Abstract：
OBJECTIVES:This study was to assess the association between different NPs exposure and PON1 genotype on Heart Rate Variability (HRV) parameters among workers. METHODS:This study included 235 non-CVD subjects handled to nanomaterials (NM) and 185 non-exposed controls without CVD from 14 NM plants. All participants completed short-term HRV measurements, and were collected blood specimens to measure PON1 activities and the genotype of the PON1 Q192R polymorphism. RESULTS:In a multivariate regression model, this study observed a positive relationship between nano-Ag exposure and HRV time-domain (RMSSD) and frequency-domain (HF). After adjusting for confounders, the results showed positive associations between RR homozygosity, PON1 paraoxonase/arylesterase activities with HRV, and was particularly noteworthy in RMSSD and HF. CONCLUSIONS:This study shows a significant increment of RMSSD and HF among workers who handled Nano-Ag materials. These results imply that Nano-Ag and PON1 Q192R genotype can trigger ANS reflexes and alter cardiac frequency and function.
journal_name
Environ Resjournal_title
Environmental researchauthors
Wu WT,Wang CC,Liou SHdoi
10.1016/j.envres.2019.03.015subject
Has Abstractpub_date
2019-09-01 00:00:00pages
108377eissn
0013-9351issn
1096-0953pii
S0013-9351(19)30143-4journal_volume
176pub_type
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