A meta-analysis of literature data relating to the relationships between cadmium intake and toxicity indicators in humans.

Abstract:

:The objective of the study was to determine the relationship between cadmium (Cd) intake and cadmium toxicity indicators by meta-analysis of literature data, in particular beta2-microglobulin (beta2MC), and to compare the results with the current Provisional Tolerable Weekly Intake (PTWI) set by FAO/WHO. The literature survey identified 79 feeding trials involving 27,537 people that were suitable for extraction of cadmium intake, levels in blood and urine and beta2-microglobulin in urine. There was an exponential increase in beta2-microglobulin with increases in cadmium intake above 302 micro g/day, which corresponds to a PTWI of 3.02 micro g/kg of body weight, when a safety margin of 10 is included. This compares with the current level set by FAO/WHO of 7 micro g/kg of body weight. Cadmium in blood and urine were also positively related to cadmium intake and participants' age. There were two principal components of variation in the data set, first: cadmium intake, concentrations of cadmium in blood, urine and beta2-microglobulin in urine, and second: duration and age of exposure.

journal_name

Environ Res

journal_title

Environmental research

authors

Omarova A,Phillips CJ

doi

10.1016/j.envres.2006.09.006

subject

Has Abstract

pub_date

2007-03-01 00:00:00

pages

432-40

issue

3

eissn

0013-9351

issn

1096-0953

pii

S0013-9351(06)00199-X

journal_volume

103

pub_type

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