an introduction of Se chemistry, d...
journal_title:Environmental research
pub_type: 杂志文章,评审
doi:10.1016/j.envres.2018.02.037
更新日期:2018-07-01 00:00:00
abstract::Prenatal exposure to organophosphorus pesticides (OPs) has been associated with different neurodevelopmental outcomes across different cohorts. A phenotypic approach may address some of these differences by incorporating information across scales and accounting for the complex correlational structure of neurodevelopme...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2017.07.023
更新日期:2017-10-01 00:00:00
abstract::Nano technological research offered uncountable opportunities for engineered nanoparticles (ENPs) in the field of biomedical, pharmaceutical, agricultural, cosmetics, textiles, automobiles and electronic industry. Large scale commercial production and use of nanoparticles with smaller size and characteristic physico-c...
journal_title:Environmental research
pub_type: 杂志文章,评审
doi:10.1016/j.envres.2019.02.003
更新日期:2019-05-01 00:00:00
abstract::Human cadmium intake derives mainly from food sources, and cadmium can be present in high concentrations in some offal. A meta-analysis using random effects modeling was carried out to integrate the results of 21 controlled randomized trials in which sheep were fed diets with elevated cadmium levels and cadmium concen...
journal_title:Environmental research
pub_type: 杂志文章,meta分析
doi:10.1016/s0013-9351(03)00084-7
更新日期:2004-02-01 00:00:00
abstract::Alien species contribute to global change in all marine ecosystems. Environmental variability can affect species distribution and population sizes, and is therefore expected to influence alien species. In this study, we have investigated temporal variability of 11 alien species representing different trophic levels an...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2011.03.002
更新日期:2011-10-01 00:00:00
abstract::Trifluralin, 2,6-dinitro-N,N-dipropyl-4-trifluoromethylaniline, is a 2,6-dinitro herbicide widely used to control annual grasses and broadleaf weeds in agricultural settings. The association between trifluralin use and common cancer incidence was evaluated among 50,127 private and commercial pesticide applicators in t...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2008.01.010
更新日期:2008-06-01 00:00:00
abstract:INTRODUCTION:Phenols and parabens are ubiquitous environmental contaminants. Evidence from animal studies and limited human data suggest they may be endocrine disruptors. In the current study, we examined associations of phenols and parabens with reproductive and thyroid hormones in 106 pregnant women recruited for the...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2016.07.002
更新日期:2016-11-01 00:00:00
abstract::No nationwide study has ever measured polychlorinated biphenyl (PCB) and organochlorine pesticide (OCP) body burden in Canadians aged 65 years and over. The objective of this study was to determine plasma concentrations of PCB congeners and OCPs in participants from a sub-cohort of the Canadian Study of Health and Agi...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2011.09.017
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVES:This study was to assess the association between different NPs exposure and PON1 genotype on Heart Rate Variability (HRV) parameters among workers. METHODS:This study included 235 non-CVD subjects handled to nanomaterials (NM) and 185 non-exposed controls without CVD from 14 NM plants. All participants comp...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2019.03.015
更新日期:2019-09-01 00:00:00
abstract::The present study aimed to evaluate methylmercury in fish and human hair samples from an important hydroelectrical reservoir, Balbina (Brazil, Amazon). It presents a quite intense fishing activity and there is no known goldmining activity in its watershed. Fish and human hair were analyzed with a new extraction techni...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1006/enrs.1998.3836
更新日期:1998-05-01 00:00:00
abstract::The intake of food cadmium (Cd) in microg/day over time can increase the body burden of this element. Some human populations that consume subsistence rice-based diets low in calcium (Ca), iron (Fe), and zinc (Zn) are more susceptible to Cd poisoning than populations that consume more nutritious diets. This study deter...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1006/enrs.2000.4236
更新日期:2001-03-01 00:00:00
abstract::A semi-industrial approach for simultaneous treatment of eggshell and industrial polyvinyl chloride waste utilizing tools of ball milling is reported therein. On a hundred-gram scale, it is possible to transfer more than 55% of chlorine present in the polyvinyl chloride representing an environmental burden, into harml...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2018.12.005
更新日期:2019-03-01 00:00:00
abstract::Several studies show that most women do not consume enough fish during pregnancy (and afterward) to derive the maximum health benefits for themselves and their babies, according to the USDA guidelines. We engaged in a two-part study to better understand what might be done to encourage women of childbearing age to eat ...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2014.08.027
更新日期:2014-11-01 00:00:00
abstract::Organochlorine compounds (OCCs), such as pesticides and polychlorinated biphenyls (PCBs), are persistent lipophilic chemicals identified as endocrine disruptors, mainly with estrogen-like effects. Northeastern Argentina, near the Paraná River, is characterized by intensive farming and agricultural activities and indus...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2005.12.017
更新日期:2006-09-01 00:00:00
abstract::A major challenge in both the design of epidemiologic studies of exposure to toxic agents and the interpretation of the findings is to recognize and to accommodate the complex biologic assumptions that underlie population-based research. Environmental health research is grounded on a scientific foundation that blends ...
journal_title:Environmental research
pub_type: 杂志文章,评审
doi:10.1016/s0013-9351(05)80229-4
更新日期:1992-10-01 00:00:00
abstract::Heat waves are considered to be increasing in frequency and intensity whereas they comprise a significant weather-related cause of deaths in several countries. Two heat waves occurred in Greece in summer 2007. These severe heat waves are assessed by analyzing the prevailing synoptic conditions, evaluating human therma...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2009.12.002
更新日期:2010-02-01 00:00:00
abstract::Research that analyzes the effect of different environmental factors on the impact of COVID-19 focus primarily on meteorological variables such as humidity and temperature or on air pollution variables. However, noise pollution is also a relevant environmental factor that contributes to the worsening of chronic cardio...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2021.110766
更新日期:2021-01-23 00:00:00
abstract::This study systematically reviewed scientific evidence linking ambient air pollution to physical activity and sedentary behavior in China. A keyword and reference search was conducted in PubMed, Web of Science, and the Cochrane Library. Predetermined selection criteria included-study designs: interventions or experime...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2019.108545
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:Cadmium exposure was found to cause a decline in lung function among the general population, but these findings were limited to smokers and gender differences were not explored. OBJECTIVES:To examine the relationship between cadmium and chronic obstructive pulmonary disease (COPD) according to gender and sm...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2014.04.008
更新日期:2014-07-01 00:00:00