Hepatic mixed-function oxidase activity in rainbow trout exposed to several polycyclic aromatic compounds.

Abstract:

:The effects of polycyclic aromatic hydrocarbons (PAHs) on microsomal liver enzymes were examined in rainbow trout. Various PAHs (naphthalene through benzo(a)pyrene [B(a)P]) were injected ip to screen for mixed-function oxidase (MFO) activity. Chrysene, B(a)P, and Aroclor 1254 caused MFO induction. When fish were also exposed to solubilized pyrene, fluoranthene, and B(a)P in water, bioaccumulation of B(a)P resulted in MFO induction, whereas bioaccumulation of pyrene and fluoranthene did not. Based on water and injection exposure to B(a)P, it was predicted that tissue concentrations in excess of 300 micrograms/kg B(a)P would be accompanied by MFO induction in rainbow trout.

journal_name

Environ Res

journal_title

Environmental research

authors

Gerhart EH,Carlson RM

doi

10.1016/0013-9351(78)90031-2

subject

Has Abstract

pub_date

1978-10-01 00:00:00

pages

284-95

issue

2

eissn

0013-9351

issn

1096-0953

pii

0013-9351(78)90031-2

journal_volume

17

pub_type

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