Abstract:
BACKGROUND:Exposure to traffic pollution has been linked to numerous adverse health endpoints. Despite this, limited data examining traffic exposures during realistic commutes and acute response exists. OBJECTIVES:We conducted the Atlanta Commuters Exposures (ACE-1) Study, an extensive panel-based exposure and health study, to measure chemically-resolved in-vehicle exposures and corresponding changes in acute oxidative stress, lipid peroxidation, pulmonary and systemic inflammation and autonomic response. METHODS:We recruited 42 adults (21 with and 21 without asthma) to conduct two 2-h scripted highway commutes during morning rush hour in the metropolitan Atlanta area. A suite of in-vehicle particulate components were measured in the subjects' private vehicles. Biomarker measurements were conducted before, during, and immediately after the commutes and in 3 hourly intervals after commutes. RESULTS:At measurement time points within 3h after the commute, we observed mild to pronounced elevations relative to baseline in exhaled nitric oxide, C-reactive-protein, and exhaled malondialdehyde, indicative of pulmonary and systemic inflammation and oxidative stress initiation, as well as decreases relative to baseline levels in the time-domain heart-rate variability parameters, SDNN and rMSSD, indicative of autonomic dysfunction. We did not observe any detectable changes in lung function measurements (FEV1, FVC), the frequency-domain heart-rate variability parameter or other systemic biomarkers of vascular injury. Water soluble organic carbon was associated with changes in eNO at all post-commute time-points (p<0.0001). CONCLUSIONS:Our results point to measureable changes in pulmonary and autonomic biomarkers following a scripted 2-h highway commute.
journal_name
Environ Resjournal_title
Environmental researchauthors
Sarnat JA,Golan R,Greenwald R,Raysoni AU,Kewada P,Winquist A,Sarnat SE,Dana Flanders W,Mirabelli MC,Zora JE,Bergin MH,Yip Fdoi
10.1016/j.envres.2014.05.004subject
Has Abstractpub_date
2014-08-01 00:00:00pages
66-76eissn
0013-9351issn
1096-0953pii
S0013-9351(14)00156-Xjournal_volume
133pub_type
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